DDIT4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032984Biological processprotein-containing complex disassembly
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0048011Biological processneurotrophin TRK receptor signaling pathway
GO_0051607Biological processdefense response to virus
GO_0032007Biological processnegative regulation of TOR signaling
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0001764Biological processneuron migration
GO_0072593Biological processreactive oxygen species metabolic process
GO_0045820Biological processnegative regulation of glycolytic process
GO_0030182Biological processneuron differentiation
GO_0035556Biological processintracellular signal transduction
GO_0001666Biological processresponse to hypoxia
GO_0007420Biological processbrain development
GO_0006915Biological processapoptotic process
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0071889Molecular function14-3-3 protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDDIT4
Protein nameDNA damage-inducible transcript 4 protein (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)
DNA damage-inducible transcript 4 protein
SynonymsREDD1
RTP801
DescriptionFUNCTION: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. .

AccessionsA0A7P0Z4M7
Q9NX09
ENST00000681898.1
ENST00000491934.3
ENST00000307365.4