HSP90B1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	47 studies	53% ± 20%	Explore
endothelial cell	45 studies	56% ± 21%	Explore
B cell	43 studies	41% ± 17%	Explore
fibroblast	42 studies	60% ± 22%	Explore
natural killer cell	39 studies	51% ± 16%	Explore
pericyte	35 studies	53% ± 24%	Explore
CD8-positive, alpha-beta T cell	33 studies	47% ± 17%	Explore
T cell	32 studies	41% ± 16%	Explore
plasma cell	30 studies	81% ± 18%	Explore
smooth muscle cell	30 studies	49% ± 20%	Explore
plasmacytoid dendritic cell	30 studies	85% ± 14%	Explore
CD4-positive, alpha-beta T cell	30 studies	44% ± 15%	Explore
conventional dendritic cell	29 studies	62% ± 14%	Explore
classical monocyte	27 studies	47% ± 17%	Explore
dendritic cell	25 studies	54% ± 22%	Explore
non-classical monocyte	25 studies	47% ± 15%	Explore
regulatory T cell	25 studies	43% ± 15%	Explore
mast cell	24 studies	51% ± 21%	Explore
epithelial cell	24 studies	59% ± 24%	Explore
monocyte	21 studies	48% ± 17%	Explore
endothelial cell of lymphatic vessel	21 studies	61% ± 20%	Explore
basal cell	21 studies	62% ± 17%	Explore
connective tissue cell	21 studies	65% ± 19%	Explore
gamma-delta T cell	20 studies	53% ± 16%	Explore
mature NK T cell	20 studies	47% ± 14%	Explore
memory B cell	20 studies	45% ± 15%	Explore
naive B cell	19 studies	39% ± 13%	Explore
ciliated cell	18 studies	63% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	41% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	53% ± 15%	Explore
mucosal invariant T cell	15 studies	54% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	46% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	59% ± 13%	Explore
myeloid cell	15 studies	55% ± 22%	Explore
endothelial cell of artery	14 studies	54% ± 17%	Explore
myofibroblast cell	14 studies	62% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	50% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	53% ± 14%	Explore
capillary endothelial cell	13 studies	49% ± 18%	Explore
vein endothelial cell	13 studies	57% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	52% ± 17%	Explore
plasmablast	12 studies	89% ± 12%	Explore
secretory cell	12 studies	70% ± 12%	Explore
astrocyte	12 studies	31% ± 11%	Explore
mesothelial cell	12 studies	69% ± 25%	Explore
microglial cell	12 studies	34% ± 17%	Explore
endothelial cell of vascular tree	12 studies	57% ± 14%	Explore
goblet cell	11 studies	53% ± 18%	Explore
oligodendrocyte	10 studies	29% ± 12%	Explore
progenitor cell	10 studies	70% ± 22%	Explore
abnormal cell	10 studies	62% ± 24%	Explore
neuron	10 studies	42% ± 20%	Explore
IgG plasma cell	10 studies	80% ± 18%	Explore
type I pneumocyte	9 studies	42% ± 23%	Explore
type II pneumocyte	9 studies	50% ± 21%	Explore
club cell	9 studies	51% ± 23%	Explore
leukocyte	9 studies	52% ± 16%	Explore
oligodendrocyte precursor cell	9 studies	31% ± 16%	Explore
IgA plasma cell	9 studies	86% ± 13%	Explore
innate lymphoid cell	8 studies	47% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	61% ± 19%	Explore
alveolar macrophage	7 studies	58% ± 20%	Explore
GABAergic neuron	7 studies	32% ± 16%	Explore
epithelial cell of proximal tubule	7 studies	49% ± 21%	Explore
transit amplifying cell	7 studies	45% ± 25%	Explore
hematopoietic stem cell	7 studies	60% ± 15%	Explore
T follicular helper cell	7 studies	38% ± 15%	Explore
erythrocyte	7 studies	45% ± 14%	Explore
hematopoietic precursor cell	6 studies	67% ± 17%	Explore
ionocyte	6 studies	65% ± 11%	Explore
respiratory goblet cell	6 studies	57% ± 18%	Explore
platelet	6 studies	24% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	56% ± 13%	Explore
mononuclear phagocyte	6 studies	56% ± 22%	Explore
kidney loop of Henle epithelial cell	6 studies	53% ± 24%	Explore
renal alpha-intercalated cell	6 studies	69% ± 13%	Explore
enterocyte	6 studies	53% ± 18%	Explore
glutamatergic neuron	6 studies	39% ± 18%	Explore
glial cell	6 studies	41% ± 25%	Explore
lymphocyte	6 studies	42% ± 25%	Explore
precursor B cell	6 studies	60% ± 15%	Explore
immature B cell	6 studies	46% ± 13%	Explore
adipocyte	6 studies	33% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	56% ± 10%	Explore
hepatocyte	6 studies	49% ± 26%	Explore
