I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 4 studies | 23% ± 6% | |
| epithelial cell | 3 studies | 29% ± 8% | |
| glutamatergic neuron | 3 studies | 25% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 4 studies | 23% ± 6% | |
| epithelial cell | 3 studies | 29% ± 8% | |
| glutamatergic neuron | 3 studies | 25% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 19% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 1525.63 | 258 / 258 | 100% | 44.14 | 230 / 230 |
| ovary | 100% | 2546.20 | 180 / 180 | 100% | 42.05 | 430 / 430 |
| thymus | 100% | 2176.46 | 653 / 653 | 100% | 55.61 | 605 / 605 |
| uterus | 100% | 2397.16 | 170 / 170 | 100% | 64.16 | 459 / 459 |
| skin | 100% | 1759.31 | 1809 / 1809 | 100% | 45.82 | 471 / 472 |
| stomach | 100% | 1406.71 | 359 / 359 | 100% | 33.12 | 285 / 286 |
| brain | 100% | 1389.02 | 2631 / 2642 | 100% | 35.50 | 705 / 705 |
| breast | 100% | 1817.81 | 459 / 459 | 99% | 44.50 | 1112 / 1118 |
| esophagus | 100% | 1556.98 | 1445 / 1445 | 99% | 31.02 | 182 / 183 |
| intestine | 100% | 1716.98 | 966 / 966 | 99% | 34.68 | 524 / 527 |
| prostate | 100% | 1680.86 | 245 / 245 | 99% | 30.89 | 499 / 502 |
| lung | 100% | 1627.70 | 578 / 578 | 99% | 33.83 | 1148 / 1155 |
| pancreas | 99% | 1033.90 | 326 / 328 | 100% | 38.19 | 178 / 178 |
| kidney | 100% | 1382.33 | 89 / 89 | 99% | 30.88 | 894 / 901 |
| bladder | 100% | 1806.14 | 21 / 21 | 99% | 43.21 | 498 / 504 |
| liver | 96% | 547.00 | 216 / 226 | 100% | 24.21 | 404 / 406 |
| adipose | 100% | 1621.80 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1805.54 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 52.43 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 47.46 | 29 / 29 |
| spleen | 100% | 1945.56 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 60.86 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 25.14 | 1 / 1 |
| muscle | 100% | 1024.04 | 799 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 1630.31 | 918 / 929 | 0% | 0 | 0 / 0 |
| heart | 99% | 904.34 | 850 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0050882 | Biological process | voluntary musculoskeletal movement |
| GO_0006303 | Biological process | double-strand break repair via nonhomologous end joining |
| GO_1990414 | Biological process | replication-born double-strand break repair via sister chromatid exchange |
| GO_0021766 | Biological process | hippocampus development |
| GO_0000012 | Biological process | single strand break repair |
| GO_0033194 | Biological process | response to hydroperoxide |
| GO_1903518 | Biological process | positive regulation of single strand break repair |
| GO_0010836 | Biological process | negative regulation of protein ADP-ribosylation |
| GO_0001666 | Biological process | response to hypoxia |
| GO_1905765 | Biological process | negative regulation of protection from non-homologous end joining at telomere |
| GO_0021587 | Biological process | cerebellum morphogenesis |
| GO_1904877 | Biological process | positive regulation of DNA ligase activity |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0006284 | Biological process | base-excision repair |
| GO_0061819 | Biological process | telomeric DNA-containing double minutes formation |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0070522 | Cellular component | ERCC4-ERCC1 complex |
| GO_0090734 | Cellular component | site of DNA damage |
| GO_0000781 | Cellular component | chromosome, telomeric region |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0160002 | Molecular function | ADP-D-ribose modification-dependent protein binding |
| GO_0072572 | Molecular function | poly-ADP-D-ribose binding |
| GO_1990599 | Molecular function | 3' overhang single-stranded DNA endodeoxyribonuclease activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0032356 | Molecular function | oxidized DNA binding |
| Gene name | XRCC1 |
| Protein name | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) X-ray cross-complementing group 1 protein X-ray repair cross complementing 1 X-ray cross-complementing group 1 |
| Synonyms | |
| Description | FUNCTION: Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes . Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity . Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity . . |
| Accessions | L7QJP1 ENST00000543982.5 M0QZ96 M0R1U8 V9VB20 ENST00000598165.5 ENST00000599693.5 M0R0D2 ENST00000594107.1 P18887 F5H8D7 ENST00000262887.10 M4WET6 M4WFF9 M4WIP6 M0QYS5 ENST00000597811.5 |
