PENK report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PENK at tissue level.

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0032355Biological processresponse to estradiol
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0007218Biological processneuropeptide signaling pathway
GO_0051867Biological processgeneral adaptation syndrome, behavioral process
GO_0001649Biological processosteoblast differentiation
GO_0071305Biological processcellular response to vitamin D
GO_0007165Biological processsignal transduction
GO_0035902Biological processresponse to immobilization stress
GO_0002118Biological processaggressive behavior
GO_2000987Biological processpositive regulation of behavioral fear response
GO_0007600Biological processsensory perception
GO_0045471Biological processresponse to ethanol
GO_0071871Biological processresponse to epinephrine
GO_0098586Biological processcellular response to virus
GO_0099538Biological processsynaptic signaling via neuropeptide
GO_0071320Biological processcellular response to cAMP
GO_0034599Biological processcellular response to oxidative stress
GO_0007268Biological processchemical synaptic transmission
GO_0001666Biological processresponse to hypoxia
GO_0035094Biological processresponse to nicotine
GO_0001662Biological processbehavioral fear response
GO_0001964Biological processstartle response
GO_0019226Biological processtransmission of nerve impulse
GO_0009636Biological processresponse to toxic substance
GO_0035641Biological processlocomotory exploration behavior
GO_0038003Biological processG protein-coupled opioid receptor signaling pathway
GO_0051592Biological processresponse to calcium ion
GO_0014009Biological processglial cell proliferation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0034466Cellular componentchromaffin granule lumen
GO_0099013Cellular componentneuronal dense core vesicle lumen
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0043204Cellular componentperikaryon
GO_0070852Cellular componentcell body fiber
GO_0034592Cellular componentsynaptic vesicle lumen
GO_0043679Cellular componentaxon terminus
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0032280Cellular componentsymmetric synapse
GO_0001515Molecular functionopioid peptide activity
GO_0031628Molecular functionopioid receptor binding
GO_0005184Molecular functionneuropeptide hormone activity

IV. Literature review

[source]
Gene namePENK
Protein nameProenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-183); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(237-258); Met-enkephalin-Arg-Phe]
Proenkephalin-A
Synonyms
DescriptionFUNCTION: [Met-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: [Leu-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .; FUNCTION: [Met-enkephalin-Arg-Phe]: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release. .; FUNCTION: [PENK(114-133)]: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. .; FUNCTION: [PENK(237-258)]: Increases glutamate release in the striatum. .

FUNCTION: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. .; FUNCTION: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .

FUNCTION: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. .; FUNCTION: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .

FUNCTION: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. .; FUNCTION: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .

FUNCTION: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. .; FUNCTION: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .

FUNCTION: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. .; FUNCTION: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. .

AccessionsE5RIP6
ENST00000314922.3
ENST00000518770.1
E5RFR1
Q3B7B1
P01210
ENST00000517415.1
E5RJ72
H0YBT5
ENST00000523051.5
ENST00000518974.5
ENST00000451791.7