Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 99% | 5665.65 | 242 / 245 | 100% | 29.13 | 502 / 502 |
| lung | 99% | 6182.74 | 572 / 578 | 99% | 25.34 | 1140 / 1155 |
| thymus | 90% | 2684.94 | 587 / 653 | 100% | 48.05 | 604 / 605 |
| brain | 86% | 12874.00 | 2283 / 2642 | 100% | 29.27 | 702 / 705 |
| kidney | 87% | 2786.74 | 77 / 89 | 97% | 15.12 | 872 / 901 |
| bladder | 81% | 2130.33 | 17 / 21 | 96% | 18.66 | 482 / 504 |
| intestine | 77% | 4440.53 | 741 / 966 | 99% | 21.87 | 521 / 527 |
| skin | 90% | 6561.78 | 1629 / 1809 | 85% | 13.18 | 402 / 472 |
| breast | 76% | 2246.46 | 351 / 459 | 96% | 16.47 | 1068 / 1118 |
| uterus | 75% | 1849.65 | 127 / 170 | 90% | 19.60 | 413 / 459 |
| esophagus | 64% | 1942.64 | 932 / 1445 | 100% | 28.88 | 183 / 183 |
| stomach | 64% | 1772.31 | 228 / 359 | 98% | 24.09 | 281 / 286 |
| adrenal gland | 69% | 1762.08 | 179 / 258 | 78% | 17.19 | 179 / 230 |
| pancreas | 35% | 863.70 | 116 / 328 | 99% | 24.82 | 176 / 178 |
| liver | 45% | 959.06 | 101 / 226 | 56% | 5.34 | 227 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 65.71 | 29 / 29 |
| spleen | 100% | 15369.46 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 30.63 | 45 / 45 |
| peripheral blood | 100% | 23833.28 | 928 / 929 | 0% | 0 | 0 / 0 |
| ovary | 11% | 252.01 | 20 / 180 | 83% | 9.89 | 356 / 430 |
| adipose | 88% | 3200.38 | 1062 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 70% | 6.22 | 56 / 80 |
| blood vessel | 58% | 1747.68 | 779 / 1335 | 0% | 0 | 0 / 0 |
| heart | 21% | 584.52 | 182 / 861 | 0% | 0 | 0 / 0 |
| muscle | 4% | 128.75 | 36 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042542 | Biological process | response to hydrogen peroxide |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0071498 | Biological process | cellular response to fluid shear stress |
| GO_0035235 | Biological process | ionotropic glutamate receptor signaling pathway |
| GO_2000463 | Biological process | positive regulation of excitatory postsynaptic potential |
| GO_0001556 | Biological process | oocyte maturation |
| GO_0051591 | Biological process | response to cAMP |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_2000379 | Biological process | positive regulation of reactive oxygen species metabolic process |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0009612 | Biological process | response to mechanical stimulus |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0051592 | Biological process | response to calcium ion |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0071300 | Biological process | cellular response to retinoic acid |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0030838 | Biological process | positive regulation of actin filament polymerization |
| GO_0002931 | Biological process | response to ischemia |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0031175 | Biological process | neuron projection development |
| GO_0007165 | Biological process | signal transduction |
| GO_0014009 | Biological process | glial cell proliferation |
| GO_0060292 | Biological process | long-term synaptic depression |
| GO_0060291 | Biological process | long-term synaptic potentiation |
| GO_0009725 | Biological process | response to hormone |
| GO_0042220 | Biological process | response to cocaine |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_2000573 | Biological process | positive regulation of DNA biosynthetic process |
| GO_0045429 | Biological process | positive regulation of nitric oxide biosynthetic process |
| GO_0045453 | Biological process | bone resorption |
| GO_0045727 | Biological process | positive regulation of translation |
| GO_0051279 | Biological process | regulation of release of sequestered calcium ion into cytosol |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0045638 | Biological process | negative regulation of myeloid cell differentiation |
| GO_2000058 | Biological process | regulation of ubiquitin-dependent protein catabolic process |
| GO_0035902 | Biological process | response to immobilization stress |
| GO_0010758 | Biological process | regulation of macrophage chemotaxis |
| GO_0045471 | Biological process | response to ethanol |
| GO_2000538 | Biological process | positive regulation of B cell chemotaxis |
| GO_0002040 | Biological process | sprouting angiogenesis |
| GO_0002315 | Biological process | marginal zone B cell differentiation |
| GO_0043534 | Biological process | blood vessel endothelial cell migration |
| GO_0038083 | Biological process | peptidyl-tyrosine autophosphorylation |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0030502 | Biological process | negative regulation of bone mineralization |
| GO_0007172 | Biological process | signal complex assembly |
| GO_0043267 | Biological process | negative regulation of potassium ion transport |
| GO_0048041 | Biological process | focal adhesion assembly |
| GO_0048010 | Biological process | vascular endothelial growth factor receptor signaling pathway |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0033209 | Biological process | tumor necrosis factor-mediated signaling pathway |
| GO_0043157 | Biological process | response to cation stress |
| GO_0042976 | Biological process | activation of Janus kinase activity |
| GO_0009749 | Biological process | response to glucose |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0046330 | Biological process | positive regulation of JNK cascade |
| GO_0010595 | Biological process | positive regulation of endothelial cell migration |
| GO_0001954 | Biological process | positive regulation of cell-matrix adhesion |
| GO_0006968 | Biological process | cellular defense response |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0045860 | Biological process | positive regulation of protein kinase activity |
| GO_0030865 | Biological process | cortical cytoskeleton organization |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
| GO_0048167 | Biological process | regulation of synaptic plasticity |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0006915 | Biological process | apoptotic process |
| GO_0043149 | Biological process | stress fiber assembly |
| GO_0086100 | Biological process | endothelin receptor signaling pathway |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0051968 | Biological process | positive regulation of synaptic transmission, glutamatergic |
| GO_0099170 | Biological process | postsynaptic modulation of chemical synaptic transmission |
| GO_0030155 | Biological process | regulation of cell adhesion |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0010656 | Biological process | negative regulation of muscle cell apoptotic process |
| GO_0099151 | Biological process | regulation of postsynaptic density assembly |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098793 | Cellular component | presynapse |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0099092 | Cellular component | postsynaptic density, intracellular component |
| GO_0005634 | Cellular component | nucleus |
| GO_0030425 | Cellular component | dendrite |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0017146 | Cellular component | NMDA selective glutamate receptor complex |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005938 | Cellular component | cell cortex |
| GO_0030426 | Cellular component | growth cone |
| GO_0044297 | Cellular component | cell body |
| GO_0097440 | Cellular component | apical dendrite |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0035254 | Molecular function | glutamate receptor binding |
| GO_0099602 | Molecular function | neurotransmitter receptor regulator activity |
| GO_0004715 | Molecular function | non-membrane spanning protein tyrosine kinase activity |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0043423 | Molecular function | 3-phosphoinositide-dependent protein kinase binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0004683 | Molecular function | calmodulin-dependent protein kinase activity |
| Gene name | PTK2B |
| Protein name | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) Protein tyrosine kinase 2 beta |
| Synonyms | RAFTK FAK2 PYK2 |
| Description | FUNCTION: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. . |
| Accessions | E5RHL2 ENST00000521164.5 ENST00000397501.5 [Q14289-1] ENST00000420218.3 [Q14289-2] ENST00000522517.5 ENST00000517339.5 [Q14289-2] ENST00000519512.5 Q14289 ENST00000346049.10 [Q14289-1] C9JHV9 ENST00000412793.5 ENST00000522338.5 E5RJ77 E5RK84 H0YB74 |
