WTIP report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WTIP at tissue level.

III. Associated gene sets

GO_0022604Biological processregulation of cell morphogenesis
GO_0035195Biological processmiRNA-mediated post-transcriptional gene silencing
GO_0007010Biological processcytoskeleton organization
GO_0001666Biological processresponse to hypoxia
GO_0030030Biological processcell projection organization
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0035331Biological processnegative regulation of hippo signaling
GO_0000932Cellular componentP-body
GO_0005912Cellular componentadherens junction
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameWTIP
Protein nameWT1 interacting protein
Wilms tumor protein 1-interacting protein (WT1-interacting protein)
Synonyms
DescriptionFUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). .

AccessionsENST00000585928.1
K7EKM1
ENST00000590071.7
A6NIX2