LEP report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LEP at tissue level.

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0050796Biological processregulation of insulin secretion
GO_0035360Biological processpositive regulation of peroxisome proliferator activated receptor signaling pathway
GO_0050999Biological processregulation of nitric-oxide synthase activity
GO_0043270Biological processpositive regulation of monoatomic ion transport
GO_0014823Biological processresponse to activity
GO_0002021Biological processresponse to dietary excess
GO_0043066Biological processnegative regulation of apoptotic process
GO_1900015Biological processregulation of cytokine production involved in inflammatory response
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0001666Biological processresponse to hypoxia
GO_0042755Biological processeating behavior
GO_0006909Biological processphagocytosis
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0030073Biological processinsulin secretion
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0042445Biological processhormone metabolic process
GO_0032008Biological processpositive regulation of TOR signaling
GO_0006006Biological processglucose metabolic process
GO_0001936Biological processregulation of endothelial cell proliferation
GO_0051726Biological processregulation of cell cycle
GO_0033686Biological processpositive regulation of luteinizing hormone secretion
GO_0071300Biological processcellular response to retinoic acid
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0001525Biological processangiogenesis
GO_0035904Biological processaorta development
GO_0030300Biological processregulation of intestinal cholesterol absorption
GO_0046850Biological processregulation of bone remodeling
GO_0090335Biological processregulation of brown fat cell differentiation
GO_0008217Biological processregulation of blood pressure
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0003300Biological processcardiac muscle hypertrophy
GO_0007565Biological processfemale pregnancy
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0033197Biological processresponse to vitamin E
GO_0045765Biological processregulation of angiogenesis
GO_0060587Biological processregulation of lipoprotein lipid oxidation
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0021954Biological processcentral nervous system neuron development
GO_0050901Biological processleukocyte tethering or rolling
GO_0045906Biological processnegative regulation of vasoconstriction
GO_0046881Biological processpositive regulation of follicle-stimulating hormone secretion
GO_0006629Biological processlipid metabolic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_1990051Biological processactivation of protein kinase C activity
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0032099Biological processnegative regulation of appetite
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0032355Biological processresponse to estradiol
GO_0038108Biological processnegative regulation of appetite by leptin-mediated signaling pathway
GO_0008206Biological processbile acid metabolic process
GO_0032869Biological processcellular response to insulin stimulus
GO_0001542Biological processovulation from ovarian follicle
GO_0071298Biological processcellular response to L-ascorbic acid
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0006114Biological processglycerol biosynthetic process
GO_0045471Biological processresponse to ethanol
GO_0042269Biological processregulation of natural killer cell mediated cytotoxicity
GO_0006111Biological processregulation of gluconeogenesis
GO_0070093Biological processnegative regulation of glucagon secretion
GO_0050810Biological processregulation of steroid biosynthetic process
GO_0030217Biological processT cell differentiation
GO_0044320Biological processcellular response to leptin stimulus
GO_0033210Biological processleptin-mediated signaling pathway
GO_0050892Biological processintestinal absorption
GO_0019953Biological processsexual reproduction
GO_0046628Biological processpositive regulation of insulin receptor signaling pathway
GO_0060612Biological processadipose tissue development
GO_0006635Biological processfatty acid beta-oxidation
GO_0051541Biological processelastin metabolic process
GO_0010888Biological processnegative regulation of lipid storage
GO_2000491Biological processpositive regulation of hepatic stellate cell activation
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0032814Biological processregulation of natural killer cell activation
GO_1904651Biological processpositive regulation of fat cell apoptotic process
GO_0032310Biological processprostaglandin secretion
GO_0007260Biological processtyrosine phosphorylation of STAT protein
GO_0008340Biological processdetermination of adult lifespan
GO_2000486Biological processnegative regulation of glutamine transport
GO_0008203Biological processcholesterol metabolic process
GO_0008343Biological processadult feeding behavior
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0048639Biological processpositive regulation of developmental growth
GO_0032868Biological processresponse to insulin
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0001890Biological processplacenta development
GO_0007623Biological processcircadian rhythm
GO_0035556Biological processintracellular signal transduction
GO_0098868Biological processbone growth
GO_0010507Biological processnegative regulation of autophagy
GO_0032817Biological processregulation of natural killer cell proliferation
GO_0035630Biological processbone mineralization involved in bone maturation
GO_0006112Biological processenergy reserve metabolic process
GO_0061037Biological processnegative regulation of cartilage development
GO_0042593Biological processglucose homeostasis
GO_0046325Biological processnegative regulation of glucose import
GO_0005576Cellular componentextracellular region
GO_0005615Cellular componentextracellular space
GO_0005829Cellular componentcytosol
GO_1990460Molecular functionleptin receptor binding
GO_0005179Molecular functionhormone activity
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0051428Molecular functionpeptide hormone receptor binding

IV. Literature review

[source]
Gene nameLEP
Protein nameLeptin (Obese protein) (Obesity factor)
Leptin (Obesity factor)
SynonymsOBS
OB
hCG_33000
tcag7.84
DescriptionFUNCTION: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation. .

FUNCTION: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways . In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) . In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption . Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity) . May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression . Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) . In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells . Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 . In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation . .

FUNCTION: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation. .

AccessionsENST00000308868.5
D3HIE0
A4D0Y8
Q6NT58
P41159