ITGA2 | OmnibusX

Name	Number of supported studies	Average coverage
basal cell	20 studies	41% ± 15%	Explore
oligodendrocyte	14 studies	40% ± 13%	Explore
endothelial cell	10 studies	23% ± 6%	Explore
epithelial cell	10 studies	35% ± 15%	Explore
ciliated cell	9 studies	24% ± 7%	Explore
secretory cell	7 studies	32% ± 14%	Explore
fibroblast	6 studies	23% ± 3%	Explore
goblet cell	5 studies	22% ± 9%	Explore
type I pneumocyte	5 studies	24% ± 5%	Explore
squamous epithelial cell	4 studies	36% ± 23%	Explore
renal principal cell	4 studies	22% ± 4%	Explore
endothelial cell of vascular tree	3 studies	27% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	33% ± 2%	Explore
transit amplifying cell	3 studies	43% ± 34%	Explore
myoepithelial cell	3 studies	32% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	27% ± 4%	Explore
kidney loop of Henle epithelial cell	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	23% ± 6%	Explore
prostate	4 studies	36% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	98%	2054.60	1409 / 1445	99%	65.42	182 / 183
lung	100%	5218.02	577 / 578	93%	54.91	1072 / 1155
intestine	86%	986.19	835 / 966	96%	40.63	507 / 527
kidney	100%	2821.24	89 / 89	73%	17.19	661 / 901
stomach	71%	908.72	256 / 359	94%	41.38	269 / 286
bladder	76%	1354.90	16 / 21	84%	37.14	424 / 504
thymus	78%	497.22	512 / 653	81%	34.55	489 / 605
breast	76%	1191.20	348 / 459	83%	28.00	932 / 1118
prostate	99%	1966.31	242 / 245	57%	8.37	284 / 502
uterus	75%	536.71	128 / 170	75%	37.54	343 / 459
skin	100%	3311.47	1802 / 1809	47%	9.64	221 / 472
pancreas	33%	213.66	107 / 328	95%	57.53	169 / 178
adrenal gland	100%	3680.54	258 / 258	24%	5.66	55 / 230
spleen	99%	1329.66	239 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	73.83	44 / 45
brain	48%	448.24	1279 / 2642	34%	5.46	241 / 705
blood vessel	64%	426.74	848 / 1335	0%	0	0 / 0
adipose	50%	288.93	602 / 1204	0%	0	0 / 0
ovary	30%	152.44	54 / 180	8%	0.90	36 / 430
liver	6%	59.09	13 / 226	23%	5.52	95 / 406
heart	26%	155.02	227 / 861	0%	0	0 / 0
muscle	1%	3.54	7 / 803	0%	0	0 / 0
peripheral blood	0%	1.65	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030879	Biological process	mammary gland development
GO_0071107	Biological process	response to parathyroid hormone
GO_0031589	Biological process	cell-substrate adhesion
GO_0014075	Biological process	response to amine
GO_0033627	Biological process	cell adhesion mediated by integrin
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0007160	Biological process	cell-matrix adhesion
GO_0009887	Biological process	animal organ morphogenesis
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0038065	Biological process	collagen-activated signaling pathway
GO_0071392	Biological process	cellular response to estradiol stimulus
GO_0030198	Biological process	extracellular matrix organization
GO_0050966	Biological process	detection of mechanical stimulus involved in sensory perception of pain
GO_0007155	Biological process	cell adhesion
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0007596	Biological process	blood coagulation
GO_0048333	Biological process	mesodermal cell differentiation
GO_0051971	Biological process	positive regulation of transmission of nerve impulse
GO_0007565	Biological process	female pregnancy
GO_0031346	Biological process	positive regulation of cell projection organization
GO_0014911	Biological process	positive regulation of smooth muscle cell migration
GO_0014850	Biological process	response to muscle activity
GO_0046718	Biological process	symbiont entry into host cell
GO_0045987	Biological process	positive regulation of smooth muscle contraction
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0032967	Biological process	positive regulation of collagen biosynthetic process
GO_0006929	Biological process	substrate-dependent cell migration
GO_0001666	Biological process	response to hypoxia
GO_0033591	Biological process	response to L-ascorbic acid
GO_0045727	Biological process	positive regulation of translation
GO_0048041	Biological process	focal adhesion assembly
GO_0002687	Biological process	positive regulation of leukocyte migration
GO_0043589	Biological process	skin morphogenesis
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0050927	Biological process	positive regulation of positive chemotaxis
GO_0060100	Biological process	positive regulation of phagocytosis, engulfment
GO_0098609	Biological process	cell-cell adhesion
GO_0006971	Biological process	hypotonic response
GO_0070365	Biological process	hepatocyte differentiation
GO_0010634	Biological process	positive regulation of epithelial cell migration
GO_0045178	Cellular component	basal part of cell
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0034666	Cellular component	integrin alpha2-beta1 complex
GO_0008305	Cellular component	integrin complex
GO_0043679	Cellular component	axon terminus
GO_0005925	Cellular component	focal adhesion
GO_0009986	Cellular component	cell surface
GO_0038064	Molecular function	collagen receptor activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0001540	Molecular function	amyloid-beta binding
GO_0098639	Molecular function	collagen binding involved in cell-matrix adhesion
GO_0001618	Molecular function	virus receptor activity
GO_0005178	Molecular function	integrin binding
GO_0046872	Molecular function	metal ion binding
GO_0043236	Molecular function	laminin binding
GO_0043395	Molecular function	heparan sulfate proteoglycan binding
GO_0005518	Molecular function	collagen binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ITGA2
Protein name	Platelet glycoprotein Ia Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) Integrin subunit alpha 2 Integrin alpha-2 subunit Integrin alpha 2 Alternative protein ITGA2 Integrin alpha-2
Synonyms	CD49B
Description	FUNCTION: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. .; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. .
Accessions	A0A0X8AZ85 F1C627 ENST00000510722.1 F1C628 E7EMF1 D6RG08 Q9NNZ2 Q71V33 ENST00000503810.6 L0R6I3 F1C629 E9PB77 ENST00000509960.5 ENST00000513685.5 G3LGR5 E7ESP4 D6R9H3 ENST00000296585.10 ENST00000509814.5 P17301

ITGA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review