Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 7543.87 | 1445 / 1445 | 100% | 42.41 | 183 / 183 |
| prostate | 100% | 7556.67 | 245 / 245 | 100% | 25.13 | 502 / 502 |
| ovary | 100% | 11225.62 | 180 / 180 | 100% | 30.65 | 429 / 430 |
| intestine | 100% | 8282.14 | 966 / 966 | 100% | 23.71 | 525 / 527 |
| thymus | 100% | 9463.43 | 653 / 653 | 100% | 27.21 | 602 / 605 |
| breast | 100% | 8918.88 | 459 / 459 | 99% | 34.66 | 1112 / 1118 |
| skin | 100% | 9080.06 | 1809 / 1809 | 99% | 26.65 | 469 / 472 |
| uterus | 100% | 11921.33 | 170 / 170 | 99% | 24.20 | 456 / 459 |
| stomach | 100% | 5736.54 | 359 / 359 | 99% | 28.70 | 284 / 286 |
| lung | 100% | 7062.67 | 578 / 578 | 99% | 27.19 | 1146 / 1155 |
| pancreas | 100% | 4015.72 | 328 / 328 | 99% | 19.81 | 176 / 178 |
| kidney | 100% | 4397.67 | 89 / 89 | 98% | 21.56 | 886 / 901 |
| bladder | 100% | 8058.43 | 21 / 21 | 98% | 18.38 | 493 / 504 |
| brain | 98% | 4811.86 | 2592 / 2642 | 99% | 32.03 | 701 / 705 |
| adrenal gland | 100% | 4689.83 | 258 / 258 | 94% | 14.22 | 217 / 230 |
| liver | 100% | 3294.64 | 226 / 226 | 87% | 11.57 | 352 / 406 |
| adipose | 100% | 8091.53 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 9047.45 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 26.00 | 80 / 80 |
| muscle | 100% | 7519.28 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 8424.26 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.59 | 1 / 1 |
| heart | 99% | 4027.17 | 850 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 26.94 | 44 / 45 |
| peripheral blood | 98% | 6057.98 | 907 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 18.75 | 28 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008589 | Biological process | regulation of smoothened signaling pathway |
| GO_0030511 | Biological process | positive regulation of transforming growth factor beta receptor signaling pathway |
| GO_0016479 | Biological process | negative regulation of transcription by RNA polymerase I |
| GO_0034644 | Biological process | cellular response to UV |
| GO_0007249 | Biological process | canonical NF-kappaB signal transduction |
| GO_0007165 | Biological process | signal transduction |
| GO_0042733 | Biological process | embryonic digit morphogenesis |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0031648 | Biological process | protein destabilization |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_1900034 | Biological process | regulation of cellular response to heat |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0002223 | Biological process | stimulatory C-type lectin receptor signaling pathway |
| GO_0031669 | Biological process | cellular response to nutrient levels |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
| GO_1905168 | Biological process | positive regulation of double-strand break repair via homologous recombination |
| GO_0042592 | Biological process | homeostatic process |
| GO_0018076 | Biological process | N-terminal peptidyl-lysine acetylation |
| GO_0006473 | Biological process | protein acetylation |
| GO_0048511 | Biological process | rhythmic process |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0000123 | Cellular component | histone acetyltransferase complex |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0044017 | Molecular function | histone H3K27 acetyltransferase activity |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0061733 | Molecular function | peptide-lysine-N-acetyltransferase activity |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0120300 | Molecular function | peptide lactyltransferase (CoA-dependent) activity |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0016407 | Molecular function | acetyltransferase activity |
| GO_0001223 | Molecular function | transcription coactivator binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0002039 | Molecular function | p53 binding |
| GO_0034212 | Molecular function | peptide N-acetyltransferase activity |
| GO_0031490 | Molecular function | chromatin DNA binding |
| GO_0004402 | Molecular function | histone acetyltransferase activity |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0043426 | Molecular function | MRF binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0043993 | Molecular function | histone H3K18 acetyltransferase activity |
| GO_0003684 | Molecular function | damaged DNA binding |
| Gene name | CREBBP |
| Protein name | CREB binding protein histone acetyltransferase (EC 2.3.1.48) CREBBP protein CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) CREBBP |
| Synonyms | CBP |
| Description | FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation . Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) . Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 . Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers . Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) . Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region . Acetylates DDX21, thereby inhibiting DDX21 helicase activity . Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) . Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway . . |
| Accessions | B5A221 B5A232 B5A223 B5A244 B5A218 I3L3I5 B5A250 Q4G0V0 B5A227 B5A235 I3L0Q1 B5A215 ENST00000637492.1 B5A242 ENST00000382070.7 [Q92793-2] A0A1B0GUU0 B5A216 B5A211 B5A229 B5A241 B5A253 B5A219 B5A226 B5A228 B5A224 B5A214 ENST00000573517.6 B5A213 ENST00000262367.10 [Q92793-1] I3L466 ENST00000572134.1 B5A234 ENST00000571826.5 B5A231 B5A222 B5A236 B5A239 B5A220 B5A243 B5A210 B5A238 ENST00000570939.2 B5A217 Q92793 B5A230 B5A233 B5A246 B5A225 B5A249 B5A212 I3L293 B5A252 B5A237 B5A248 B5A240 |
