HMOX2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	28 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	23 studies	26% ± 9%	Explore
CD4-positive, alpha-beta T cell	22 studies	25% ± 7%	Explore
T cell	14 studies	20% ± 4%	Explore
regulatory T cell	14 studies	24% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	32% ± 11%	Explore
mature NK T cell	12 studies	26% ± 9%	Explore
gamma-delta T cell	11 studies	29% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	24% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	26% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	27% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	29% ± 6%	Explore
endothelial cell	9 studies	22% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	26% ± 10%	Explore
endothelial cell of artery	8 studies	21% ± 5%	Explore
mucosal invariant T cell	8 studies	22% ± 5%	Explore
pericyte	8 studies	21% ± 4%	Explore
epithelial cell	7 studies	34% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 5%	Explore
T follicular helper cell	6 studies	22% ± 3%	Explore
exhausted T cell	5 studies	34% ± 9%	Explore
fibroblast	5 studies	21% ± 8%	Explore
endothelial cell of lymphatic vessel	5 studies	26% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	34% ± 8%	Explore
neuron	4 studies	28% ± 12%	Explore
retinal ganglion cell	4 studies	61% ± 27%	Explore
smooth muscle cell	4 studies	20% ± 5%	Explore
lymphocyte	4 studies	20% ± 5%	Explore
cardiac muscle cell	4 studies	17% ± 2%	Explore
ciliated cell	4 studies	28% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	42% ± 6%	Explore
innate lymphoid cell	4 studies	21% ± 6%	Explore
macrophage	4 studies	21% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	33% ± 6%	Explore
T-helper 17 cell	4 studies	24% ± 8%	Explore
plasma cell	3 studies	26% ± 15%	Explore
plasmablast	3 studies	45% ± 15%	Explore
pancreatic A cell	3 studies	22% ± 2%	Explore
conventional dendritic cell	3 studies	30% ± 11%	Explore
non-classical monocyte	3 studies	22% ± 5%	Explore
epithelial cell of proximal tubule	3 studies	18% ± 2%	Explore
connective tissue cell	3 studies	27% ± 9%	Explore
B cell	3 studies	19% ± 3%	Explore
basal cell	3 studies	32% ± 8%	Explore
retina horizontal cell	3 studies	25% ± 9%	Explore
intraepithelial lymphocyte	3 studies	25% ± 5%	Explore
dendritic cell	3 studies	34% ± 2%	Explore
oligodendrocyte	3 studies	27% ± 6%	Explore
T-helper 1 cell	3 studies	27% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	27% ± 5%	Explore
double negative thymocyte	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	22% ± 2%	Explore
lung	6 studies	22% ± 7%	Explore
liver	4 studies	19% ± 1%	Explore
pancreas	3 studies	21% ± 2%	Explore
kidney	3 studies	21% ± 1%	Explore
eye	3 studies	19% ± 6%	Explore
lymph node	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	3663.12	89 / 89	100%	51.02	901 / 901
liver	100%	3353.42	226 / 226	100%	49.17	406 / 406
ovary	100%	1380.76	180 / 180	100%	29.60	430 / 430
skin	100%	2433.06	1809 / 1809	100%	66.73	472 / 472
stomach	100%	4144.36	359 / 359	100%	49.14	286 / 286
uterus	100%	1868.82	170 / 170	100%	57.37	459 / 459
esophagus	100%	2687.29	1444 / 1445	100%	40.76	183 / 183
brain	100%	3857.74	2638 / 2642	100%	68.43	705 / 705
lung	100%	2615.95	577 / 578	100%	50.29	1154 / 1155
thymus	100%	2499.30	652 / 653	100%	50.56	604 / 605
breast	100%	3095.04	459 / 459	100%	59.36	1114 / 1118
intestine	100%	2140.59	966 / 966	100%	58.92	525 / 527
bladder	100%	1914.24	21 / 21	99%	54.09	500 / 504
prostate	100%	2042.87	244 / 245	100%	56.36	500 / 502
adrenal gland	100%	2804.05	258 / 258	99%	44.11	227 / 230
pancreas	98%	1272.48	321 / 328	100%	55.29	178 / 178
adipose	100%	3415.99	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	57.12	80 / 80
lymph node	0%	0	0 / 0	100%	65.48	29 / 29
spleen	100%	3665.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	59.69	45 / 45
ureter	0%	0	0 / 0	100%	69.52	1 / 1
blood vessel	99%	1706.05	1327 / 1335	0%	0	0 / 0
heart	98%	4447.41	845 / 861	0%	0	0 / 0
peripheral blood	95%	1931.40	878 / 929	0%	0	0 / 0
muscle	94%	1151.66	757 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006979	Biological process	response to oxidative stress
GO_0001666	Biological process	response to hypoxia
GO_0006788	Biological process	heme oxidation
GO_0042167	Biological process	heme catabolic process
GO_0005886	Cellular component	plasma membrane
GO_0035579	Cellular component	specific granule membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0004392	Molecular function	heme oxygenase (decyclizing) activity
GO_0020037	Molecular function	heme binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	HMOX2
Protein name	Heme oxygenase 2 Heme oxygenase (EC 1.14.14.18) heme oxygenase (biliverdin-producing) (EC 1.14.14.18) Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form]
Synonyms	HO2
Description	FUNCTION: [Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. .; FUNCTION: [Heme oxygenase 2 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. .
Accessions	ENST00000570646.6 [P30519-1] ENST00000615778.4 [P30519-1] ENST00000574466.5 ENST00000632175.1 A0A1B0GXH0 ENST00000619913.4 [P30519-1] ENST00000631677.1 [P30519-1] ENST00000414777.5 [P30519-1] I3L1Y2 I3L159 ENST00000575129.5 ENST00000631495.1 ENST00000398595.7 [P30519-1] ENST00000619528.4 [P30519-1] ENST00000575051.5 P30519 I3L276 ENST00000634141.1 I3L463 ENST00000633319.1 [P30519-2] A0A087WT44 I3L1F5 ENST00000570445.5 ENST00000633529.1 ENST00000622146.4 [P30519-1] ENST00000570622.1 ENST00000219700.10 [P30519-1] ENST00000575120.5 [P30519-2] ENST00000621065.4 [P30519-1] ENST00000632458.1 [P30519-1] ENST00000458134.7 [P30519-1] ENST00000631540.1 [P30519-1] ENST00000406590.6 [P30519-1] ENST00000576827.5 ENST00000631986.1 ENST00000633088.1 ENST00000612525.4 [P30519-1] ENST00000613539.1 Q6IBP2 ENST00000572812.5 ENST00000631697.1 Q6FHB5 I3L4P8 ENST00000617111.2 ENST00000620445.3 [P30519-1]

HMOX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review