LFNG | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of LFNG at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	3883.58	328 / 328	96%	85.10	171 / 178
brain	94%	1131.76	2480 / 2642	98%	112.68	688 / 705
stomach	95%	1645.49	341 / 359	96%	85.19	275 / 286
prostate	94%	1780.67	230 / 245	97%	84.96	487 / 502
intestine	89%	1580.66	858 / 966	97%	101.49	513 / 527
breast	98%	1402.24	451 / 459	86%	63.06	962 / 1118
lung	99%	1424.61	572 / 578	79%	45.39	908 / 1155
esophagus	86%	725.81	1237 / 1445	75%	35.27	138 / 183
bladder	81%	1200.19	17 / 21	73%	50.39	370 / 504
uterus	92%	1038.89	157 / 170	60%	27.51	277 / 459
kidney	76%	730.11	68 / 89	49%	18.00	444 / 901
adrenal gland	84%	575.24	217 / 258	35%	11.57	80 / 230
skin	89%	2643.97	1613 / 1809	22%	7.08	105 / 472
thymus	81%	676.73	530 / 653	23%	5.18	142 / 605
spleen	100%	2064.65	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	73.03	1 / 1
adipose	98%	1472.28	1182 / 1204	0%	0	0 / 0
peripheral blood	82%	2275.06	762 / 929	0%	0	0 / 0
ovary	14%	90.22	26 / 180	43%	13.23	187 / 430
tonsil	0%	0	0 / 0	58%	17.72	26 / 45
lymph node	0%	0	0 / 0	55%	18.91	16 / 29
heart	52%	320.84	448 / 861	0%	0	0 / 0
blood vessel	44%	332.92	591 / 1335	0%	0	0 / 0
liver	8%	40.63	17 / 226	10%	4.08	40 / 406
eye	0%	0	0 / 0	5%	1.16	4 / 80
muscle	4%	19.07	34 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0051446	Biological process	positive regulation of meiotic cell cycle
GO_0030217	Biological process	T cell differentiation
GO_0007386	Biological process	compartment pattern specification
GO_0008593	Biological process	regulation of Notch signaling pathway
GO_1902367	Biological process	negative regulation of Notch signaling pathway involved in somitogenesis
GO_0045747	Biological process	positive regulation of Notch signaling pathway
GO_0009887	Biological process	animal organ morphogenesis
GO_0014807	Biological process	regulation of somitogenesis
GO_0001756	Biological process	somitogenesis
GO_0001541	Biological process	ovarian follicle development
GO_0002315	Biological process	marginal zone B cell differentiation
GO_0000139	Cellular component	Golgi membrane
GO_1903561	Cellular component	extracellular vesicle
GO_0005576	Cellular component	extracellular region
GO_0033829	Molecular function	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO_0046872	Molecular function	metal ion binding

Gene name	LFNG
Protein name	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)
Synonyms
Description	FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 . Essential mediator of somite segmentation and patterning (By similarity). .
Accessions	Q8NES3 ENST00000222725.10 [Q8NES3-1] ENST00000338732.7 [Q8NES3-2] ENST00000402045.5 [Q8NES3-2] ENST00000402506.5 [Q8NES3-4] ENST00000359574.7 [Q8NES3-3]

LFNG report