Insufficient scRNA-seq data for expression of ADIPOQ at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 88% | 34239.67 | 403 / 459 | 56% | 19.90 | 624 / 1118 |
| adipose | 100% | 49208.30 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| skin | 20% | 587.90 | 366 / 1809 | 9% | 0.93 | 43 / 472 |
| pancreas | 6% | 110.02 | 20 / 328 | 21% | 5.16 | 38 / 178 |
| bladder | 19% | 237.43 | 4 / 21 | 8% | 1.06 | 39 / 504 |
| intestine | 15% | 592.80 | 145 / 966 | 5% | 1.21 | 25 / 527 |
| blood vessel | 16% | 1703.75 | 219 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 13% | 380.91 | 84 / 653 | 3% | 0.24 | 20 / 605 |
| adrenal gland | 15% | 355.71 | 38 / 258 | 1% | 0.76 | 3 / 230 |
| stomach | 7% | 443.11 | 24 / 359 | 9% | 1.38 | 25 / 286 |
| heart | 12% | 335.90 | 107 / 861 | 0% | 0 | 0 / 0 |
| ovary | 0% | 0 | 0 / 180 | 11% | 0.94 | 46 / 430 |
| muscle | 7% | 97.79 | 57 / 803 | 0% | 0 | 0 / 0 |
| esophagus | 5% | 273.00 | 75 / 1445 | 0% | 0 | 0 / 183 |
| kidney | 1% | 127.49 | 1 / 89 | 2% | 0.27 | 17 / 901 |
| prostate | 1% | 41.78 | 3 / 245 | 1% | 0.02 | 4 / 502 |
| uterus | 0% | 0 | 0 / 170 | 2% | 1.04 | 9 / 459 |
| lung | 0% | 0 | 0 / 578 | 2% | 0.24 | 19 / 1155 |
| liver | 0% | 0 | 0 / 226 | 0% | 0.07 | 2 / 406 |
| peripheral blood | 0% | 6.73 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| brain | 0% | 0 | 0 / 2642 | 0% | 0 | 0 / 705 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046888 | Biological process | negative regulation of hormone secretion |
| GO_0007584 | Biological process | response to nutrient |
| GO_0050873 | Biological process | brown fat cell differentiation |
| GO_0072659 | Biological process | protein localization to plasma membrane |
| GO_0071872 | Biological process | cellular response to epinephrine stimulus |
| GO_0014823 | Biological process | response to activity |
| GO_0034115 | Biological process | negative regulation of heterotypic cell-cell adhesion |
| GO_0071320 | Biological process | cellular response to cAMP |
| GO_0050728 | Biological process | negative regulation of inflammatory response |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0043407 | Biological process | negative regulation of MAP kinase activity |
| GO_2000478 | Biological process | positive regulation of metanephric podocyte development |
| GO_0031953 | Biological process | negative regulation of protein autophosphorylation |
| GO_0032720 | Biological process | negative regulation of tumor necrosis factor production |
| GO_0006006 | Biological process | glucose metabolic process |
| GO_0071466 | Biological process | cellular response to xenobiotic stimulus |
| GO_0070543 | Biological process | response to linoleic acid |
| GO_0009617 | Biological process | response to bacterium |
| GO_0007165 | Biological process | signal transduction |
| GO_0045599 | Biological process | negative regulation of fat cell differentiation |
| GO_0070994 | Biological process | detection of oxidative stress |
| GO_0009744 | Biological process | response to sucrose |
| GO_0010739 | Biological process | positive regulation of protein kinase A signaling |
| GO_0032757 | Biological process | positive regulation of interleukin-8 production |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0010467 | Biological process | gene expression |
| GO_1900121 | Biological process | negative regulation of receptor binding |
| GO_0010804 | Biological process | negative regulation of tumor necrosis factor-mediated signaling pathway |
| GO_2000534 | Biological process | positive regulation of renal albumin absorption |
| GO_2000481 | Biological process | positive regulation of cAMP-dependent protein kinase activity |
| GO_0043124 | Biological process | negative regulation of canonical NF-kappaB signal transduction |
| GO_0010642 | Biological process | negative regulation of platelet-derived growth factor receptor signaling pathway |
| GO_2000590 | Biological process | negative regulation of metanephric mesenchymal cell migration |
| GO_0032869 | Biological process | cellular response to insulin stimulus |
| GO_0045923 | Biological process | positive regulation of fatty acid metabolic process |
| GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0034612 | Biological process | response to tumor necrosis factor |
| GO_0045471 | Biological process | response to ethanol |
| GO_0010745 | Biological process | negative regulation of macrophage derived foam cell differentiation |
| GO_2000467 | Biological process | positive regulation of glycogen (starch) synthase activity |
| GO_0071639 | Biological process | positive regulation of monocyte chemotactic protein-1 production |
| GO_0006635 | Biological process | fatty acid beta-oxidation |
| GO_0033034 | Biological process | positive regulation of myeloid cell apoptotic process |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0120163 | Biological process | negative regulation of cold-induced thermogenesis |
| GO_0006091 | Biological process | generation of precursor metabolites and energy |
| GO_0046326 | Biological process | positive regulation of glucose import |
| GO_2000584 | Biological process | negative regulation of platelet-derived growth factor receptor-alpha signaling pathway |
| GO_0110113 | Biological process | positive regulation of lipid transporter activity |
| GO_0045721 | Biological process | negative regulation of gluconeogenesis |
| GO_0009749 | Biological process | response to glucose |
| GO_1904706 | Biological process | negative regulation of vascular associated smooth muscle cell proliferation |
| GO_0019395 | Biological process | fatty acid oxidation |
| GO_0009967 | Biological process | positive regulation of signal transduction |
| GO_0010906 | Biological process | regulation of glucose metabolic process |
| GO_0050805 | Biological process | negative regulation of synaptic transmission |
| GO_1905598 | Biological process | negative regulation of low-density lipoprotein receptor activity |
| GO_0007623 | Biological process | circadian rhythm |
| GO_0090317 | Biological process | negative regulation of intracellular protein transport |
| GO_0050765 | Biological process | negative regulation of phagocytosis |
| GO_0045650 | Biological process | negative regulation of macrophage differentiation |
| GO_0051384 | Biological process | response to glucocorticoid |
| GO_0045776 | Biological process | negative regulation of blood pressure |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0034383 | Biological process | low-density lipoprotein particle clearance |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0030853 | Biological process | negative regulation of granulocyte differentiation |
| GO_0010875 | Biological process | positive regulation of cholesterol efflux |
| GO_1904753 | Biological process | negative regulation of vascular associated smooth muscle cell migration |
| GO_2000279 | Biological process | negative regulation of DNA biosynthetic process |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0009986 | Cellular component | cell surface |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005581 | Cellular component | collagen trimer |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005201 | Molecular function | extracellular matrix structural constituent |
| GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
| GO_0033691 | Molecular function | sialic acid binding |
| GO_0005179 | Molecular function | hormone activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| Gene name | ADIPOQ |
| Protein name | Adiponectin (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte, C1q and collagen domain-containing protein) (Adipose most abundant gene transcript 1 protein) (apM-1) (Gelatin-binding protein) Adiponectin (cDNA FLJ78108, highly similar to Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), mRNA) |
| Synonyms | hCG_1784052 APM1 ACDC ACRP30 GBP28 |
| Description | FUNCTION: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. . |
| Accessions | ENST00000444204.2 Q15848 ENST00000320741.7 A8K660 |
