TEK report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TEK at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0043434Biological processresponse to peptide hormone
GO_0043627Biological processresponse to estrogen
GO_0007507Biological processheart development
GO_0045766Biological processpositive regulation of angiogenesis
GO_0060347Biological processheart trabecula formation
GO_0043114Biological processregulation of vascular permeability
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0007275Biological processmulticellular organism development
GO_1902533Biological processpositive regulation of intracellular signal transduction
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0001958Biological processendochondral ossification
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0035022Biological processpositive regulation of Rac protein signal transduction
GO_0007267Biological processcell-cell signaling
GO_0002040Biological processsprouting angiogenesis
GO_0016525Biological processnegative regulation of angiogenesis
GO_0033674Biological processpositive regulation of kinase activity
GO_2000351Biological processregulation of endothelial cell apoptotic process
GO_0060216Biological processdefinitive hemopoiesis
GO_0051591Biological processresponse to cAMP
GO_0050728Biological processnegative regulation of inflammatory response
GO_0043066Biological processnegative regulation of apoptotic process
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0048014Biological processTie signaling pathway
GO_0001666Biological processresponse to hypoxia
GO_0001935Biological processendothelial cell proliferation
GO_0051894Biological processpositive regulation of focal adhesion assembly
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0072012Biological processglomerulus vasculature development
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0032878Biological processregulation of establishment or maintenance of cell polarity
GO_0005902Cellular componentmicrovillus
GO_0016324Cellular componentapical plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0034451Cellular componentcentriolar satellite
GO_0045121Cellular componentmembrane raft
GO_0009925Cellular componentbasal plasma membrane
GO_0005884Cellular componentactin filament
GO_0005925Cellular componentfocal adhesion
GO_0005911Cellular componentcell-cell junction
GO_0009986Cellular componentcell surface
GO_0001725Cellular componentstress fiber
GO_0005737Cellular componentcytoplasm
GO_0016323Cellular componentbasolateral plasma membrane
GO_0038023Molecular functionsignaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0019838Molecular functiongrowth factor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTEK
Protein nameTEK receptor tyrosine kinase
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
Mutant TEK tyrosine kinase
Soluble TIE2 variant 1
Soluble TIE2 variant 2 (TEK receptor tyrosine kinase)
SynonymsTIE2
VMCM1
VMCM
DescriptionFUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1. .

AccessionsD9MND2
D9MND0
ENST00000615002.4
ENST00000406359.8 [Q02763-2]
ENST00000380036.10 [Q02763-1]
B5A953
E5RIV9
B5A954
ENST00000519097.5 [Q02763-3]
Q02763
ENST00000519080.1