Genes | Cell types | No. of supported studies | |
|---|---|---|---|
| Group 1 | 5 studies | ||
| Group 2 | 8 studies | ||
| Group 3 | 14 studies | ||
| Group 4 | 7 studies | ||
| Group 5 | 85 studies |
Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | DLL1-NOTCH2 | DLL1_HUMAN - NOTC2_HUMAN | Ligand-Receptor | Signaling by Notch |
| Name | marginal zone B cell differentiation |
| ID | GO_0002315 |
| collection_id | Biological process |
| Exact synonym | marginal zone B lymphocyte differentiation, marginal zone B-cell differentiation, marginal zone B-lymphocyte differentiation |
| Description | The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). |
| Related synonym | marginal zone B cell development |
| Comment | Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. |
| External URL | |
| Genes |