CD4-positive helper T cell	5 studies	38% ± 19%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	53% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	50% ± 14%	Explore
exhausted T cell	5 studies	52% ± 11%	Explore
endothelial cell of sinusoid	5 studies	40% ± 23%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	77% ± 7%	Explore
enteroendocrine cell	5 studies	61% ± 25%	Explore
erythroblast	5 studies	51% ± 25%	Explore
brush cell	5 studies	44% ± 21%	Explore
neuroendocrine cell	5 studies	69% ± 21%	Explore
group 3 innate lymphoid cell	5 studies	64% ± 12%	Explore
mucus secreting cell	5 studies	48% ± 18%	Explore
granulocyte	5 studies	48% ± 14%	Explore
interneuron	5 studies	37% ± 20%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	52% ± 18%	Explore
deuterosomal cell	4 studies	53% ± 6%	Explore
duct epithelial cell	4 studies	57% ± 22%	Explore
pancreatic A cell	4 studies	78% ± 11%	Explore
type B pancreatic cell	4 studies	82% ± 16%	Explore
monocyte-derived dendritic cell	4 studies	58% ± 16%	Explore
glomerular endothelial cell	4 studies	54% ± 10%	Explore
intestinal crypt stem cell	4 studies	52% ± 17%	Explore
retinal rod cell	4 studies	30% ± 11%	Explore
pro-B cell	4 studies	52% ± 11%	Explore
amacrine cell	4 studies	41% ± 13%	Explore
retina horizontal cell	4 studies	37% ± 14%	Explore
retinal pigment epithelial cell	4 studies	45% ± 22%	Explore
adventitial cell	4 studies	71% ± 11%	Explore
inflammatory macrophage	4 studies	43% ± 16%	Explore
acinar cell	4 studies	60% ± 23%	Explore
muscle cell	4 studies	34% ± 12%	Explore
neutrophil	4 studies	25% ± 11%	Explore
intermediate monocyte	4 studies	59% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	68% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	56% ± 15%	Explore
IgM plasma cell	4 studies	73% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	63% ± 30%	Explore
T-helper 17 cell	4 studies	48% ± 24%	Explore
double negative thymocyte	4 studies	60% ± 17%	Explore
precursor cell	3 studies	82% ± 7%	Explore
squamous epithelial cell	3 studies	48% ± 22%	Explore
pancreatic D cell	3 studies	81% ± 14%	Explore
podocyte	3 studies	84% ± 7%	Explore
kidney connecting tubule epithelial cell	3 studies	76% ± 6%	Explore
neural crest cell	3 studies	71% ± 2%	Explore
retinal ganglion cell	3 studies	46% ± 18%	Explore
renal principal cell	3 studies	73% ± 4%	Explore
extravillous trophoblast	3 studies	98% ± 2%	Explore
placental villous trophoblast	3 studies	95% ± 3%	Explore
common myeloid progenitor	3 studies	59% ± 14%	Explore
megakaryocyte	3 studies	37% ± 5%	Explore
Schwann cell	3 studies	53% ± 30%	Explore
retinal cone cell	3 studies	55% ± 7%	Explore
serous secreting cell	3 studies	55% ± 1%	Explore
tissue-resident macrophage	3 studies	61% ± 23%	Explore
intraepithelial lymphocyte	3 studies	37% ± 16%	Explore
Mueller cell	3 studies	36% ± 3%	Explore
rod bipolar cell	3 studies	26% ± 6%	Explore
chondrocyte	3 studies	40% ± 21%	Explore
germinal center B cell	3 studies	19% ± 5%	Explore
myoepithelial cell	3 studies	70% ± 16%	Explore
pancreatic ductal cell	3 studies	82% ± 10%	Explore
neural progenitor cell	3 studies	24% ± 4%	Explore
granulocyte monocyte progenitor cell	3 studies	81% ± 6%	Explore
keratinocyte	3 studies	36% ± 5%	Explore
T-helper 1 cell	3 studies	63% ± 15%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	57% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	58% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	50% ± 12%	Explore
lung	18 studies	54% ± 16%	Explore
brain	14 studies	34% ± 15%	Explore
intestine	12 studies	54% ± 22%	Explore
kidney	9 studies	54% ± 14%	Explore
eye	9 studies	32% ± 15%	Explore
liver	8 studies	45% ± 16%	Explore
bone marrow	6 studies	52% ± 22%	Explore
uterus	6 studies	60% ± 24%	Explore
pancreas	5 studies	66% ± 24%	Explore
prostate	5 studies	52% ± 21%	Explore
lymph node	5 studies	51% ± 19%	Explore
placenta	4 studies	74% ± 31%	Explore
heart	4 studies	29% ± 11%	Explore
adipose	4 studies	36% ± 11%	Explore
breast	4 studies	57% ± 5%	Explore
ovary	3 studies	48% ± 17%	Explore
adrenal gland	3 studies	43% ± 7%	Explore
esophagus	3 studies	44% ± 25%	Explore
