FUNDC1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FUNDC1 at tissue level.

III. Associated gene sets

GO_0000422Biological processautophagy of mitochondrion
GO_0000423Biological processmitophagy
GO_0001666Biological processresponse to hypoxia
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFUNDC1
Protein nameFUN14 domain-containing protein 1
Synonyms
DescriptionFUNCTION: Integral mitochondrial outer-membrane protein that mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs) . In turn, mediates angiogenesis and neoangiogenesis through interference with intracellular Ca(2+) communication and regulation of the vascular endothelial growth factor receptor KDR/VEGFR2 expression at both mRNA and protein levels . Acts also as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality and homeostasis, by interacting with and recruiting LC3 protein family to mitochondria . Mechanistically, recruits DRP1 at ER-mitochondria contact sites leading to DRP1 oligomerization and GTPase activity to facilitate mitochondrial fission during hypoxia . Additionally, plays a role in hepatic ferroptosis by interacting directly with glutathione peroxidase/GPX4 to facilitate its recruitment into mitochondria through TOM/TIM complex where it is degraded by mitophagy . .

AccessionsQ8IVP5
ENST00000378045.5