I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 9 studies | 26% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 9 studies | 26% ± 12% |
Insufficient scRNA-seq data for expression of VEGFD at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 4066.24 | 578 / 578 | 60% | 4.76 | 694 / 1155 |
| adrenal gland | 80% | 916.09 | 206 / 258 | 72% | 5.31 | 165 / 230 |
| breast | 99% | 1541.65 | 453 / 459 | 36% | 1.68 | 408 / 1118 |
| bladder | 95% | 599.48 | 20 / 21 | 27% | 1.06 | 137 / 504 |
| uterus | 86% | 671.54 | 147 / 170 | 27% | 1.42 | 126 / 459 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.10 | 1 / 1 |
| muscle | 100% | 1045.59 | 801 / 803 | 0% | 0 | 0 / 0 |
| esophagus | 70% | 586.67 | 1015 / 1445 | 26% | 0.64 | 48 / 183 |
| adipose | 95% | 840.72 | 1139 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 73% | 448.08 | 261 / 359 | 17% | 1.41 | 48 / 286 |
| intestine | 72% | 428.08 | 700 / 966 | 8% | 1.80 | 42 / 527 |
| heart | 79% | 458.52 | 682 / 861 | 0% | 0 | 0 / 0 |
| kidney | 38% | 132.76 | 34 / 89 | 40% | 1.00 | 358 / 901 |
| ovary | 74% | 360.76 | 133 / 180 | 3% | 0.99 | 13 / 430 |
| skin | 23% | 54.99 | 422 / 1809 | 51% | 1.95 | 242 / 472 |
| blood vessel | 69% | 227.49 | 927 / 1335 | 0% | 0 | 0 / 0 |
| brain | 50% | 96.69 | 1320 / 2642 | 15% | 0.23 | 105 / 705 |
| thymus | 52% | 139.68 | 339 / 653 | 8% | 0.52 | 48 / 605 |
| liver | 12% | 22.18 | 26 / 226 | 46% | 6.10 | 186 / 406 |
| spleen | 56% | 148.52 | 134 / 241 | 0% | 0 | 0 / 0 |
| prostate | 42% | 124.36 | 103 / 245 | 9% | 0.13 | 46 / 502 |
| eye | 0% | 0 | 0 / 0 | 36% | 0.71 | 29 / 80 |
| pancreas | 7% | 12.45 | 22 / 328 | 26% | 0.83 | 47 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 0.29 | 8 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.34 | 5 / 29 |
| peripheral blood | 0% | 0.80 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0051781 | Biological process | positive regulation of cell division |
| GO_0060754 | Biological process | positive regulation of mast cell chemotaxis |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0050918 | Biological process | positive chemotaxis |
| GO_0009617 | Biological process | response to bacterium |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0071542 | Biological process | dopaminergic neuron differentiation |
| GO_0038084 | Biological process | vascular endothelial growth factor signaling pathway |
| GO_0002040 | Biological process | sprouting angiogenesis |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0048144 | Biological process | fibroblast proliferation |
| GO_0048010 | Biological process | vascular endothelial growth factor receptor signaling pathway |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0050930 | Biological process | induction of positive chemotaxis |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0016020 | Cellular component | membrane |
| GO_0031093 | Cellular component | platelet alpha granule lumen |
| GO_0005161 | Molecular function | platelet-derived growth factor receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0042056 | Molecular function | chemoattractant activity |
| GO_0043185 | Molecular function | vascular endothelial growth factor receptor 3 binding |
| GO_0005172 | Molecular function | vascular endothelial growth factor receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | VEGFD |
| Protein name | Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF) |
| Synonyms | FIGF |
| Description | FUNCTION: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. . |
| Accessions | O43915 ENST00000297904.4 |