skin	3 studies	41% ± 5%	Explore
thymus	3 studies	57% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	36797.91	180 / 180	100%	427.33	430 / 430
pancreas	100%	31597.62	328 / 328	100%	469.73	178 / 178
thymus	100%	100879.18	653 / 653	100%	1011.14	604 / 605
lung	100%	40285.62	577 / 578	100%	619.00	1155 / 1155
uterus	100%	31547.04	170 / 170	100%	675.94	458 / 459
liver	100%	48677.01	226 / 226	100%	611.93	405 / 406
breast	100%	32189.08	459 / 459	100%	586.86	1115 / 1118
bladder	100%	31924.90	21 / 21	99%	548.93	500 / 504
prostate	100%	29408.66	244 / 245	100%	869.91	500 / 502
kidney	100%	35645.21	89 / 89	99%	509.90	890 / 901
esophagus	100%	19744.78	1442 / 1445	99%	493.98	181 / 183
stomach	100%	25107.61	359 / 359	99%	504.36	282 / 286
intestine	100%	30312.67	966 / 966	98%	569.79	516 / 527
adrenal gland	100%	45403.14	258 / 258	98%	444.50	225 / 230
skin	99%	39370.13	1799 / 1809	98%	589.84	461 / 472
brain	94%	16391.41	2496 / 2642	100%	310.17	702 / 705
adipose	100%	36793.96	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	454.80	29 / 29
spleen	100%	47253.40	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	496.35	45 / 45
ureter	0%	0	0 / 0	100%	268.47	1 / 1
blood vessel	100%	45445.42	1333 / 1335	0%	0	0 / 0
heart	94%	25975.90	810 / 861	0%	0	0 / 0
peripheral blood	66%	21505.50	610 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	63%	137.11	50 / 80
muscle	50%	4831.60	400 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051208	Biological process	sequestering of calcium ion
GO_0030970	Biological process	retrograde protein transport, ER to cytosol
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0043666	Biological process	regulation of phosphoprotein phosphatase activity
GO_0071287	Biological process	cellular response to manganese ion
GO_0071318	Biological process	cellular response to ATP
GO_0006457	Biological process	protein folding
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0001666	Biological process	response to hypoxia
GO_0034975	Biological process	protein folding in endoplasmic reticulum
GO_0031247	Biological process	actin rod assembly
GO_0015031	Biological process	protein transport
GO_0036503	Biological process	ERAD pathway
GO_0030496	Cellular component	midbody
GO_0097524	Cellular component	sperm plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005790	Cellular component	smooth endoplasmic reticulum
GO_0071682	Cellular component	endocytic vesicle lumen
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0033018	Cellular component	sarcoplasmic reticulum lumen
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005925	Cellular component	focal adhesion
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0034663	Cellular component	endoplasmic reticulum chaperone complex
GO_0042470	Cellular component	melanosome
GO_0005634	Cellular component	nucleus
GO_0019903	Molecular function	protein phosphatase binding
GO_0051082	Molecular function	unfolded protein binding
GO_0050750	Molecular function	low-density lipoprotein particle receptor binding
GO_0140662	Molecular function	ATP-dependent protein folding chaperone
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	HSP90B1
Protein name	Endoplasmin (94 kDa glucose-regulated protein) (Heat shock protein 90 kDa beta member 1) Heat shock protein 90 beta family member 1 Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)
Synonyms	hCG_21864 HEL35 GRP94 HEL-S-125m TRA1
Description	FUNCTION: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) . Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 . .
Accessions	A0A7P0T8C8 ENST00000680663.1 A0A7P0T823 ENST00000680899.1 ENST00000681172.1 ENST00000681174.1 A0A7P0TAE1 ENST00000681861.1 ENST00000681941.1 V9HWP2 ENST00000681949.1 ENST00000680391.1 P14625 A0A7P0TAC2 ENST00000679861.1 A0A7P0TAG4 ENST00000681698.1 ENST00000679538.1 ENST00000614327.2 A0A7P0T8R3 ENST00000299767.10 A0A087WT78 A0A7P0Z405 A0A7P0T917 A0A7P0TAY2 ENST00000680316.1 ENST00000680762.1 Q96GW1 ENST00000549334.5 A0A7P0Z4B4 ENST00000550595.2 F8W026 A0A7P0T885 A0A7P0TAT8 H0YIV0 ENST00000680370.1 A0A7P0TBC2

HSP90B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review