CASP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042542Biological processresponse to hydrogen peroxide
GO_0043029Biological processT cell homeostasis
GO_0030216Biological processkeratinocyte differentiation
GO_0097190Biological processapoptotic signaling pathway
GO_0007605Biological processsensory perception of sound
GO_0032355Biological processresponse to estradiol
GO_0061713Biological processanterior neural tube closure
GO_0043200Biological processresponse to amino acid
GO_0021766Biological processhippocampus development
GO_0034349Biological processglial cell apoptotic process
GO_0045786Biological processnegative regulation of cell cycle
GO_0010165Biological processresponse to X-ray
GO_0009749Biological processresponse to glucose
GO_0007507Biological processheart development
GO_0007611Biological processlearning or memory
GO_0048011Biological processneurotrophin TRK receptor signaling pathway
GO_0006974Biological processDNA damage response
GO_0070269Biological processpyroptotic inflammatory response
GO_0016485Biological processprotein processing
GO_0009411Biological processresponse to UV
GO_0001782Biological processB cell homeostasis
GO_0051146Biological processstriated muscle cell differentiation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0034612Biological processresponse to tumor necrosis factor
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0007413Biological processaxonal fasciculation
GO_0140639Biological processpositive regulation of pyroptotic inflammatory response
GO_0031647Biological processregulation of protein stability
GO_0008627Biological processintrinsic apoptotic signaling pathway in response to osmotic stress
GO_0030218Biological processerythrocyte differentiation
GO_0030182Biological processneuron differentiation
GO_0051402Biological processneuron apoptotic process
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0072734Biological processcellular response to staurosporine
GO_0071887Biological processleukocyte apoptotic process
GO_0051384Biological processresponse to glucocorticoid
GO_0045165Biological processcell fate commitment
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_0001666Biological processresponse to hypoxia
GO_0006508Biological processproteolysis
GO_0035094Biological processresponse to nicotine
GO_0001554Biological processluteolysis
GO_0030163Biological processprotein catabolic process
GO_0001818Biological processnegative regulation of cytokine production
GO_1904019Biological processepithelial cell apoptotic process
GO_0097194Biological processexecution phase of apoptosis
GO_0006915Biological processapoptotic process
GO_0016241Biological processregulation of macroautophagy
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0032025Biological processresponse to cobalt ion
GO_0044346Biological processfibroblast apoptotic process
GO_0009611Biological processresponse to wounding
GO_0030220Biological processplatelet formation
GO_0030889Biological processnegative regulation of B cell proliferation
GO_0051604Biological processprotein maturation
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031264Cellular componentdeath-inducing signaling complex
GO_0005634Cellular componentnucleus
GO_0008047Molecular functionenzyme activator activity
GO_0008233Molecular functionpeptidase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0097153Molecular functioncysteine-type endopeptidase activity involved in apoptotic process
GO_0016005Molecular functionphospholipase A2 activator activity
GO_0002020Molecular functionprotease binding
GO_0097200Molecular functioncysteine-type endopeptidase activity involved in execution phase of apoptosis
GO_0097199Molecular functioncysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0005123Molecular functiondeath receptor binding
GO_0004190Molecular functionaspartic-type endopeptidase activity
GO_0004861Molecular functioncyclin-dependent protein serine/threonine kinase inhibitor activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCASP3
Protein nameCaspase 3
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
SynonymsCPP32
DescriptionFUNCTION: Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis . Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins . At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond . Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) . Cleaves and inactivates interleukin-18 (IL18) . Involved in the cleavage of huntingtin . Triggers cell adhesion in sympathetic neurons through RET cleavage . Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress . Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction . Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) . Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface . .

AccessionsC9JXR7
ENST00000447121.2
P42574
ENST00000393588.8
ENST00000517513.5
ENST00000308394.9
ENST00000523916.5
ENST00000700104.1
A8MVM1
ENST00000700101.1
ENST00000393585.6
A0A8V8TPU5
ENST00000700100.1