Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1953.26 | 1445 / 1445 | 100% | 25.48 | 183 / 183 |
| ovary | 100% | 2107.14 | 180 / 180 | 100% | 29.25 | 430 / 430 |
| lung | 100% | 1711.84 | 577 / 578 | 100% | 17.36 | 1151 / 1155 |
| breast | 100% | 1886.82 | 459 / 459 | 99% | 24.99 | 1112 / 1118 |
| prostate | 100% | 2083.50 | 245 / 245 | 99% | 17.18 | 497 / 502 |
| thymus | 100% | 2232.32 | 653 / 653 | 99% | 19.84 | 597 / 605 |
| uterus | 100% | 2032.52 | 170 / 170 | 97% | 15.25 | 447 / 459 |
| bladder | 100% | 2005.10 | 21 / 21 | 97% | 14.66 | 490 / 504 |
| stomach | 100% | 1421.74 | 359 / 359 | 97% | 16.91 | 278 / 286 |
| intestine | 100% | 1980.46 | 966 / 966 | 97% | 14.31 | 509 / 527 |
| kidney | 100% | 1647.27 | 89 / 89 | 95% | 14.61 | 858 / 901 |
| pancreas | 100% | 1211.89 | 327 / 328 | 94% | 13.81 | 168 / 178 |
| skin | 100% | 2447.33 | 1809 / 1809 | 90% | 13.11 | 424 / 472 |
| liver | 100% | 1086.98 | 226 / 226 | 74% | 6.23 | 301 / 406 |
| brain | 75% | 481.07 | 1981 / 2642 | 82% | 8.16 | 576 / 705 |
| adrenal gland | 100% | 1784.15 | 258 / 258 | 39% | 4.29 | 89 / 230 |
| adipose | 100% | 1885.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1834.74 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 15.43 | 29 / 29 |
| spleen | 100% | 1943.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.30 | 1 / 1 |
| muscle | 99% | 1060.96 | 798 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 1278.10 | 850 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 15.84 | 44 / 45 |
| peripheral blood | 88% | 1286.54 | 822 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 51% | 4.43 | 41 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002244 | Biological process | hematopoietic progenitor cell differentiation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0071466 | Biological process | cellular response to xenobiotic stimulus |
| GO_0097150 | Biological process | neuronal stem cell population maintenance |
| GO_0002931 | Biological process | response to ischemia |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0045667 | Biological process | regulation of osteoblast differentiation |
| GO_0043922 | Biological process | negative regulation by host of viral transcription |
| GO_1902894 | Biological process | negative regulation of miRNA transcription |
| GO_2000798 | Biological process | negative regulation of amniotic stem cell differentiation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0000381 | Biological process | regulation of alternative mRNA splicing, via spliceosome |
| GO_0046676 | Biological process | negative regulation of insulin secretion |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0043280 | Biological process | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO_2000706 | Biological process | negative regulation of dense core granule biogenesis |
| GO_0032348 | Biological process | negative regulation of aldosterone biosynthetic process |
| GO_1902459 | Biological process | positive regulation of stem cell population maintenance |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0045955 | Biological process | negative regulation of calcium ion-dependent exocytosis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0043068 | Biological process | positive regulation of programmed cell death |
| GO_2000065 | Biological process | negative regulation of cortisol biosynthetic process |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0060379 | Biological process | cardiac muscle cell myoblast differentiation |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_2000740 | Biological process | negative regulation of mesenchymal stem cell differentiation |
| GO_0071257 | Biological process | cellular response to electrical stimulus |
| GO_0071385 | Biological process | cellular response to glucocorticoid stimulus |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0050877 | Biological process | nervous system process |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0099563 | Biological process | modification of synaptic structure |
| GO_0050768 | Biological process | negative regulation of neurogenesis |
| GO_0035019 | Biological process | somatic stem cell population maintenance |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0017053 | Cellular component | transcription repressor complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0000979 | Molecular function | RNA polymerase II core promoter sequence-specific DNA binding |
| Gene name | REST |
| Protein name | RE1-silencing transcription factor variant E1c/E2g/E3/E4 RE1 silencing transcription factor (RE1-silencing transcription factor, isoform CRA_a) RE1 silencing transcription factor (RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i) RE1-silencing transcription factor variant E1a/E2f/E4e RE1-silencing transcription factor variant E1a/E2a/E2k (RE1-silencing transcription factor variant E1b/E2a/E2k) (RE1-silencing transcription factor variant E1c/E2a/E2k) RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i RE1-silencing transcription factor variant E1a/E2d/E4g RE1 silencing transcription factor RE1-silencing transcription factor variant E1a/E2/E3/E4c RE1-silencing transcription factor variant E1a/E2/E4 RE1 silencing transcription factor (RE1-silencing transcription factor variant E1a/E2l/E2i/E3/E4j) RE1 silencing transcription factor (RE1-silencing transcription factor variant E1a/E2/E3/E5) (RE1-silencing transcription factor variant E1b/E2/E3/E5) (RE1-silencing transcription factor variant E1c/E2/E3/E5) RE1 silencing transcription factor (RE1-silencing transcription factor variant E1a/E2/E5) RE1-silencing transcription factor variant E1a/E2e/E4h (RE1-silencing transcription factor variant E1b/E2e/E4h) REST protein RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4 (RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4) RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4 |
| Synonyms | hCG_1746842 NRSF XBR |
| Description | FUNCTION: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells . Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes . Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression . Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes . Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons . Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions . May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response . Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines . .; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 . May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes . However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity . Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). . |
| Accessions | ENST00000675105.1 [Q13127-1] L0B1U9 A0A6Q8PH19 L0B1R5 L0B3N3 L0B1S6 ENST00000514063.2 ENST00000675341.1 L0B2V9 ENST00000622863.4 L0B1R1 A0A087X1C2 L0B2U7 ENST00000611211.2 A0PJ83 L0B1V4 ENST00000619101.5 ENST00000640168.2 A0A1W2PQA1 L0B3Z9 ENST00000638187.2 ENST00000640343.2 ENST00000616975.5 L0B2V3 ENST00000309042.12 [Q13127-1] L0B3Z2 L0B3Y5 L0B1U4 Q13127 L0B3M6 |
