TGFBR3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	35% ± 16%	Explore
fibroblast	32 studies	34% ± 15%	Explore
natural killer cell	26 studies	29% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	33% ± 9%	Explore
endothelial cell of lymphatic vessel	14 studies	31% ± 14%	Explore
smooth muscle cell	12 studies	31% ± 11%	Explore
capillary endothelial cell	11 studies	26% ± 11%	Explore
vein endothelial cell	11 studies	33% ± 20%	Explore
adipocyte	11 studies	64% ± 20%	Explore
myofibroblast cell	10 studies	42% ± 11%	Explore
pericyte	10 studies	23% ± 7%	Explore
astrocyte	10 studies	37% ± 18%	Explore
endothelial cell of vascular tree	9 studies	27% ± 10%	Explore
CD8-positive, alpha-beta T cell	8 studies	27% ± 8%	Explore
mature NK T cell	8 studies	23% ± 4%	Explore
mucosal invariant T cell	7 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	26% ± 8%	Explore
connective tissue cell	6 studies	28% ± 13%	Explore
gamma-delta T cell	6 studies	27% ± 7%	Explore
podocyte	5 studies	72% ± 19%	Explore
adventitial cell	5 studies	36% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	23% ± 6%	Explore
endothelial cell of sinusoid	4 studies	40% ± 10%	Explore
cardiac muscle cell	4 studies	25% ± 3%	Explore
T cell	4 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	27% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
hepatic stellate cell	3 studies	34% ± 11%	Explore
glomerular endothelial cell	3 studies	39% ± 2%	Explore
CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
endocardial cell	3 studies	30% ± 10%	Explore
lymphocyte	3 studies	29% ± 4%	Explore
GABAergic neuron	3 studies	34% ± 6%	Explore
mural cell	3 studies	30% ± 10%	Explore
myoepithelial cell	3 studies	37% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
adipose	5 studies	40% ± 29%	Explore
heart	4 studies	26% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	20827.67	180 / 180	93%	10.87	398 / 430
kidney	98%	4259.93	87 / 89	93%	15.33	836 / 901
skin	100%	7259.46	1804 / 1809	90%	14.24	427 / 472
prostate	94%	4953.31	231 / 245	96%	13.38	480 / 502
adrenal gland	100%	9089.90	258 / 258	87%	20.25	201 / 230
breast	100%	16784.91	459 / 459	86%	23.18	965 / 1118
thymus	98%	4773.66	639 / 653	87%	9.34	527 / 605
bladder	100%	15875.67	21 / 21	81%	12.65	410 / 504
esophagus	94%	10003.27	1358 / 1445	83%	11.73	151 / 183
intestine	96%	7787.40	924 / 966	80%	8.79	424 / 527
lung	99%	9251.08	574 / 578	74%	8.66	854 / 1155
uterus	100%	11917.17	170 / 170	64%	10.23	292 / 459
pancreas	65%	2017.43	214 / 328	94%	14.51	167 / 178
stomach	71%	5036.93	256 / 359	80%	10.74	229 / 286
liver	48%	1363.65	109 / 226	74%	7.72	300 / 406
brain	10%	195.86	251 / 2642	91%	10.37	641 / 705
adipose	100%	17028.67	1204 / 1204	0%	0	0 / 0
spleen	100%	8240.61	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.32	1 / 1
blood vessel	96%	5605.56	1282 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	83%	6.54	66 / 80
heart	77%	2779.62	664 / 861	0%	0	0 / 0
muscle	64%	2098.24	516 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	45%	2.85	13 / 29
tonsil	0%	0	0 / 0	40%	2.66	18 / 45
peripheral blood	12%	366.83	115 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030511	Biological process	positive regulation of transforming growth factor beta receptor signaling pathway
GO_0017015	Biological process	regulation of transforming growth factor beta receptor signaling pathway
GO_0061384	Biological process	heart trabecula morphogenesis
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_0046328	Biological process	regulation of JNK cascade
GO_0003151	Biological process	outflow tract morphogenesis
GO_0060979	Biological process	vasculogenesis involved in coronary vascular morphogenesis
GO_0060392	Biological process	negative regulation of SMAD protein signal transduction
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0060045	Biological process	positive regulation of cardiac muscle cell proliferation
GO_0060347	Biological process	heart trabecula formation
GO_0010628	Biological process	positive regulation of gene expression
GO_0062009	Biological process	secondary palate development
GO_0060939	Biological process	epicardium-derived cardiac fibroblast cell development
GO_1901202	Biological process	negative regulation of extracellular matrix assembly
GO_0001889	Biological process	liver development
GO_0031100	Biological process	animal organ regeneration
GO_0060391	Biological process	positive regulation of SMAD protein signal transduction
GO_0003223	Biological process	ventricular compact myocardium morphogenesis
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0055010	Biological process	ventricular cardiac muscle tissue morphogenesis
GO_0060317	Biological process	cardiac epithelial to mesenchymal transition
GO_0003007	Biological process	heart morphogenesis
GO_0090050	Biological process	positive regulation of cell migration involved in sprouting angiogenesis
GO_0030509	Biological process	BMP signaling pathway
GO_0006955	Biological process	immune response
GO_0060038	Biological process	cardiac muscle cell proliferation
GO_0003150	Biological process	muscular septum morphogenesis
GO_0032354	Biological process	response to follicle-stimulating hormone
GO_0060216	Biological process	definitive hemopoiesis
GO_0035556	Biological process	intracellular signal transduction
GO_0001666	Biological process	response to hypoxia
GO_0007181	Biological process	transforming growth factor beta receptor complex assembly
GO_0060412	Biological process	ventricular septum morphogenesis
GO_0034695	Biological process	response to prostaglandin E
GO_0030336	Biological process	negative regulation of cell migration
GO_0060318	Biological process	definitive erythrocyte differentiation
GO_0034699	Biological process	response to luteinizing hormone
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0016477	Biological process	cell migration
GO_0043124	Biological process	negative regulation of canonical NF-kappaB signal transduction
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0034673	Cellular component	inhibin-betaglycan-ActRII complex
GO_0070062	Cellular component	extracellular exosome
GO_0009986	Cellular component	cell surface
GO_0070123	Molecular function	transforming growth factor beta receptor activity, type III
GO_0008201	Molecular function	heparin binding
GO_0015026	Molecular function	coreceptor activity
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0046332	Molecular function	SMAD binding
GO_0048185	Molecular function	activin binding
GO_0050431	Molecular function	transforming growth factor beta binding
GO_0030165	Molecular function	PDZ domain binding
GO_0036122	Molecular function	BMP binding
GO_0005539	Molecular function	glycosaminoglycan binding
GO_0005024	Molecular function	transforming growth factor beta receptor activity
GO_0005114	Molecular function	type II transforming growth factor beta receptor binding
GO_0005160	Molecular function	transforming growth factor beta receptor binding
GO_0017134	Molecular function	fibroblast growth factor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TGFBR3
Protein name	Transforming growth factor beta receptor 3 Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) Transforming growth factor, beta receptor III
Synonyms	hCG_21711
Description	FUNCTION: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility . .
Accessions	ENST00000465892.6 [Q03167-2] ENST00000533089.5 ENST00000212355.9 [Q03167-1] ENST00000370399.6 [Q03167-2] E9PAW7 ENST00000532540.5 ENST00000417833.2 E9PMG7 A0A0A8KWK3 ENST00000525962.5 [Q03167-1] E9PKY4 Q03167

TGFBR3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review