DLL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DLL1 at tissue level.

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0021510Biological processspinal cord development
GO_0001947Biological processheart looping
GO_0045662Biological processnegative regulation of myoblast differentiation
GO_0042491Biological processinner ear auditory receptor cell differentiation
GO_0045605Biological processnegative regulation of epidermal cell differentiation
GO_1903672Biological processpositive regulation of sprouting angiogenesis
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0002085Biological processinhibition of neuroepithelial cell differentiation
GO_0051302Biological processregulation of cell division
GO_0030947Biological processregulation of vascular endothelial growth factor receptor signaling pathway
GO_2000726Biological processnegative regulation of cardiac muscle cell differentiation
GO_0030857Biological processnegative regulation of epithelial cell differentiation
GO_0060042Biological processretina morphogenesis in camera-type eye
GO_0048633Biological processpositive regulation of skeletal muscle tissue growth
GO_0003323Biological processtype B pancreatic cell development
GO_0021693Biological processcerebellar Purkinje cell layer structural organization
GO_0014002Biological processastrocyte development
GO_0050767Biological processregulation of neurogenesis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0009954Biological processproximal/distal pattern formation
GO_0070986Biological processleft/right axis specification
GO_0097150Biological processneuronal stem cell population maintenance
GO_0007219Biological processNotch signaling pathway
GO_0001709Biological processcell fate determination
GO_0007368Biological processdetermination of left/right symmetry
GO_0008217Biological processregulation of blood pressure
GO_0010628Biological processpositive regulation of gene expression
GO_0007386Biological processcompartment pattern specification
GO_0048665Biological processneuron fate specification
GO_0021688Biological processcerebellar molecular layer formation
GO_0045611Biological processnegative regulation of hemocyte differentiation
GO_0098773Biological processskin epidermis development
GO_0060853Biological processNotch signaling pathway involved in arterial endothelial cell fate commitment
GO_0034351Biological processnegative regulation of glial cell apoptotic process
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0014807Biological processregulation of somitogenesis
GO_0035265Biological processorgan growth
GO_0045638Biological processnegative regulation of myeloid cell differentiation
GO_0030097Biological processhemopoiesis
GO_0072014Biological processproximal tubule development
GO_1900746Biological processregulation of vascular endothelial growth factor signaling pathway
GO_0097102Biological processendothelial tip cell fate specification
GO_0045807Biological processpositive regulation of endocytosis
GO_0001757Biological processsomite specification
GO_0002315Biological processmarginal zone B cell differentiation
GO_0030099Biological processmyeloid cell differentiation
GO_0072006Biological processnephron development
GO_0045608Biological processnegative regulation of inner ear auditory receptor cell differentiation
GO_0001756Biological processsomitogenesis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0046331Biological processlateral inhibition
GO_0072583Biological processclathrin-dependent endocytosis
GO_0040008Biological processregulation of growth
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0060041Biological processretina development in camera-type eye
GO_0072070Biological processloop of Henle development
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0060563Biological processneuroepithelial cell differentiation
GO_0030154Biological processcell differentiation
GO_0045596Biological processnegative regulation of cell differentiation
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0048630Biological processskeletal muscle tissue growth
GO_0030155Biological processregulation of cell adhesion
GO_0048631Biological processregulation of skeletal muscle tissue growth
GO_0045121Cellular componentmembrane raft
GO_0005576Cellular componentextracellular region
GO_0005912Cellular componentadherens junction
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016324Cellular componentapical plasma membrane
GO_0048018Molecular functionreceptor ligand activity
GO_0005112Molecular functionNotch binding
GO_0097110Molecular functionscaffold protein binding
GO_0005509Molecular functioncalcium ion binding
GO_0030957Molecular functionTat protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDLL1
Protein nameDelta like canonical Notch ligand 1 (Delta-like protein 1)
Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1)
SynonymsUNQ146/PRO172
DescriptionFUNCTION: Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner . Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation . Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B-cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor . Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation through regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity). .

AccessionsO00548
ENST00000630365.1
ENST00000616526.2 [O00548-1]
ENST00000630500.1
ENST00000366756.4 [O00548-1]
A0A0D9SF76