ABAT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	12 studies	39% ± 17%	Explore
astrocyte	11 studies	30% ± 11%	Explore
GABAergic neuron	9 studies	45% ± 23%	Explore
glutamatergic neuron	7 studies	41% ± 23%	Explore
interneuron	6 studies	45% ± 25%	Explore
hepatocyte	5 studies	43% ± 11%	Explore
neuron	4 studies	32% ± 6%	Explore
amacrine cell	4 studies	24% ± 8%	Explore
epithelial cell	4 studies	31% ± 15%	Explore
oligodendrocyte	4 studies	23% ± 5%	Explore
epithelial cell of proximal tubule	3 studies	16% ± 1%	Explore
GABAergic interneuron	3 studies	32% ± 4%	Explore
microglial cell	3 studies	25% ± 2%	Explore
neural progenitor cell	3 studies	21% ± 5%	Explore
ependymal cell	3 studies	45% ± 14%	Explore
macrophage	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	32% ± 17%	Explore
liver	3 studies	26% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	18051.16	2640 / 2642	99%	171.96	699 / 705
liver	100%	26816.25	226 / 226	90%	68.51	364 / 406
thymus	93%	4363.75	607 / 653	84%	35.47	508 / 605
prostate	73%	2442.62	180 / 245	95%	38.44	479 / 502
adrenal gland	70%	2372.83	180 / 258	86%	64.04	198 / 230
pancreas	97%	6048.79	318 / 328	47%	10.00	84 / 178
kidney	88%	6028.08	78 / 89	42%	10.00	380 / 901
ureter	0%	0	0 / 0	100%	11.76	1 / 1
breast	25%	573.26	115 / 459	66%	25.81	734 / 1118
bladder	48%	1431.05	10 / 21	41%	7.43	206 / 504
ovary	59%	1690.13	107 / 180	24%	4.35	104 / 430
intestine	36%	860.10	350 / 966	37%	6.07	197 / 527
stomach	19%	441.06	70 / 359	44%	7.71	127 / 286
esophagus	36%	860.19	516 / 1445	20%	3.02	36 / 183
lung	15%	302.60	86 / 578	18%	2.86	210 / 1155
heart	30%	845.01	258 / 861	0%	0	0 / 0
blood vessel	28%	659.03	374 / 1335	0%	0	0 / 0
uterus	12%	285.58	21 / 170	15%	2.60	71 / 459
lymph node	0%	0	0 / 0	17%	1.74	5 / 29
tonsil	0%	0	0 / 0	16%	1.53	7 / 45
skin	8%	176.81	153 / 1809	7%	0.91	32 / 472
peripheral blood	14%	312.58	129 / 929	0%	0	0 / 0
spleen	7%	167.68	17 / 241	0%	0	0 / 0
adipose	6%	132.20	76 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.68	4 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010039	Biological process	response to iron ion
GO_0009450	Biological process	gamma-aminobutyric acid catabolic process
GO_0033602	Biological process	negative regulation of dopamine secretion
GO_0035640	Biological process	exploration behavior
GO_0031652	Biological process	positive regulation of heat generation
GO_0045471	Biological process	response to ethanol
GO_0032024	Biological process	positive regulation of insulin secretion
GO_1904450	Biological process	positive regulation of aspartate secretion
GO_0045776	Biological process	negative regulation of blood pressure
GO_0009448	Biological process	gamma-aminobutyric acid metabolic process
GO_0097151	Biological process	positive regulation of inhibitory postsynaptic potential
GO_0001666	Biological process	response to hypoxia
GO_0070474	Biological process	positive regulation of uterine smooth muscle contraction
GO_1902722	Biological process	positive regulation of prolactin secretion
GO_0035094	Biological process	response to nicotine
GO_0007620	Biological process	copulation
GO_0021549	Biological process	cerebellum development
GO_0045964	Biological process	positive regulation of dopamine metabolic process
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0048148	Biological process	behavioral response to cocaine
GO_0007626	Biological process	locomotory behavior
GO_0009449	Biological process	gamma-aminobutyric acid biosynthetic process
GO_0014053	Biological process	negative regulation of gamma-aminobutyric acid secretion
GO_0005739	Cellular component	mitochondrion
GO_0005759	Cellular component	mitochondrial matrix
GO_0032144	Cellular component	4-aminobutyrate transaminase complex
GO_0032145	Molecular function	succinate-semialdehyde dehydrogenase binding
GO_0047298	Molecular function	(S)-3-amino-2-methylpropionate transaminase activity
GO_0051536	Molecular function	iron-sulfur cluster binding
GO_0030170	Molecular function	pyridoxal phosphate binding
GO_0003867	Molecular function	4-aminobutyrate transaminase activity
GO_0042802	Molecular function	identical protein binding
GO_0034386	Molecular function	4-aminobutyrate:2-oxoglutarate transaminase activity
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	ABAT
Protein name	4-aminobutyrate aminotransferase isoform B 4-aminobutyrate aminotransferase 4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT) 4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) (EC 2.6.1.22) ((S)-3-amino-2-methylpropionate transaminase) (GABA aminotransferase) (Gamma-amino-N-butyrate transaminase) (L-AIBAT)
Synonyms	GABAT
Description	FUNCTION: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively . Can also convert delta-aminovalerate and beta-alanine (By similarity). .
Accessions	ENST00000565016.5 H3BP74 H3BP84 ENST00000569156.5 X5D8S1 ENST00000562115.1 H3BNQ7 ENST00000425191.6 X5D2Y3 ENST00000564714.5 ENST00000567812.5 P80404 H3BRT1 H3BMJ9 H3BRN4 ENST00000396600.6 H3BRJ1 ENST00000568847.5 ENST00000268251.13 ENST00000561870.5 H3BPW8 ENST00000566590.5

ABAT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review