MFNG | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	21% ± 5%	Explore
CD4-positive, alpha-beta T cell	17 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	14 studies	27% ± 8%	Explore
regulatory T cell	13 studies	24% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	27% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	28% ± 6%	Explore
T cell	9 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	24% ± 4%	Explore
gamma-delta T cell	9 studies	23% ± 7%	Explore
B cell	8 studies	18% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	23% ± 4%	Explore
mature NK T cell	8 studies	23% ± 7%	Explore
mucosal invariant T cell	8 studies	21% ± 3%	Explore
endothelial cell	7 studies	25% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	28% ± 4%	Explore
classical monocyte	5 studies	25% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	24% ± 3%	Explore
capillary endothelial cell	5 studies	21% ± 7%	Explore
naive B cell	5 studies	17% ± 2%	Explore
hematopoietic precursor cell	4 studies	26% ± 11%	Explore
non-classical monocyte	4 studies	31% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	34% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	26% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	31% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	30% ± 9%	Explore
memory B cell	4 studies	17% ± 0%	Explore
conventional dendritic cell	3 studies	36% ± 13%	Explore
exhausted T cell	3 studies	31% ± 11%	Explore
precursor B cell	3 studies	22% ± 2%	Explore
endothelial cell of vascular tree	3 studies	17% ± 1%	Explore
dendritic cell	3 studies	35% ± 15%	Explore
hematopoietic stem cell	3 studies	22% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 4%	Explore
double negative thymocyte	3 studies	25% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	23% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	99%	1047.54	648 / 653	100%	19.42	602 / 605
lung	100%	2484.68	578 / 578	97%	14.68	1117 / 1155
breast	100%	1500.20	459 / 459	95%	12.42	1061 / 1118
kidney	98%	821.61	87 / 89	96%	20.49	861 / 901
intestine	97%	1106.10	940 / 966	95%	11.37	502 / 527
uterus	99%	954.74	169 / 170	88%	8.24	402 / 459
prostate	96%	698.98	235 / 245	88%	6.68	440 / 502
stomach	88%	493.11	316 / 359	94%	11.22	269 / 286
adrenal gland	97%	669.07	251 / 258	83%	7.38	192 / 230
bladder	100%	886.33	21 / 21	79%	9.62	399 / 504
esophagus	94%	661.80	1357 / 1445	81%	7.44	149 / 183
liver	63%	304.61	143 / 226	87%	8.69	352 / 406
brain	44%	177.14	1158 / 2642	100%	23.51	705 / 705
skin	57%	278.47	1032 / 1809	86%	12.61	405 / 472
pancreas	38%	145.20	125 / 328	98%	19.78	174 / 178
ovary	49%	232.71	89 / 180	80%	6.63	342 / 430
lymph node	0%	0	0 / 0	100%	125.20	29 / 29
spleen	100%	5756.22	241 / 241	0%	0	0 / 0
adipose	100%	1658.08	1203 / 1204	0%	0	0 / 0
peripheral blood	100%	4051.22	928 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	14.18	43 / 45
heart	94%	640.88	809 / 861	0%	0	0 / 0
blood vessel	70%	474.71	934 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	39%	2.37	31 / 80
muscle	28%	90.13	224 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0008593	Biological process	regulation of Notch signaling pathway
GO_0045747	Biological process	positive regulation of Notch signaling pathway
GO_0001825	Biological process	blastocyst formation
GO_0007389	Biological process	pattern specification process
GO_0002315	Biological process	marginal zone B cell differentiation
GO_0005615	Cellular component	extracellular space
GO_0000139	Cellular component	Golgi membrane
GO_0033829	Molecular function	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	MFNG
Protein name	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Beta-1,3-N-acetylglucosaminyltransferase manic fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)
Synonyms	CTA-390B3.2-010 CTA-390B3.2-005 CTA-390B3.2-007 CTA-390B3.2-004
Description	FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). .
Accessions	ENST00000416983.7 [O00587-2] F8WE21 A0A1B0GX02 O00587 ENST00000356998.8 [O00587-1] A9UJQ0 ENST00000436341.5 A9UJQ2 F8WE05 ENST00000438891.5 H0Y6Q9 A9UJP9 A9UJQ1 ENST00000442496.1 ENST00000424765.2 ENST00000430411.1 ENST00000454291.1

MFNG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review