EPAS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0001525Biological processangiogenesis
GO_0030324Biological processlung development
GO_0001974Biological processblood vessel remodeling
GO_0001892Biological processembryonic placenta development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0048625Biological processmyoblast fate commitment
GO_0002027Biological processregulation of heart rate
GO_0060586Biological processmulticellular organismal-level iron ion homeostasis
GO_2000434Biological processregulation of protein neddylation
GO_0002070Biological processepithelial cell maturation
GO_0030218Biological processerythrocyte differentiation
GO_0007005Biological processmitochondrion organization
GO_0001666Biological processresponse to hypoxia
GO_0043129Biological processsurfactant homeostasis
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0042415Biological processnorepinephrine metabolic process
GO_0006979Biological processresponse to oxidative stress
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071456Biological processcellular response to hypoxia
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEPAS1
Protein nameEndothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Uncharacterized protein EPAS1
Endothelial PAS domain protein 1
SynonymsMOP2
BHLHE73
PASD2
HIF2A
DescriptionFUNCTION: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). .

AccessionsQ99814
ENST00000449347.5
Q53ST6
ENST00000263734.5
C9J9N2
Q53SM6