CAV3 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CAV3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
muscle	100%	3260.75	803 / 803	0%	0	0 / 0
heart	98%	895.09	847 / 861	0%	0	0 / 0
blood vessel	49%	94.08	649 / 1335	0%	0	0 / 0
lung	43%	48.27	247 / 578	2%	0.04	20 / 1155
prostate	31%	52.86	76 / 245	8%	0.42	38 / 502
adipose	9%	8.19	112 / 1204	0%	0	0 / 0
breast	7%	7.39	33 / 459	1%	0.06	13 / 1118
tonsil	0%	0	0 / 0	7%	0.39	3 / 45
uterus	2%	1.06	3 / 170	5%	4.30	21 / 459
ovary	4%	2.97	8 / 180	1%	0.03	5 / 430
spleen	3%	3.02	8 / 241	0%	0	0 / 0
esophagus	2%	3.37	30 / 1445	1%	0.03	2 / 183
intestine	2%	1.38	18 / 966	1%	0.02	6 / 527
kidney	2%	1.53	2 / 89	1%	0.02	5 / 901
thymus	2%	3.66	14 / 653	0%	0.02	3 / 605
bladder	0%	0	0 / 21	2%	0.05	12 / 504
brain	0%	0.22	9 / 2642	2%	0.07	12 / 705
stomach	1%	1.03	4 / 359	1%	0.03	2 / 286
skin	1%	1.95	18 / 1809	1%	0.17	3 / 472
peripheral blood	1%	2.70	13 / 929	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0.00	1 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	0%	0	0 / 230
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
pancreas	0%	0	0 / 328	0%	0	0 / 178
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0017015	Biological process	regulation of transforming growth factor beta receptor signaling pathway
GO_0051480	Biological process	regulation of cytosolic calcium ion concentration
GO_0072659	Biological process	protein localization to plasma membrane
GO_0042391	Biological process	regulation of membrane potential
GO_0098909	Biological process	regulation of cardiac muscle cell action potential involved in regulation of contraction
GO_1900826	Biological process	negative regulation of membrane depolarization during cardiac muscle cell action potential
GO_0002027	Biological process	regulation of heart rate
GO_0010831	Biological process	positive regulation of myotube differentiation
GO_2000060	Biological process	positive regulation of ubiquitin-dependent protein catabolic process
GO_0001666	Biological process	response to hypoxia
GO_0035995	Biological process	detection of muscle stretch
GO_0007009	Biological process	plasma membrane organization
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_0045792	Biological process	negative regulation of cell size
GO_0006816	Biological process	calcium ion transport
GO_0071417	Biological process	cellular response to organonitrogen compound
GO_0002931	Biological process	response to ischemia
GO_0006897	Biological process	endocytosis
GO_0031122	Biological process	cytoplasmic microtubule organization
GO_0000165	Biological process	MAPK cascade
GO_0060347	Biological process	heart trabecula formation
GO_0051926	Biological process	negative regulation of calcium ion transport
GO_0038009	Biological process	regulation of signal transduction by receptor internalization
GO_0086005	Biological process	ventricular cardiac muscle cell action potential
GO_0003300	Biological process	cardiac muscle hypertrophy
GO_0060373	Biological process	regulation of ventricular cardiac muscle cell membrane depolarization
GO_1900744	Biological process	regulation of p38MAPK cascade
GO_0051394	Biological process	regulation of nerve growth factor receptor activity
GO_0060299	Biological process	negative regulation of sarcomere organization
GO_0031579	Biological process	membrane raft organization
GO_0008016	Biological process	regulation of heart contraction
GO_1901019	Biological process	regulation of calcium ion transmembrane transporter activity
GO_0051896	Biological process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_2000649	Biological process	regulation of sodium ion transmembrane transporter activity
GO_0060307	Biological process	regulation of ventricular cardiac muscle cell membrane repolarization
GO_0090279	Biological process	regulation of calcium ion import
GO_0006469	Biological process	negative regulation of protein kinase activity
GO_0055013	Biological process	cardiac muscle cell development
GO_0051647	Biological process	nucleus localization
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0033292	Biological process	T-tubule organization
GO_0006641	Biological process	triglyceride metabolic process
GO_0007517	Biological process	muscle organ development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0007520	Biological process	myoblast fusion
GO_0010614	Biological process	negative regulation of cardiac muscle hypertrophy
GO_0001778	Biological process	plasma membrane repair
GO_0060762	Biological process	regulation of branching involved in mammary gland duct morphogenesis
GO_1901380	Biological process	negative regulation of potassium ion transmembrane transport
GO_0051001	Biological process	negative regulation of nitric-oxide synthase activity
GO_0031116	Biological process	positive regulation of microtubule polymerization
GO_0051649	Biological process	establishment of localization in cell
GO_0070836	Biological process	caveola assembly
GO_0061052	Biological process	negative regulation of cell growth involved in cardiac muscle cell development
GO_1900825	Biological process	regulation of membrane depolarization during cardiac muscle cell action potential
GO_0030154	Biological process	cell differentiation
GO_2001288	Biological process	positive regulation of caveolin-mediated endocytosis
GO_0007015	Biological process	actin filament organization
GO_2000009	Biological process	negative regulation of protein localization to cell surface
GO_0043409	Biological process	negative regulation of MAPK cascade
GO_1901017	Biological process	negative regulation of potassium ion transmembrane transporter activity
GO_0014819	Biological process	regulation of skeletal muscle contraction
GO_0008104	Biological process	protein localization
GO_0055117	Biological process	regulation of cardiac muscle contraction
GO_0042593	Biological process	glucose homeostasis
GO_0042632	Biological process	cholesterol homeostasis
GO_0045121	Cellular component	membrane raft
GO_0030018	Cellular component	Z disc
GO_0009986	Cellular component	cell surface
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0014704	Cellular component	intercalated disc
GO_0005886	Cellular component	plasma membrane
GO_0016010	Cellular component	dystrophin-associated glycoprotein complex
GO_0030315	Cellular component	T-tubule
GO_0000139	Cellular component	Golgi membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005901	Cellular component	caveola
GO_0031594	Cellular component	neuromuscular junction
GO_0042383	Cellular component	sarcolemma
GO_0005925	Cellular component	focal adhesion
GO_0031982	Cellular component	vesicle
GO_0071253	Molecular function	connexin binding
GO_0050998	Molecular function	nitric-oxide synthase binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0044325	Molecular function	transmembrane transporter binding
GO_0017080	Molecular function	sodium channel regulator activity
GO_0005515	Molecular function	protein binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0005246	Molecular function	calcium channel regulator activity
GO_0019870	Molecular function	potassium channel inhibitor activity
GO_0043014	Molecular function	alpha-tubulin binding

Gene name	CAV3
Protein name	Caveolin-3 (M-caveolin)
Synonyms
Description	FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae . .
Accessions	P56539 ENST00000343849.3 ENST00000397368.2

CAV3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review