Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2814.53 | 1445 / 1445 | 100% | 21.31 | 183 / 183 |
| stomach | 100% | 2243.13 | 359 / 359 | 100% | 27.02 | 286 / 286 |
| lung | 100% | 2019.70 | 578 / 578 | 100% | 25.58 | 1153 / 1155 |
| intestine | 100% | 3014.16 | 966 / 966 | 100% | 27.71 | 526 / 527 |
| breast | 100% | 2506.65 | 459 / 459 | 99% | 31.81 | 1107 / 1118 |
| skin | 100% | 2522.93 | 1809 / 1809 | 99% | 30.34 | 466 / 472 |
| prostate | 100% | 1997.86 | 245 / 245 | 98% | 25.58 | 494 / 502 |
| pancreas | 99% | 1214.82 | 326 / 328 | 99% | 23.29 | 176 / 178 |
| bladder | 100% | 2610.81 | 21 / 21 | 98% | 24.39 | 494 / 504 |
| brain | 98% | 1550.76 | 2595 / 2642 | 100% | 22.39 | 702 / 705 |
| kidney | 100% | 1982.01 | 89 / 89 | 96% | 18.86 | 868 / 901 |
| thymus | 100% | 1811.60 | 652 / 653 | 96% | 21.59 | 582 / 605 |
| uterus | 100% | 1965.78 | 170 / 170 | 96% | 21.09 | 440 / 459 |
| ovary | 100% | 1686.56 | 180 / 180 | 93% | 11.31 | 402 / 430 |
| adrenal gland | 100% | 2366.35 | 258 / 258 | 84% | 12.02 | 194 / 230 |
| liver | 86% | 832.67 | 194 / 226 | 90% | 12.64 | 366 / 406 |
| adipose | 100% | 2590.49 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2657.15 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 21.37 | 29 / 29 |
| muscle | 100% | 3336.18 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1972.34 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 22.59 | 44 / 45 |
| peripheral blood | 98% | 2047.96 | 908 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 18.72 | 78 / 80 |
| heart | 93% | 1792.56 | 800 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007040 | Biological process | lysosome organization |
| GO_0007254 | Biological process | JNK cascade |
| GO_0071364 | Biological process | cellular response to epidermal growth factor stimulus |
| GO_0010040 | Biological process | response to iron(II) ion |
| GO_0016236 | Biological process | macroautophagy |
| GO_0051301 | Biological process | cell division |
| GO_0060395 | Biological process | SMAD protein signal transduction |
| GO_0036092 | Biological process | phosphatidylinositol-3-phosphate biosynthetic process |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0000423 | Biological process | mitophagy |
| GO_0006914 | Biological process | autophagy |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0038066 | Biological process | p38MAPK cascade |
| GO_0006995 | Biological process | cellular response to nitrogen starvation |
| GO_0039521 | Biological process | suppression by virus of host autophagy |
| GO_0043652 | Biological process | engulfment of apoptotic cell |
| GO_0070301 | Biological process | cellular response to hydrogen peroxide |
| GO_0098780 | Biological process | response to mitochondrial depolarisation |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0000045 | Biological process | autophagosome assembly |
| GO_2001244 | Biological process | positive regulation of intrinsic apoptotic signaling pathway |
| GO_0010288 | Biological process | response to lead ion |
| GO_0043069 | Biological process | negative regulation of programmed cell death |
| GO_0033197 | Biological process | response to vitamin E |
| GO_0090650 | Biological process | cellular response to oxygen-glucose deprivation |
| GO_0010506 | Biological process | regulation of autophagy |
| GO_0010508 | Biological process | positive regulation of autophagy |
| GO_1902902 | Biological process | negative regulation of autophagosome assembly |
| GO_0002753 | Biological process | cytoplasmic pattern recognition receptor signaling pathway |
| GO_0032801 | Biological process | receptor catabolic process |
| GO_0032465 | Biological process | regulation of cytokinesis |
| GO_0042149 | Biological process | cellular response to glucose starvation |
| GO_2000786 | Biological process | positive regulation of autophagosome assembly |
| GO_0006622 | Biological process | protein targeting to lysosome |
| GO_0045324 | Biological process | late endosome to vacuole transport |
| GO_0062029 | Biological process | positive regulation of stress granule assembly |
| GO_1905672 | Biological process | negative regulation of lysosome organization |
| GO_0048666 | Biological process | neuron development |
| GO_1902425 | Biological process | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO_0045022 | Biological process | early endosome to late endosome transport |
| GO_0097352 | Biological process | autophagosome maturation |
| GO_0071275 | Biological process | cellular response to aluminum ion |
| GO_0007080 | Biological process | mitotic metaphase chromosome alignment |
| GO_0050435 | Biological process | amyloid-beta metabolic process |
| GO_0010613 | Biological process | positive regulation of cardiac muscle hypertrophy |
| GO_0051607 | Biological process | defense response to virus |
| GO_2000378 | Biological process | negative regulation of reactive oxygen species metabolic process |
| GO_0006968 | Biological process | cellular defense response |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0071280 | Biological process | cellular response to copper ion |
| GO_0034198 | Biological process | cellular response to amino acid starvation |
| GO_0006915 | Biological process | apoptotic process |
| GO_0016241 | Biological process | regulation of macroautophagy |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005802 | Cellular component | trans-Golgi network |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005768 | Cellular component | endosome |
| GO_0032473 | Cellular component | cytoplasmic side of mitochondrial outer membrane |
| GO_0035032 | Cellular component | phosphatidylinositol 3-kinase complex, class III |
| GO_0030425 | Cellular component | dendrite |
| GO_0016604 | Cellular component | nuclear body |
| GO_0045335 | Cellular component | phagocytic vesicle |
| GO_0034271 | Cellular component | phosphatidylinositol 3-kinase complex, class III, type I |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005776 | Cellular component | autophagosome |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0034272 | Cellular component | phosphatidylinositol 3-kinase complex, class III, type II |
| GO_0000407 | Cellular component | phagophore assembly site |
| GO_0043548 | Molecular function | phosphatidylinositol 3-kinase binding |
| GO_0051020 | Molecular function | GTPase binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0019901 | Molecular function | protein kinase binding |
| Gene name | BECN1 |
| Protein name | Beclin 1 Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] Beclin-1 |
| Synonyms | GT197 hCG_16958 |
| Description | FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. .; FUNCTION: Plays a central role in autophagy. . FUNCTION: Plays a central role in autophagy . Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 . Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis . Protects against infection by a neurovirulent strain of Sindbis virus . May play a role in antiviral host defense. .; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. . |
| Accessions | K7ES83 K7ELY9 K7EQQ7 K7EKK2 Q14457 ENST00000591085.1 K7EMA2 ENST00000589636.5 ENST00000587880.1 ENST00000589663.5 ENST00000590099.6 ENST00000590764.1 K7EL88 ENST00000361523.8 ENST00000593205.5 K7ERY0 ENST00000612631.1 ENST00000590852.1 ENST00000586589.5 A0A087WVZ2 ENST00000588276.5 K7EN35 E7EV84 K7ER46 A0A024R1X5 ENST00000438274.7 |
