Insufficient scRNA-seq data for expression of LIF at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 4405.37 | 571 / 578 | 85% | 24.38 | 984 / 1155 |
| intestine | 83% | 1049.54 | 797 / 966 | 96% | 32.46 | 505 / 527 |
| kidney | 93% | 2115.07 | 83 / 89 | 81% | 24.20 | 729 / 901 |
| thymus | 99% | 951.42 | 649 / 653 | 71% | 11.94 | 432 / 605 |
| stomach | 74% | 892.38 | 266 / 359 | 93% | 23.10 | 267 / 286 |
| bladder | 76% | 1358.29 | 16 / 21 | 74% | 19.86 | 375 / 504 |
| skin | 87% | 803.75 | 1570 / 1809 | 59% | 43.00 | 280 / 472 |
| pancreas | 45% | 325.70 | 149 / 328 | 94% | 54.97 | 167 / 178 |
| esophagus | 67% | 504.57 | 971 / 1445 | 70% | 16.88 | 128 / 183 |
| uterus | 67% | 399.25 | 114 / 170 | 51% | 15.01 | 235 / 459 |
| prostate | 87% | 1984.16 | 212 / 245 | 31% | 4.77 | 154 / 502 |
| breast | 70% | 778.86 | 320 / 459 | 43% | 7.12 | 478 / 1118 |
| ovary | 37% | 292.05 | 66 / 180 | 67% | 12.75 | 289 / 430 |
| adrenal gland | 79% | 613.99 | 203 / 258 | 22% | 5.00 | 50 / 230 |
| adipose | 77% | 2810.10 | 928 / 1204 | 0% | 0 | 0 / 0 |
| liver | 34% | 393.90 | 77 / 226 | 29% | 10.15 | 117 / 406 |
| peripheral blood | 52% | 1098.50 | 484 / 929 | 0% | 0 | 0 / 0 |
| heart | 50% | 1434.80 | 427 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 44% | 611.32 | 594 / 1335 | 0% | 0 | 0 / 0 |
| brain | 12% | 89.91 | 328 / 2642 | 27% | 8.11 | 187 / 705 |
| spleen | 38% | 190.31 | 92 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 24% | 2.43 | 11 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 1.74 | 3 / 29 |
| muscle | 6% | 43.92 | 48 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.08 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046888 | Biological process | negative regulation of hormone secretion |
| GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0033141 | Biological process | positive regulation of peptidyl-serine phosphorylation of STAT protein |
| GO_0048286 | Biological process | lung alveolus development |
| GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0045651 | Biological process | positive regulation of macrophage differentiation |
| GO_0097696 | Biological process | cell surface receptor signaling pathway via STAT |
| GO_0046697 | Biological process | decidualization |
| GO_0030225 | Biological process | macrophage differentiation |
| GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0048711 | Biological process | positive regulation of astrocyte differentiation |
| GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0140013 | Biological process | meiotic nuclear division |
| GO_0060426 | Biological process | lung vasculature development |
| GO_0060707 | Biological process | trophoblast giant cell differentiation |
| GO_0060463 | Biological process | lung lobe morphogenesis |
| GO_0006955 | Biological process | immune response |
| GO_0072108 | Biological process | positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| GO_0045835 | Biological process | negative regulation of meiotic nuclear division |
| GO_0072307 | Biological process | regulation of metanephric nephron tubule epithelial cell differentiation |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0045595 | Biological process | regulation of cell differentiation |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0048666 | Biological process | neuron development |
| GO_0048144 | Biological process | fibroblast proliferation |
| GO_0048644 | Biological process | muscle organ morphogenesis |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0010467 | Biological process | gene expression |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0048863 | Biological process | stem cell differentiation |
| GO_0048861 | Biological process | leukemia inhibitory factor signaling pathway |
| GO_0007566 | Biological process | embryo implantation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0035019 | Biological process | somatic stem cell population maintenance |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005829 | Cellular component | cytosol |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0005146 | Molecular function | leukemia inhibitory factor receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | LIF |
| Protein name | Leukemia inhibitory factor (LIF) (Differentiation-stimulating factor) (D factor) (Melanoma-derived LPL inhibitor) (MLPLI) (Emfilermin) |
| Synonyms | HILDA |
| Description | FUNCTION: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. |
| Accessions | ENST00000403987.3 [P15018-2] ENST00000249075.4 [P15018-1] P15018 |
