MMP14 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	33 studies	30% ± 15%	Explore
macrophage	12 studies	26% ± 10%	Explore
connective tissue cell	8 studies	37% ± 12%	Explore
pericyte	6 studies	29% ± 8%	Explore
endothelial cell	5 studies	23% ± 9%	Explore
myofibroblast cell	5 studies	30% ± 8%	Explore
myeloid cell	5 studies	26% ± 8%	Explore
epithelial cell	5 studies	26% ± 8%	Explore
smooth muscle cell	4 studies	22% ± 9%	Explore
adventitial cell	4 studies	20% ± 4%	Explore
basal cell	4 studies	21% ± 5%	Explore
secretory cell	3 studies	18% ± 2%	Explore
monocyte	3 studies	20% ± 5%	Explore
ciliated cell	3 studies	19% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	22% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	32327.22	1809 / 1809	100%	770.56	471 / 472
esophagus	100%	14398.02	1444 / 1445	97%	274.05	178 / 183
uterus	100%	25724.46	170 / 170	97%	438.49	443 / 459
bladder	100%	18933.43	21 / 21	96%	357.01	486 / 504
breast	100%	19746.17	459 / 459	96%	391.29	1072 / 1118
lung	100%	17179.01	577 / 578	95%	305.46	1098 / 1155
intestine	100%	13665.31	965 / 966	94%	240.63	493 / 527
stomach	94%	8803.77	337 / 359	94%	225.69	270 / 286
thymus	100%	9978.95	650 / 653	80%	137.12	485 / 605
ovary	100%	16203.49	180 / 180	73%	153.09	316 / 430
kidney	84%	5811.58	75 / 89	87%	205.35	782 / 901
pancreas	64%	3220.32	209 / 328	96%	563.54	171 / 178
prostate	100%	11606.40	245 / 245	48%	47.78	242 / 502
adrenal gland	86%	5453.92	222 / 258	24%	50.07	56 / 230
adipose	100%	23796.76	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	428.51	80 / 80
ureter	0%	0	0 / 0	100%	64.02	1 / 1
blood vessel	100%	20131.27	1334 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	368.17	44 / 45
spleen	94%	5573.86	227 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	69%	160.05	20 / 29
heart	61%	3476.07	526 / 861	0%	0	0 / 0
brain	2%	70.34	42 / 2642	42%	83.58	299 / 705
liver	7%	321.81	16 / 226	33%	71.79	132 / 406
muscle	21%	995.50	169 / 803	0%	0	0 / 0
peripheral blood	0%	21.72	4 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043615	Biological process	astrocyte cell migration
GO_0048870	Biological process	cell motility
GO_0001525	Biological process	angiogenesis
GO_1905523	Biological process	positive regulation of macrophage migration
GO_1990834	Biological process	response to odorant
GO_0030324	Biological process	lung development
GO_0060322	Biological process	head development
GO_0043627	Biological process	response to estrogen
GO_0030307	Biological process	positive regulation of cell growth
GO_0048754	Biological process	branching morphogenesis of an epithelial tube
GO_0160145	Biological process	negative regulation of GDF15-GFRAL signaling pathway
GO_0001541	Biological process	ovarian follicle development
GO_0035988	Biological process	chondrocyte proliferation
GO_0035987	Biological process	endodermal cell differentiation
GO_0016485	Biological process	protein processing
GO_0014070	Biological process	response to organic cyclic compound
GO_0030198	Biological process	extracellular matrix organization
GO_0022617	Biological process	extracellular matrix disassembly
GO_0051895	Biological process	negative regulation of focal adhesion assembly
GO_0001958	Biological process	endochondral ossification
GO_0045579	Biological process	positive regulation of B cell differentiation
GO_0030574	Biological process	collagen catabolic process
GO_0010831	Biological process	positive regulation of myotube differentiation
GO_0031638	Biological process	zymogen activation
GO_0048771	Biological process	tissue remodeling
GO_0030335	Biological process	positive regulation of cell migration
GO_0001666	Biological process	response to hypoxia
GO_0001935	Biological process	endothelial cell proliferation
GO_0006508	Biological process	proteolysis
GO_0010954	Biological process	positive regulation of protein processing
GO_0030163	Biological process	protein catabolic process
GO_0048701	Biological process	embryonic cranial skeleton morphogenesis
GO_0008584	Biological process	male gonad development
GO_0001501	Biological process	skeletal system development
GO_0097094	Biological process	craniofacial suture morphogenesis
GO_0009612	Biological process	response to mechanical stimulus
GO_1903076	Biological process	regulation of protein localization to plasma membrane
GO_0045746	Biological process	negative regulation of Notch signaling pathway
GO_0006979	Biological process	response to oxidative stress
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0044354	Cellular component	macropinosome
GO_0005796	Cellular component	Golgi lumen
GO_0031012	Cellular component	extracellular matrix
GO_0005925	Cellular component	focal adhesion
GO_0045111	Cellular component	intermediate filament cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0042470	Cellular component	melanosome
GO_0005634	Cellular component	nucleus
GO_0004175	Molecular function	endopeptidase activity
GO_0070006	Molecular function	metalloaminopeptidase activity
GO_0005178	Molecular function	integrin binding
GO_0008270	Molecular function	zinc ion binding
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity

IV. Literature review

[source]

Gene name	MMP14
Protein name	Matrix metallopeptidase 14 Matrix metalloproteinase-14 (EC 3.4.24.80) Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Synonyms
Description	FUNCTION: Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 . Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 . Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis . .
Accessions	ENST00000547279.1 ENST00000680097.1 ENST00000311852.11 A0A7P0TAG0 F8VP90 ENST00000680941.1 A0A7P0TAV6 ENST00000548162.2 A0A7P0TBK8 P50281 K4RH61

MMP14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review