HIF1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002052Biological processpositive regulation of neuroblast proliferation
GO_0002071Biological processglandular epithelial cell maturation
GO_0032722Biological processpositive regulation of chemokine production
GO_0010468Biological processregulation of gene expression
GO_0006089Biological processlactate metabolic process
GO_0046716Biological processmuscle cell cellular homeostasis
GO_1903377Biological processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0042541Biological processhemoglobin biosynthetic process
GO_0001922Biological processB-1 B cell homeostasis
GO_0001947Biological processheart looping
GO_0002062Biological processchondrocyte differentiation
GO_0097152Biological processmesenchymal cell apoptotic process
GO_0061030Biological processepithelial cell differentiation involved in mammary gland alveolus development
GO_2000434Biological processregulation of protein neddylation
GO_0051402Biological processneuron apoptotic process
GO_0001666Biological processresponse to hypoxia
GO_1902895Biological processpositive regulation of miRNA transcription
GO_1901526Biological processpositive regulation of mitophagy
GO_0045926Biological processnegative regulation of growth
GO_0032909Biological processregulation of transforming growth factor beta2 production
GO_0070244Biological processnegative regulation of thymocyte apoptotic process
GO_0010573Biological processvascular endothelial growth factor production
GO_0001525Biological processangiogenesis
GO_0010039Biological processresponse to iron ion
GO_0003151Biological processoutflow tract morphogenesis
GO_0046886Biological processpositive regulation of hormone biosynthetic process
GO_0070101Biological processpositive regulation of chemokine-mediated signaling pathway
GO_0097411Biological processhypoxia-inducible factor-1alpha signaling pathway
GO_0001755Biological processneural crest cell migration
GO_0010629Biological processnegative regulation of gene expression
GO_0001892Biological processembryonic placenta development
GO_0045766Biological processpositive regulation of angiogenesis
GO_2000273Biological processpositive regulation of signaling receptor activity
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0010628Biological processpositive regulation of gene expression
GO_0032007Biological processnegative regulation of TOR signaling
GO_0071347Biological processcellular response to interleukin-1
GO_0006110Biological processregulation of glycolytic process
GO_0008542Biological processvisual learning
GO_0003208Biological processcardiac ventricle morphogenesis
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0006879Biological processintracellular iron ion homeostasis
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045648Biological processpositive regulation of erythrocyte differentiation
GO_0000302Biological processresponse to reactive oxygen species
GO_0061072Biological processiris morphogenesis
GO_0030949Biological processpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO_0060574Biological processintestinal epithelial cell maturation
GO_0019896Biological processaxonal transport of mitochondrion
GO_0048546Biological processdigestive tract morphogenesis
GO_0032963Biological processcollagen metabolic process
GO_0007405Biological processneuroblast proliferation
GO_0035162Biological processembryonic hemopoiesis
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0002248Biological processconnective tissue replacement involved in inflammatory response wound healing
GO_0001678Biological processintracellular glucose homeostasis
GO_0061298Biological processretina vasculature development in camera-type eye
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0034599Biological processcellular response to oxidative stress
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030502Biological processnegative regulation of bone mineralization
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0051541Biological processelastin metabolic process
GO_2001054Biological processnegative regulation of mesenchymal cell apoptotic process
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001837Biological processepithelial to mesenchymal transition
GO_0031929Biological processTOR signaling
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0071542Biological processdopaminergic neuron differentiation
GO_0014850Biological processresponse to muscle activity
GO_0035773Biological processinsulin secretion involved in cellular response to glucose stimulus
GO_0098586Biological processcellular response to virus
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0030282Biological processbone mineralization
GO_1903715Biological processregulation of aerobic respiration
GO_0032364Biological processintracellular oxygen homeostasis
GO_0021987Biological processcerebral cortex development
GO_0007595Biological processlactation
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_0021502Biological processneural fold elevation formation
GO_0071456Biological processcellular response to hypoxia
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0031514Cellular componentmotile cilium
GO_0000791Cellular componenteuchromatin
GO_0032991Cellular componentprotein-containing complex
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_1904115Cellular componentaxon cytoplasm
GO_0016607Cellular componentnuclear speck
GO_0005829Cellular componentcytosol
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0051879Molecular functionHsp90 protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0070888Molecular functionE-box binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0140537Molecular functiontranscription regulator activator activity
GO_0001217Molecular functionDNA-binding transcription repressor activity
GO_0042826Molecular functionhistone deacetylase binding
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0002039Molecular functionp53 binding
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0005515Molecular functionprotein binding
GO_0016922Molecular functionnuclear receptor binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0019901Molecular functionprotein kinase binding

IV. Literature review

[source]
Gene nameHIF1A
Protein nameHypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Hypoxia-inducible factor 1-alpha
SynonymshCG_21199
MOP1
PASD8
BHLHE78
DescriptionFUNCTION: Functions as a master transcriptional regulator of the adaptive response to hypoxia . Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia . Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease . Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 . Activity is enhanced by interaction with NCOA1 and/or NCOA2 . Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP . Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia . .; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state . In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons . Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response . .

AccessionsD0VY79
Q16665
ENST00000323441.10 [Q16665-2]
A8MYV6
ENST00000539097.2 [Q16665-3]
ENST00000394997.5
ENST00000337138.9 [Q16665-1]