NGB report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NGB at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NGB at tissue level.

III. Associated gene sets

GO_0015671Biological processoxygen transport
GO_0001666Biological processresponse to hypoxia
GO_0071456Biological processcellular response to hypoxia
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005344Molecular functionoxygen carrier activity
GO_0019825Molecular functionoxygen binding
GO_0005092Molecular functionGDP-dissociation inhibitor activity
GO_0098809Molecular functionnitrite reductase activity
GO_0020037Molecular functionheme binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameNGB
Protein nameNeuroglobin
Neuroglobin (Nitrite reductase) (EC 1.7.-.-)
SynonymshCG_22274
GLNH
DescriptionFUNCTION: Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide . Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it . The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia . In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress . .

AccessionsENST00000298352.5
Q9NPG2
A0M8W9