Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 54 studies | 66% ± 19% | |
pericyte | 40 studies | 52% ± 20% | |
fibroblast | 29 studies | 32% ± 15% | |
smooth muscle cell | 25 studies | 51% ± 18% | |
endothelial cell of artery | 17 studies | 77% ± 19% | |
capillary endothelial cell | 17 studies | 74% ± 22% | |
basal cell | 16 studies | 52% ± 21% | |
vein endothelial cell | 15 studies | 68% ± 21% | |
endothelial cell of lymphatic vessel | 14 studies | 27% ± 9% | |
endothelial cell of vascular tree | 14 studies | 61% ± 20% | |
type II pneumocyte | 11 studies | 34% ± 11% | |
type I pneumocyte | 10 studies | 33% ± 11% | |
club cell | 10 studies | 50% ± 15% | |
astrocyte | 10 studies | 29% ± 13% | |
epithelial cell | 9 studies | 39% ± 16% | |
respiratory goblet cell | 8 studies | 56% ± 11% | |
ciliated cell | 7 studies | 28% ± 14% | |
secretory cell | 6 studies | 56% ± 26% | |
connective tissue cell | 6 studies | 31% ± 16% | |
adipocyte | 6 studies | 24% ± 9% | |
retinal rod cell | 5 studies | 29% ± 9% | |
Mueller cell | 5 studies | 39% ± 17% | |
macrophage | 5 studies | 22% ± 3% | |
endothelial cell of sinusoid | 4 studies | 52% ± 19% | |
glomerular endothelial cell | 4 studies | 92% ± 2% | |
retinal pigment epithelial cell | 4 studies | 44% ± 17% | |
mesothelial cell | 4 studies | 24% ± 10% | |
hepatocyte | 4 studies | 52% ± 26% | |
oligodendrocyte precursor cell | 4 studies | 29% ± 10% | |
hillock cell | 3 studies | 36% ± 18% | |
extravillous trophoblast | 3 studies | 70% ± 15% | |
placental villous trophoblast | 3 studies | 49% ± 28% | |
myofibroblast cell | 3 studies | 38% ± 31% | |
endocardial cell | 3 studies | 41% ± 13% | |
lymphocyte | 3 studies | 24% ± 5% | |
abnormal cell | 3 studies | 24% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 151860.96 | 578 / 578 | 99% | 136.97 | 1139 / 1155 |
bladder | 100% | 22526.95 | 21 / 21 | 95% | 104.08 | 481 / 504 |
kidney | 100% | 28742.22 | 89 / 89 | 94% | 276.38 | 851 / 901 |
esophagus | 95% | 16120.31 | 1374 / 1445 | 99% | 123.48 | 181 / 183 |
breast | 100% | 56926.17 | 459 / 459 | 94% | 76.69 | 1050 / 1118 |
prostate | 98% | 22825.76 | 239 / 245 | 95% | 81.34 | 478 / 502 |
thymus | 100% | 50159.85 | 652 / 653 | 91% | 134.45 | 553 / 605 |
uterus | 98% | 26282.51 | 167 / 170 | 88% | 89.61 | 406 / 459 |
intestine | 91% | 14983.01 | 876 / 966 | 96% | 72.46 | 505 / 527 |
liver | 90% | 13116.60 | 203 / 226 | 96% | 75.21 | 390 / 406 |
skin | 91% | 15794.46 | 1655 / 1809 | 89% | 61.26 | 422 / 472 |
stomach | 82% | 11131.29 | 295 / 359 | 98% | 81.26 | 279 / 286 |
adrenal gland | 91% | 13549.63 | 234 / 258 | 88% | 125.95 | 202 / 230 |
brain | 61% | 7578.55 | 1615 / 2642 | 99% | 117.03 | 700 / 705 |
pancreas | 57% | 7283.25 | 187 / 328 | 98% | 109.43 | 175 / 178 |
ovary | 58% | 9560.64 | 105 / 180 | 65% | 30.59 | 281 / 430 |
adipose | 100% | 70634.67 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 71167.94 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 283.88 | 1 / 1 |
heart | 99% | 24695.29 | 854 / 861 | 0% | 0 | 0 / 0 |
spleen | 94% | 16524.50 | 226 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 115.65 | 42 / 45 |
eye | 0% | 0 | 0 / 0 | 85% | 44.83 | 68 / 80 |
lymph node | 0% | 0 | 0 / 0 | 55% | 28.84 | 16 / 29 |
muscle | 51% | 5657.52 | 413 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 8.03 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007601 | Biological process | visual perception |
GO_0001525 | Biological process | angiogenesis |
GO_0030324 | Biological process | lung development |
GO_0001974 | Biological process | blood vessel remodeling |
GO_0001892 | Biological process | embryonic placenta development |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0007165 | Biological process | signal transduction |
GO_0048625 | Biological process | myoblast fate commitment |
GO_0002027 | Biological process | regulation of heart rate |
GO_0060586 | Biological process | multicellular organismal-level iron ion homeostasis |
GO_2000434 | Biological process | regulation of protein neddylation |
GO_0002070 | Biological process | epithelial cell maturation |
GO_0030218 | Biological process | erythrocyte differentiation |
GO_0007005 | Biological process | mitochondrion organization |
GO_0001666 | Biological process | response to hypoxia |
GO_0043129 | Biological process | surfactant homeostasis |
GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
GO_0042789 | Biological process | mRNA transcription by RNA polymerase II |
GO_0042415 | Biological process | norepinephrine metabolic process |
GO_0006979 | Biological process | response to oxidative stress |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0071456 | Biological process | cellular response to hypoxia |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0000785 | Cellular component | chromatin |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0001223 | Molecular function | transcription coactivator binding |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0005515 | Molecular function | protein binding |
Gene name | EPAS1 |
Protein name | Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) Uncharacterized protein EPAS1 Endothelial PAS domain protein 1 |
Synonyms | MOP2 BHLHE73 PASD2 HIF2A |
Description | FUNCTION: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). . |
Accessions | Q99814 ENST00000449347.5 Q53ST6 ENST00000263734.5 C9J9N2 Q53SM6 |