I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 18 studies | 34% ± 14% | |
| myofibroblast cell | 8 studies | 32% ± 8% | |
| cardiac muscle cell | 6 studies | 47% ± 17% | |
| pericyte | 3 studies | 33% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 18 studies | 34% ± 14% | |
| myofibroblast cell | 8 studies | 32% ± 8% | |
| cardiac muscle cell | 6 studies | 47% ± 17% | |
| pericyte | 3 studies | 33% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| heart | 3 studies | 26% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 87% | 2358.34 | 213 / 245 | 89% | 5.94 | 445 / 502 |
| bladder | 100% | 7013.76 | 21 / 21 | 30% | 1.31 | 150 / 504 |
| intestine | 84% | 5886.56 | 813 / 966 | 45% | 1.56 | 237 / 527 |
| stomach | 70% | 2045.11 | 252 / 359 | 56% | 3.98 | 161 / 286 |
| esophagus | 80% | 4636.17 | 1158 / 1445 | 46% | 2.34 | 84 / 183 |
| uterus | 98% | 4373.22 | 166 / 170 | 16% | 8.83 | 73 / 459 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.13 | 1 / 1 |
| blood vessel | 100% | 8249.31 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 79% | 1628.04 | 142 / 180 | 11% | 0.41 | 49 / 430 |
| heart | 89% | 2231.02 | 764 / 861 | 0% | 0 | 0 / 0 |
| lung | 67% | 965.21 | 389 / 578 | 21% | 1.58 | 245 / 1155 |
| adipose | 48% | 845.23 | 579 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 6% | 57.56 | 5 / 89 | 31% | 0.90 | 280 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 31% | 1.78 | 9 / 29 |
| breast | 24% | 300.11 | 109 / 459 | 4% | 0.14 | 46 / 1118 |
| pancreas | 0% | 0 | 0 / 328 | 26% | 1.19 | 47 / 178 |
| thymus | 11% | 138.82 | 69 / 653 | 15% | 0.37 | 91 / 605 |
| skin | 14% | 159.32 | 253 / 1809 | 1% | 0.02 | 7 / 472 |
| adrenal gland | 1% | 12.57 | 2 / 258 | 12% | 0.28 | 27 / 230 |
| liver | 0% | 3.76 | 1 / 226 | 5% | 0.08 | 20 / 406 |
| brain | 0% | 4.55 | 9 / 2642 | 1% | 0.05 | 9 / 705 |
| muscle | 1% | 15.66 | 12 / 803 | 0% | 0 | 0 / 0 |
| spleen | 1% | 10.45 | 3 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| GO_0030511 | Biological process | positive regulation of transforming growth factor beta receptor signaling pathway |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0048286 | Biological process | lung alveolus development |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_1904706 | Biological process | negative regulation of vascular associated smooth muscle cell proliferation |
| GO_0055007 | Biological process | cardiac muscle cell differentiation |
| GO_2000727 | Biological process | positive regulation of cardiac muscle cell differentiation |
| GO_2001015 | Biological process | negative regulation of skeletal muscle cell differentiation |
| GO_0001560 | Biological process | regulation of cell growth by extracellular stimulus |
| GO_0001570 | Biological process | vasculogenesis |
| GO_1900239 | Biological process | regulation of phenotypic switching |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0051152 | Biological process | positive regulation of smooth muscle cell differentiation |
| GO_1900222 | Biological process | negative regulation of amyloid-beta clearance |
| GO_0060157 | Biological process | urinary bladder development |
| GO_0060947 | Biological process | cardiac vascular smooth muscle cell differentiation |
| GO_0003231 | Biological process | cardiac ventricle development |
| GO_0010832 | Biological process | negative regulation of myotube differentiation |
| GO_0045987 | Biological process | positive regulation of smooth muscle contraction |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0001666 | Biological process | response to hypoxia |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0051145 | Biological process | smooth muscle cell differentiation |
| GO_0010659 | Biological process | cardiac muscle cell apoptotic process |
| GO_0060065 | Biological process | uterus development |
| GO_0060379 | Biological process | cardiac muscle cell myoblast differentiation |
| GO_0035051 | Biological process | cardiocyte differentiation |
| GO_0048565 | Biological process | digestive tract development |
| GO_0060354 | Biological process | negative regulation of cell adhesion molecule production |
| GO_0097070 | Biological process | ductus arteriosus closure |
| GO_0043954 | Biological process | cellular component maintenance |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_1904753 | Biological process | negative regulation of vascular associated smooth muscle cell migration |
| GO_0010667 | Biological process | negative regulation of cardiac muscle cell apoptotic process |
| GO_0045736 | Biological process | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO_0045661 | Biological process | regulation of myoblast differentiation |
| GO_0055012 | Biological process | ventricular cardiac muscle cell differentiation |
| GO_0051150 | Biological process | regulation of smooth muscle cell differentiation |
| GO_0045815 | Biological process | transcription initiation-coupled chromatin remodeling |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_2000587 | Biological process | negative regulation of platelet-derived growth factor receptor-beta signaling pathway |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0070412 | Molecular function | R-SMAD binding |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0035035 | Molecular function | histone acetyltransferase binding |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0042826 | Molecular function | histone deacetylase binding |
| Gene name | MYOCD |
| Protein name | Myocardin |
| Synonyms | DKFZp686O15128 MYCD |
| Description | FUNCTION: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). . |
| Accessions | Q6N065 J3KSX3 ENST00000425538.6 [Q8IZQ8-3] ENST00000443061.1 Q8IZQ8 ENST00000343344.8 [Q8IZQ8-1] ENST00000579237.5 |
