IL1A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL1A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL1A at tissue level.

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0051781Biological processpositive regulation of cell division
GO_0007283Biological processspermatogenesis
GO_0006954Biological processinflammatory response
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0034605Biological processcellular response to heat
GO_0007507Biological processheart development
GO_0045766Biological processpositive regulation of angiogenesis
GO_0002248Biological processconnective tissue replacement involved in inflammatory response wound healing
GO_0010332Biological processresponse to gamma radiation
GO_0046330Biological processpositive regulation of JNK cascade
GO_0010628Biological processpositive regulation of gene expression
GO_0010193Biological processresponse to ozone
GO_0050999Biological processregulation of nitric-oxide synthase activity
GO_0031424Biological processkeratinization
GO_1904445Biological processnegative regulation of establishment of Sertoli cell barrier
GO_0006883Biological processintracellular sodium ion homeostasis
GO_0010893Biological processpositive regulation of steroid biosynthetic process
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0006955Biological processimmune response
GO_0050714Biological processpositive regulation of protein secretion
GO_0033092Biological processpositive regulation of immature T cell proliferation in thymus
GO_0045840Biological processpositive regulation of mitotic nuclear division
GO_1902624Biological processpositive regulation of neutrophil migration
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0001666Biological processresponse to hypoxia
GO_0033591Biological processresponse to L-ascorbic acid
GO_0010243Biological processresponse to organonitrogen compound
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0035234Biological processectopic germ cell programmed cell death
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0032308Biological processpositive regulation of prostaglandin secretion
GO_0006915Biological processapoptotic process
GO_0046688Biological processresponse to copper ion
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0001819Biological processpositive regulation of cytokine production
GO_0001660Biological processfever generation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005149Molecular functioninterleukin-1 receptor binding
GO_0005507Molecular functioncopper ion binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL1A
Protein nameInterleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)
SynonymsIL1F1
DescriptionFUNCTION: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems . After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex . Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4 . In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways . Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage . In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as a signal for genotoxic stress without loss of cell integrity . .

AccessionsENST00000263339.4
P01583