DIO3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of DIO3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	96%	337.29	235 / 245	74%	1.86	371 / 502
uterus	100%	873.97	170 / 170	58%	9.72	266 / 459
intestine	76%	158.31	731 / 966	71%	12.43	373 / 527
bladder	100%	517.19	21 / 21	46%	4.65	230 / 504
breast	96%	255.29	442 / 459	44%	2.98	492 / 1118
pancreas	49%	71.28	162 / 328	89%	9.47	158 / 178
ovary	100%	1264.36	180 / 180	27%	0.94	114 / 430
stomach	66%	118.39	236 / 359	56%	4.44	159 / 286
lung	86%	267.75	499 / 578	33%	1.38	382 / 1155
adipose	98%	482.87	1185 / 1204	0%	0	0 / 0
thymus	85%	433.73	557 / 653	12%	0.24	70 / 605
esophagus	66%	102.78	954 / 1445	22%	1.09	41 / 183
skin	68%	205.61	1227 / 1809	8%	0.26	39 / 472
blood vessel	74%	452.43	984 / 1335	0%	0	0 / 0
brain	44%	95.61	1171 / 2642	27%	0.87	190 / 705
muscle	65%	80.70	523 / 803	0%	0	0 / 0
liver	29%	171.91	66 / 226	23%	1.46	92 / 406
spleen	39%	43.69	95 / 241	0%	0	0 / 0
adrenal gland	24%	25.71	61 / 258	10%	0.31	22 / 230
lymph node	0%	0	0 / 0	28%	4.87	8 / 29
kidney	13%	16.85	12 / 89	11%	0.41	102 / 901
eye	0%	0	0 / 0	20%	1.34	16 / 80
tonsil	0%	0	0 / 0	16%	0.58	7 / 45
heart	9%	17.37	76 / 861	0%	0	0 / 0
peripheral blood	0%	0.16	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0046549	Biological process	retinal cone cell development
GO_0042446	Biological process	hormone biosynthetic process
GO_0097474	Biological process	retinal cone cell apoptotic process
GO_0070342	Biological process	brown fat cell proliferation
GO_0001666	Biological process	response to hypoxia
GO_0042403	Biological process	thyroid hormone metabolic process
GO_0040018	Biological process	positive regulation of multicellular organism growth
GO_0042404	Biological process	thyroid hormone catabolic process
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0010008	Cellular component	endosome membrane
GO_0005886	Cellular component	plasma membrane
GO_0033798	Molecular function	thyroxine 5-deiodinase activity
GO_0004800	Molecular function	thyroxine 5'-deiodinase activity

Gene name	DIO3
Protein name	Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase) Iodothyronine deiodinase
Synonyms	TXDI3 ITDI3
Description	FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. . FUNCTION: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. .
Accessions	P55073 ENST00000700173.1 A0A8V8TPY2 ENST00000510508.5

DIO3 report