Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 11 studies | 26% ± 10% | |
| endothelial cell of artery | 7 studies | 27% ± 6% | |
| vein endothelial cell | 6 studies | 26% ± 11% | |
| endothelial cell of vascular tree | 3 studies | 32% ± 21% | |
| fibroblast | 3 studies | 29% ± 8% |
Insufficient scRNA-seq data for expression of VEGFC at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2588.36 | 652 / 653 | 96% | 65.82 | 582 / 605 |
| breast | 100% | 1716.97 | 459 / 459 | 96% | 14.03 | 1069 / 1118 |
| adrenal gland | 97% | 626.05 | 249 / 258 | 87% | 14.70 | 199 / 230 |
| prostate | 98% | 542.89 | 240 / 245 | 85% | 8.11 | 426 / 502 |
| lung | 100% | 1608.99 | 577 / 578 | 78% | 10.57 | 906 / 1155 |
| bladder | 100% | 961.43 | 21 / 21 | 75% | 15.80 | 376 / 504 |
| esophagus | 87% | 518.08 | 1262 / 1445 | 79% | 14.65 | 145 / 183 |
| ovary | 90% | 556.69 | 162 / 180 | 73% | 8.44 | 314 / 430 |
| uterus | 99% | 903.45 | 169 / 170 | 63% | 12.93 | 291 / 459 |
| kidney | 81% | 421.96 | 72 / 89 | 82% | 16.16 | 736 / 901 |
| skin | 86% | 1355.18 | 1547 / 1809 | 56% | 6.68 | 264 / 472 |
| intestine | 82% | 492.76 | 789 / 966 | 49% | 4.89 | 260 / 527 |
| stomach | 44% | 214.30 | 159 / 359 | 62% | 6.72 | 178 / 286 |
| liver | 45% | 151.59 | 101 / 226 | 56% | 4.88 | 229 / 406 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.45 | 1 / 1 |
| adipose | 100% | 2052.54 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 4% | 12.75 | 14 / 328 | 93% | 15.11 | 166 / 178 |
| heart | 93% | 586.50 | 802 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 8.70 | 27 / 29 |
| spleen | 88% | 365.32 | 212 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 75% | 430.96 | 1000 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 8.89 | 27 / 45 |
| eye | 0% | 0 | 0 / 0 | 39% | 4.37 | 31 / 80 |
| muscle | 34% | 110.08 | 270 / 803 | 0% | 0 | 0 / 0 |
| brain | 19% | 59.10 | 515 / 2642 | 12% | 0.98 | 82 / 705 |
| peripheral blood | 0% | 0.26 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002052 | Biological process | positive regulation of neuroblast proliferation |
| GO_0051781 | Biological process | positive regulation of cell division |
| GO_0060754 | Biological process | positive regulation of mast cell chemotaxis |
| GO_0043536 | Biological process | positive regulation of blood vessel endothelial cell migration |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0060252 | Biological process | positive regulation of glial cell proliferation |
| GO_0050918 | Biological process | positive chemotaxis |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_0007165 | Biological process | signal transduction |
| GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
| GO_1902462 | Biological process | positive regulation of mesenchymal stem cell proliferation |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0038084 | Biological process | vascular endothelial growth factor signaling pathway |
| GO_0016331 | Biological process | morphogenesis of embryonic epithelium |
| GO_1901492 | Biological process | positive regulation of lymphangiogenesis |
| GO_0002040 | Biological process | sprouting angiogenesis |
| GO_0030947 | Biological process | regulation of vascular endothelial growth factor receptor signaling pathway |
| GO_0050714 | Biological process | positive regulation of protein secretion |
| GO_0045776 | Biological process | negative regulation of blood pressure |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0006929 | Biological process | substrate-dependent cell migration |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0045668 | Biological process | negative regulation of osteoblast differentiation |
| GO_0031954 | Biological process | positive regulation of protein autophosphorylation |
| GO_0048010 | Biological process | vascular endothelial growth factor receptor signaling pathway |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0050930 | Biological process | induction of positive chemotaxis |
| GO_0014009 | Biological process | glial cell proliferation |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0016020 | Cellular component | membrane |
| GO_0031093 | Cellular component | platelet alpha granule lumen |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0042056 | Molecular function | chemoattractant activity |
| GO_0043185 | Molecular function | vascular endothelial growth factor receptor 3 binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | VEGFC |
| Protein name | VEGFC protein Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP) |
| Synonyms | |
| Description | FUNCTION: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. . |
| Accessions | ENST00000618562.2 P49767 Q6FH59 |
