UCP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070778Biological processL-aspartate transmembrane transport
GO_0071333Biological processcellular response to glucose stimulus
GO_0000266Biological processmitochondrial fission
GO_0032869Biological processcellular response to insulin stimulus
GO_1990542Biological processmitochondrial transmembrane transport
GO_0070542Biological processresponse to fatty acid
GO_0006096Biological processglycolytic process
GO_0015909Biological processlong-chain fatty acid transport
GO_0030225Biological processmacrophage differentiation
GO_0000303Biological processresponse to superoxide
GO_0006541Biological processglutamine metabolic process
GO_1990845Biological processadaptive thermogenesis
GO_0072593Biological processreactive oxygen species metabolic process
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_0071548Biological processresponse to dexamethasone
GO_1902356Biological processoxaloacetate(2-) transmembrane transport
GO_0110099Biological processnegative regulation of calcium import into the mitochondrion
GO_0097421Biological processliver regeneration
GO_1902476Biological processchloride transmembrane transport
GO_0009409Biological processresponse to cold
GO_0001666Biological processresponse to hypoxia
GO_1902358Biological processsulfate transmembrane transport
GO_0034198Biological processcellular response to amino acid starvation
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0015740Biological processC4-dicarboxylate transport
GO_0061179Biological processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0071423Biological processmalate transmembrane transport
GO_1902600Biological processproton transmembrane transport
GO_0071284Biological processcellular response to lead ion
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0019003Molecular functionGDP binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0015078Molecular functionproton transmembrane transporter activity
GO_0015183Molecular functionL-aspartate transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0015131Molecular functionoxaloacetate transmembrane transporter activity
GO_0140787Molecular functionphosphate ion uniporter activity
GO_0008271Molecular functionsecondary active sulfate transmembrane transporter activity
GO_0015108Molecular functionchloride transmembrane transporter activity
GO_0017077Molecular functionoxidative phosphorylation uncoupler activity
GO_0005515Molecular functionprotein binding
GO_0015140Molecular functionmalate transmembrane transporter activity

IV. Literature review

[source]
Gene nameUCP2
Protein nameUncoupling protein 2
Dicarboxylate carrier SLC25A8 (Mitochondrial uncoupling protein 2) (UCP 2) (Solute carrier family 25 member 8) (UCPH)
Dicarboxylate carrier SLC25A8 (Mitochondrial uncoupling protein 2) (Solute carrier family 25 member 8)
SynonymsSLC25A8
DescriptionFUNCTION: Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle, lowering the ATP/ADP ratio and reactive oxygen species (ROS) production . Proton transporter activity is debated, but if it occurs it may mediate inducible proton re-entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. Proton re-entry may be coupled to metabolite transport to allow for proton flux switching and optimal ATP turnover (By similarity). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis (By similarity). Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). Can unidirectionally transport anions including L-malate, L-aspartate, phosphate and chloride ions . Does not mediate adaptive thermogenesis (By similarity). .

AccessionsENST00000663595.2
ENST00000310473.9
ENST00000545212.1
H0YFQ0
P55851
F5GX45
F5H312
ENST00000539764.1
ENST00000536983.5