ITPR2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
macrophage	35 studies	43% ± 22%	Explore
endothelial cell	27 studies	35% ± 16%	Explore
astrocyte	19 studies	65% ± 21%	Explore
microglial cell	18 studies	73% ± 20%	Explore
oligodendrocyte precursor cell	15 studies	63% ± 19%	Explore
fibroblast	12 studies	33% ± 13%	Explore
monocyte	11 studies	35% ± 16%	Explore
plasmacytoid dendritic cell	11 studies	26% ± 7%	Explore
myeloid cell	11 studies	43% ± 20%	Explore
adipocyte	10 studies	63% ± 16%	Explore
B cell	9 studies	32% ± 15%	Explore
pericyte	9 studies	35% ± 12%	Explore
endothelial cell of artery	9 studies	34% ± 16%	Explore
mast cell	9 studies	34% ± 11%	Explore
dendritic cell	8 studies	32% ± 12%	Explore
GABAergic neuron	7 studies	41% ± 14%	Explore
T cell	7 studies	29% ± 8%	Explore
glutamatergic neuron	7 studies	43% ± 19%	Explore
mesothelial cell	7 studies	37% ± 13%	Explore
oligodendrocyte	7 studies	29% ± 15%	Explore
smooth muscle cell	7 studies	33% ± 10%	Explore
hepatocyte	6 studies	56% ± 31%	Explore
classical monocyte	6 studies	24% ± 8%	Explore
retinal cone cell	6 studies	45% ± 22%	Explore
type II pneumocyte	6 studies	41% ± 11%	Explore
leukocyte	6 studies	51% ± 24%	Explore
natural killer cell	5 studies	29% ± 9%	Explore
ionocyte	5 studies	53% ± 12%	Explore
mononuclear phagocyte	5 studies	33% ± 10%	Explore
conventional dendritic cell	5 studies	21% ± 6%	Explore
non-classical monocyte	5 studies	24% ± 7%	Explore
epithelial cell	5 studies	33% ± 18%	Explore
interneuron	5 studies	36% ± 18%	Explore
cardiac muscle cell	5 studies	29% ± 6%	Explore
vein endothelial cell	5 studies	38% ± 18%	Explore
type I pneumocyte	5 studies	27% ± 3%	Explore
renal alpha-intercalated cell	4 studies	62% ± 32%	Explore
plasma cell	4 studies	42% ± 10%	Explore
CD4-positive, alpha-beta T cell	4 studies	25% ± 4%	Explore
CD8-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
lymphocyte	4 studies	35% ± 19%	Explore
brush cell	4 studies	61% ± 15%	Explore
alveolar macrophage	4 studies	49% ± 21%	Explore
club cell	4 studies	40% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	22% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	22% ± 5%	Explore
hematopoietic precursor cell	3 studies	31% ± 17%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	73% ± 16%	Explore
neuron	3 studies	52% ± 34%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	25% ± 6%	Explore
capillary endothelial cell	3 studies	19% ± 4%	Explore
endocardial cell	3 studies	49% ± 20%	Explore
tissue-resident macrophage	3 studies	46% ± 20%	Explore
ciliated cell	3 studies	22% ± 6%	Explore
retinal rod cell	3 studies	45% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	20% ± 4%	Explore
endothelial cell of vascular tree	3 studies	48% ± 14%	Explore
retinal pigment epithelial cell	3 studies	30% ± 17%	Explore
connective tissue cell	3 studies	27% ± 6%	Explore
ependymal cell	3 studies	46% ± 17%	Explore
endothelial cell of lymphatic vessel	3 studies	25% ± 4%	Explore
basal cell	3 studies	49% ± 25%	Explore
goblet cell	3 studies	43% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	52% ± 23%	Explore
kidney loop of Henle epithelial cell	3 studies	52% ± 24%	Explore
renal principal cell	3 studies	43% ± 16%	Explore
regulatory T cell	3 studies	23% ± 6%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
brain	18 studies	33% ± 12%	Explore
lung	6 studies	30% ± 10%	Explore
heart	5 studies	30% ± 8%	Explore
liver	4 studies	42% ± 28%	Explore
eye	4 studies	37% ± 14%	Explore
kidney	4 studies	44% ± 19%	Explore
peripheral blood	3 studies	17% ± 1%	Explore
adipose	3 studies	36% ± 10%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	3133.11	459 / 459	96%	30.14	1071 / 1118
brain	96%	1758.01	2542 / 2642	99%	23.74	696 / 705
thymus	100%	1637.18	652 / 653	95%	14.13	574 / 605
liver	100%	3793.00	226 / 226	93%	21.71	379 / 406
prostate	100%	1620.89	244 / 245	93%	16.99	466 / 502
adrenal gland	100%	5853.33	258 / 258	87%	13.52	200 / 230
esophagus	100%	2445.11	1445 / 1445	85%	11.14	156 / 183
pancreas	99%	1623.32	325 / 328	84%	9.04	149 / 178
kidney	100%	2121.47	89 / 89	82%	13.02	738 / 901
skin	100%	3736.75	1809 / 1809	79%	12.46	374 / 472
lung	99%	2086.37	575 / 578	79%	9.11	911 / 1155
stomach	100%	1429.87	358 / 359	77%	9.65	220 / 286
intestine	100%	2796.39	966 / 966	76%	9.98	399 / 527
ovary	100%	2219.82	180 / 180	66%	8.49	283 / 430
bladder	100%	1419.62	21 / 21	59%	6.22	298 / 504
uterus	100%	1885.62	170 / 170	57%	5.23	260 / 459
adipose	100%	2410.26	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	17.65	29 / 29
spleen	100%	1931.32	241 / 241	0%	0	0 / 0
blood vessel	100%	1766.22	1330 / 1335	0%	0	0 / 0
heart	93%	1175.11	798 / 861	0%	0	0 / 0
peripheral blood	84%	2752.67	780 / 929	0%	0	0 / 0
muscle	71%	487.87	572 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	67%	6.36	30 / 45
eye	0%	0	0 / 0	48%	6.62	38 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1