TH report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TH at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TH at tissue level.

III. Associated gene sets

GO_0009651Biological processresponse to salt stress
GO_0014823Biological processresponse to activity
GO_0042416Biological processdopamine biosynthetic process
GO_0042462Biological processeye photoreceptor cell development
GO_0052314Biological processphytoalexin metabolic process
GO_0001666Biological processresponse to hypoxia
GO_0042755Biological processeating behavior
GO_0010043Biological processresponse to zinc ion
GO_0001963Biological processsynaptic transmission, dopaminergic
GO_0007613Biological processmemory
GO_0035176Biological processsocial behavior
GO_0016137Biological processglycoside metabolic process
GO_0007626Biological processlocomotory behavior
GO_0015842Biological processaminergic neurotransmitter loading into synaptic vesicle
GO_0071333Biological processcellular response to glucose stimulus
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0033076Biological processisoquinoline alkaloid metabolic process
GO_0043434Biological processresponse to peptide hormone
GO_0048596Biological processembryonic camera-type eye morphogenesis
GO_0007612Biological processlearning
GO_0006631Biological processfatty acid metabolic process
GO_0071287Biological processcellular response to manganese ion
GO_0006665Biological processsphingolipid metabolic process
GO_0043473Biological processpigmentation
GO_0009653Biological processanatomical structure morphogenesis
GO_0007617Biological processmating behavior
GO_0051412Biological processresponse to corticosterone
GO_0008016Biological processregulation of heart contraction
GO_1990384Biological processhyaloid vascular plexus regression
GO_0003007Biological processheart morphogenesis
GO_0007601Biological processvisual perception
GO_0032355Biological processresponse to estradiol
GO_0009887Biological processanimal organ morphogenesis
GO_0035902Biological processresponse to immobilization stress
GO_0035900Biological processresponse to isolation stress
GO_0045471Biological processresponse to ethanol
GO_0071363Biological processcellular response to growth factor stimulus
GO_0042418Biological processepinephrine biosynthetic process
GO_0071312Biological processcellular response to alkaloid
GO_0006585Biological processdopamine biosynthetic process from tyrosine
GO_0042214Biological processterpene metabolic process
GO_0018963Biological processphthalate metabolic process
GO_0009416Biological processresponse to light stimulus
GO_0001975Biological processresponse to amphetamine
GO_0045472Biological processresponse to ether
GO_0007507Biological processheart development
GO_0051602Biological processresponse to electrical stimulus
GO_0042421Biological processnorepinephrine biosynthetic process
GO_0031667Biological processresponse to nutrient levels
GO_0046684Biological processresponse to pyrethroid
GO_0009635Biological processresponse to herbicide
GO_0042745Biological processcircadian sleep/wake cycle
GO_0071316Biological processcellular response to nicotine
GO_0021987Biological processcerebral cortex development
GO_0032496Biological processresponse to lipopolysaccharide
GO_0043195Cellular componentterminal bouton
GO_0043005Cellular componentneuron projection
GO_0033162Cellular componentmelanosome membrane
GO_0008021Cellular componentsynaptic vesicle
GO_0005634Cellular componentnucleus
GO_0030425Cellular componentdendrite
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005739Cellular componentmitochondrion
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005790Cellular componentsmooth endoplasmic reticulum
GO_0043204Cellular componentperikaryon
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0008198Molecular functionferrous iron binding
GO_0004511Molecular functiontyrosine 3-monooxygenase activity
GO_0035240Molecular functiondopamine binding
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0019825Molecular functionoxygen binding
GO_0008199Molecular functionferric iron binding
GO_0005515Molecular functionprotein binding
GO_0034617Molecular functiontetrahydrobiopterin binding
GO_0016597Molecular functionamino acid binding

IV. Literature review

[source]
Gene nameTH
Protein nameTyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)
Tyrosine hydroxylase
Tyrosine hydroxylase (EC 1.14.16.2)
TH protein
SynonymsTYH
DescriptionFUNCTION: Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa . In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). .; FUNCTION: [Isoform 5]: Lacks catalytic activity. .; FUNCTION: [Isoform 6]: Lacks catalytic activity. .

AccessionsENST00000416223.5
ENST00000333684.9 [P07101-6]
Q7KZ39
ENST00000381175.5 [P07101-2]
ENST00000412076.1
Q7KZ36
E7EQI0
Q7KZ44
H0Y677
P78428
H0Y670
Q7KZ38
P07101
ENST00000381178.5 [P07101-1]
F8W8M5
Q9UQ57
ENST00000352909.8 [P07101-3]
ENST00000324155.8
ENST00000381168.7