NOTCH2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	21 studies	25% ± 9%	Explore
fibroblast	20 studies	26% ± 8%	Explore
non-classical monocyte	18 studies	29% ± 11%	Explore
macrophage	17 studies	29% ± 15%	Explore
astrocyte	16 studies	39% ± 18%	Explore
pericyte	13 studies	28% ± 12%	Explore
monocyte	10 studies	31% ± 10%	Explore
oligodendrocyte precursor cell	10 studies	36% ± 14%	Explore
dendritic cell	9 studies	28% ± 11%	Explore
B cell	9 studies	20% ± 4%	Explore
microglial cell	8 studies	31% ± 13%	Explore
myeloid cell	7 studies	29% ± 6%	Explore
adipocyte	7 studies	31% ± 8%	Explore
epithelial cell	6 studies	35% ± 17%	Explore
conventional dendritic cell	5 studies	23% ± 6%	Explore
myofibroblast cell	5 studies	22% ± 7%	Explore
connective tissue cell	5 studies	24% ± 8%	Explore
Mueller cell	5 studies	30% ± 12%	Explore
club cell	5 studies	23% ± 7%	Explore
type I pneumocyte	5 studies	22% ± 7%	Explore
smooth muscle cell	5 studies	20% ± 4%	Explore
plasmacytoid dendritic cell	5 studies	23% ± 7%	Explore
endothelial cell	4 studies	35% ± 9%	Explore
memory B cell	4 studies	22% ± 4%	Explore
naive B cell	4 studies	24% ± 4%	Explore
retinal pigment epithelial cell	4 studies	36% ± 18%	Explore
mononuclear phagocyte	4 studies	28% ± 6%	Explore
hepatocyte	4 studies	46% ± 19%	Explore
progenitor cell	3 studies	23% ± 6%	Explore
podocyte	3 studies	28% ± 4%	Explore
abnormal cell	3 studies	29% ± 9%	Explore
ciliated cell	3 studies	26% ± 10%	Explore
ependymal cell	3 studies	42% ± 19%	Explore
alveolar macrophage	3 studies	27% ± 9%	Explore
chondrocyte	3 studies	24% ± 6%	Explore
respiratory goblet cell	3 studies	26% ± 14%	Explore
basal cell	3 studies	33% ± 12%	Explore
mast cell	3 studies	20% ± 4%	Explore
glutamatergic neuron	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	7 studies	20% ± 4%	Explore
lung	5 studies	20% ± 5%	Explore
peripheral blood	4 studies	19% ± 3%	Explore
liver	4 studies	16% ± 1%	Explore
adipose	4 studies	24% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	12001.32	180 / 180	100%	39.33	429 / 430
prostate	100%	9019.32	245 / 245	99%	34.97	498 / 502
breast	100%	11112.98	459 / 459	99%	52.65	1108 / 1118
esophagus	100%	10512.35	1445 / 1445	98%	31.80	180 / 183
skin	100%	20887.65	1809 / 1809	97%	41.86	458 / 472
lung	100%	11578.36	577 / 578	97%	27.49	1118 / 1155
thymus	100%	9716.68	652 / 653	96%	35.58	582 / 605
uterus	100%	11248.81	170 / 170	95%	25.77	438 / 459
intestine	100%	7951.61	964 / 966	90%	15.81	473 / 527
bladder	100%	8827.29	21 / 21	84%	16.01	424 / 504
pancreas	91%	4068.14	299 / 328	92%	22.53	164 / 178
stomach	89%	4818.25	320 / 359	92%	18.81	263 / 286
kidney	89%	3911.42	79 / 89	88%	24.84	790 / 901
brain	66%	2933.96	1741 / 2642	99%	35.33	698 / 705
liver	97%	4103.35	219 / 226	64%	11.86	260 / 406
adrenal gland	98%	7180.80	254 / 258	27%	4.03	63 / 230
adipose	100%	11612.27	1204 / 1204	0%	0	0 / 0
blood vessel	100%	18456.91	1335 / 1335	0%	0	0 / 0
spleen	100%	11379.05	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	27.72	42 / 45
eye	0%	0	0 / 0	83%	12.18	66 / 80
heart	82%	4129.47	709 / 861	0%	0	0 / 0
peripheral blood	81%	7744.52	748 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	76%	12.99	22 / 29
muscle	45%	1412.98	363 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071228	Biological process	cellular response to tumor cell
GO_0070986	Biological process	left/right axis specification
GO_0030097	Biological process	hemopoiesis
GO_0035622	Biological process	intrahepatic bile duct development
GO_0002011	Biological process	morphogenesis of an epithelial sheet
GO_0001701	Biological process	in utero embryonic development
GO_0001709	Biological process	cell fate determination
GO_0010629	Biological process	negative regulation of gene expression
GO_0007219	Biological process	Notch signaling pathway
GO_0072014	Biological process	proximal tubule development
GO_0001947	Biological process	heart looping
GO_0009887	Biological process	animal organ morphogenesis
GO_0035264	Biological process	multicellular organism growth
GO_0060413	Biological process	atrial septum morphogenesis
GO_0010838	Biological process	positive regulation of keratinocyte proliferation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0051152	Biological process	positive regulation of smooth muscle cell differentiation
GO_0002437	Biological process	inflammatory response to antigenic stimulus
GO_1990705	Biological process	cholangiocyte proliferation
GO_0006959	Biological process	humoral immune response
GO_0042060	Biological process	wound healing
GO_0002315	Biological process	marginal zone B cell differentiation
GO_0045672	Biological process	positive regulation of osteoclast differentiation
GO_0030509	Biological process	BMP signaling pathway
GO_0061073	Biological process	ciliary body morphogenesis
GO_0072104	Biological process	glomerular capillary formation
GO_0035556	Biological process	intracellular signal transduction
GO_0046849	Biological process	bone remodeling
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0060674	Biological process	placenta blood vessel development
GO_0030326	Biological process	embryonic limb morphogenesis
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_2001204	Biological process	regulation of osteoclast development
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0043011	Biological process	myeloid dendritic cell differentiation
GO_0072015	Biological process	podocyte development
GO_0042742	Biological process	defense response to bacterium
GO_0072574	Biological process	hepatocyte proliferation
GO_0046579	Biological process	positive regulation of Ras protein signal transduction
GO_0006915	Biological process	apoptotic process
GO_0003184	Biological process	pulmonary valve morphogenesis
GO_0003162	Biological process	atrioventricular node development
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0007399	Biological process	nervous system development
GO_0007411	Biological process	axon guidance
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0009986	Cellular component	cell surface
GO_0000139	Cellular component	Golgi membrane
GO_0005929	Cellular component	cilium
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0038023	Molecular function	signaling receptor activity
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000987	Molecular function	cis-regulatory region sequence-specific DNA binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0051059	Molecular function	NF-kappaB binding

IV. Literature review

[source]

Gene name	NOTCH2
Protein name	Neurogenic locus notch-like protein 2 NOTCH2 protein Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] Notch receptor 2
Synonyms
Description	FUNCTION: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells . .
Accessions	A0A494C1F1 ENST00000651371.1 A0A1W2PQQ5 D2WEZ3 ENST00000652737.1 ENST00000640021.1 ENST00000256646.7 A0A494C1U9 A0A494C049 ENST00000652302.1 ENST00000652264.1 Q6IQ50 Q04721 A0A494C1H8

NOTCH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review