MT3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	21 studies	56% ± 15%	Explore
oligodendrocyte precursor cell	14 studies	39% ± 20%	Explore
oligodendrocyte	11 studies	31% ± 18%	Explore
endothelial cell	6 studies	33% ± 12%	Explore
glutamatergic neuron	5 studies	33% ± 15%	Explore
GABAergic neuron	4 studies	28% ± 9%	Explore
microglial cell	4 studies	26% ± 12%	Explore
retinal ganglion cell	4 studies	64% ± 23%	Explore
deuterosomal cell	3 studies	20% ± 3%	Explore
neuron	3 studies	39% ± 21%	Explore
amacrine cell	3 studies	23% ± 6%	Explore
Mueller cell	3 studies	33% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	32% ± 14%	Explore
eye	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	35287.66	2641 / 2642	100%	970.90	702 / 705
adrenal gland	16%	635.25	42 / 258	43%	181.47	100 / 230
kidney	0%	0	0 / 89	34%	20.61	307 / 901
ovary	0%	0	0 / 180	10%	1.60	42 / 430
tonsil	0%	0	0 / 0	9%	1.02	4 / 45
uterus	0%	0	0 / 170	8%	3.70	39 / 459
stomach	0%	0	0 / 359	7%	1.52	21 / 286
intestine	0%	4.14	1 / 966	6%	2.03	34 / 527
eye	0%	0	0 / 0	5%	1.32	4 / 80
liver	0%	0	0 / 226	5%	1.02	19 / 406
skin	0%	0	0 / 1809	4%	0.95	21 / 472
bladder	0%	0	0 / 21	4%	1.42	21 / 504
pancreas	0%	0	0 / 328	3%	0.57	6 / 178
lung	0%	0	0 / 578	3%	0.76	29 / 1155
thymus	0%	0	0 / 653	2%	1.85	15 / 605
prostate	0%	0	0 / 245	2%	0.51	8 / 502
breast	0%	0	0 / 459	1%	0.19	15 / 1118
esophagus	0%	9.93	3 / 1445	0%	0	0 / 183
blood vessel	0%	6.34	2 / 1335	0%	0	0 / 0
heart	0%	4.35	1 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_2000296	Biological process	negative regulation of hydrogen peroxide catabolic process
GO_0034614	Biological process	cellular response to reactive oxygen species
GO_0032148	Biological process	activation of protein kinase B activity
GO_0071294	Biological process	cellular response to zinc ion
GO_0010628	Biological process	positive regulation of gene expression
GO_0071276	Biological process	cellular response to cadmium ion
GO_0010273	Biological process	detoxification of copper ion
GO_1990748	Biological process	cellular detoxification
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_2000376	Biological process	positive regulation of oxygen metabolic process
GO_0051354	Biological process	negative regulation of oxidoreductase activity
GO_0071280	Biological process	cellular response to copper ion
GO_0034599	Biological process	cellular response to oxidative stress
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0033210	Biological process	leptin-mediated signaling pathway
GO_0001666	Biological process	response to hypoxia
GO_0050821	Biological process	protein stabilization
GO_0006882	Biological process	intracellular zinc ion homeostasis
GO_0006829	Biological process	zinc ion transport
GO_0030003	Biological process	intracellular monoatomic cation homeostasis
GO_0030517	Biological process	negative regulation of axon extension
GO_0030949	Biological process	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO_0019430	Biological process	removal of superoxide radicals
GO_0032095	Biological process	regulation of response to food
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0006112	Biological process	energy reserve metabolic process
GO_0071456	Biological process	cellular response to hypoxia
GO_0030308	Biological process	negative regulation of cell growth
GO_0005615	Cellular component	extracellular space
GO_0005874	Cellular component	microtubule
GO_0043197	Cellular component	dendritic spine
GO_0005840	Cellular component	ribosome
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0097450	Cellular component	astrocyte end-foot
GO_0016234	Cellular component	inclusion body
GO_0005829	Cellular component	cytosol
GO_0008021	Cellular component	synaptic vesicle
GO_0005737	Cellular component	cytoplasm
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0030424	Cellular component	axon
GO_0005634	Cellular component	nucleus
GO_0046870	Molecular function	cadmium ion binding
GO_0030295	Molecular function	protein kinase activator activity
GO_0016209	Molecular function	antioxidant activity
GO_0008270	Molecular function	zinc ion binding
GO_0046872	Molecular function	metal ion binding
GO_0005507	Molecular function	copper ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MT3
Protein name	Metallothionein-3 (Metallothionein-III) Metallothionein-3 (MT-3) (GIFB) (GIF) (Growth inhibitory factor) (Metallothionein-III) (MT-III) Metallothionein
Synonyms
Description	FUNCTION: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro. FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals. . FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals. .
Accessions	H3BQX6 ENST00000570176.1 ENST00000200691.5 H3BPK2 ENST00000561640.5 P25713 ENST00000565838.5 H3BTG5

MT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review