P2RX2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of P2RX2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of P2RX2 at tissue level.

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0002931Biological processresponse to ischemia
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0010524Biological processpositive regulation of calcium ion transport into cytosol
GO_0033198Biological processresponse to ATP
GO_0060079Biological processexcitatory postsynaptic potential
GO_0003029Biological processdetection of hypoxic conditions in blood by carotid body chemoreceptor signaling
GO_0048741Biological processskeletal muscle fiber development
GO_0035590Biological processpurinergic nucleotide receptor signaling pathway
GO_0007274Biological processneuromuscular synaptic transmission
GO_0007528Biological processneuromuscular junction development
GO_0050909Biological processsensory perception of taste
GO_0014832Biological processurinary bladder smooth muscle contraction
GO_0001666Biological processresponse to hypoxia
GO_0009743Biological processresponse to carbohydrate
GO_0048266Biological processbehavioral response to pain
GO_0030432Biological processperistalsis
GO_0070588Biological processcalcium ion transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0098992Cellular componentneuronal dense core vesicle
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0098794Cellular componentpostsynapse
GO_0043025Cellular componentneuronal cell body
GO_0001614Molecular functionpurinergic nucleotide receptor activity
GO_0015276Molecular functionligand-gated monoatomic ion channel activity
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0004931Molecular functionextracellularly ATP-gated monoatomic cation channel activity

IV. Literature review

[source]
Gene nameP2RX2
Protein nameATP receptor (Purinergic receptor)
P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor)
SynonymsP2X2
DescriptionFUNCTION: Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. .

AccessionsENST00000449132.6 [Q9UBL9-7]
ENST00000350048.9 [Q9UBL9-3]
ENST00000352418.8 [Q9UBL9-6]
ENST00000348800.9 [Q9UBL9-2]
ENST00000343948.8 [Q9UBL9-4]
Q32MC3
ENST00000542301.2
ENST00000351222.8 [Q9UBL9-5]
Q9UBL9
ENST00000643471.2 [Q9UBL9-1]