Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 97% | 1185.28 | 2561 / 2642 | 97% | 2.15 | 687 / 705 |
prostate | 100% | 2147.39 | 245 / 245 | 90% | 1.60 | 452 / 502 |
skin | 100% | 2556.11 | 1809 / 1809 | 88% | 2.36 | 417 / 472 |
esophagus | 100% | 2467.08 | 1445 / 1445 | 86% | 1.62 | 157 / 183 |
lung | 99% | 2010.38 | 575 / 578 | 85% | 1.78 | 980 / 1155 |
intestine | 100% | 2587.51 | 966 / 966 | 79% | 1.54 | 417 / 527 |
bladder | 100% | 2605.81 | 21 / 21 | 78% | 1.56 | 393 / 504 |
breast | 100% | 2320.23 | 459 / 459 | 76% | 1.35 | 851 / 1118 |
uterus | 100% | 2676.56 | 170 / 170 | 75% | 1.49 | 344 / 459 |
stomach | 100% | 1845.24 | 359 / 359 | 73% | 1.40 | 209 / 286 |
thymus | 100% | 2145.84 | 653 / 653 | 67% | 0.95 | 404 / 605 |
kidney | 100% | 2111.53 | 89 / 89 | 65% | 1.04 | 585 / 901 |
pancreas | 100% | 2107.51 | 328 / 328 | 63% | 0.96 | 113 / 178 |
ovary | 100% | 2621.02 | 180 / 180 | 61% | 0.95 | 264 / 430 |
adrenal gland | 100% | 2629.49 | 258 / 258 | 38% | 0.54 | 88 / 230 |
liver | 100% | 1411.36 | 225 / 226 | 39% | 0.62 | 157 / 406 |
adipose | 100% | 2353.90 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 11243.84 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2688.24 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2213.99 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 97% | 2173.69 | 835 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 2.22 | 27 / 29 |
peripheral blood | 93% | 2396.76 | 862 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 68% | 1.26 | 54 / 80 |
tonsil | 0% | 0 | 0 / 0 | 67% | 0.91 | 30 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007584 | Biological process | response to nutrient |
GO_0006164 | Biological process | purine nucleotide biosynthetic process |
GO_0044208 | Biological process | 'de novo' AMP biosynthetic process |
GO_0044209 | Biological process | AMP salvage |
GO_0006189 | Biological process | 'de novo' IMP biosynthetic process |
GO_0006177 | Biological process | GMP biosynthetic process |
GO_0009060 | Biological process | aerobic respiration |
GO_0014850 | Biological process | response to muscle activity |
GO_0001666 | Biological process | response to hypoxia |
GO_0097294 | Biological process | 'de novo' XMP biosynthetic process |
GO_0006167 | Biological process | AMP biosynthetic process |
GO_0042594 | Biological process | response to starvation |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005829 | Cellular component | cytosol |
GO_0004018 | Molecular function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
GO_0070626 | Molecular function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
GO_0042802 | Molecular function | identical protein binding |
Gene name | ADSL |
Protein name | Adenylosuccinate lyase isoform E Adenylosuccinate lyase isoform C Adenylosuccinate lyase (EC 4.3.2.2) (Adenylosuccinase) Adenylosuccinate lyase Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) Adenylosuccinate lyase isoform A |
Synonyms | hCG_40060 AMPS |
Description | FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . FUNCTION: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. . |
Accessions | A0A1B0GTJ7 X5DP48 ENST00000680444.1 X5D8S6 X5D7W4 ENST00000636265.1 ENST00000623063.3 [P30566-1] ENST00000342312.9 [P30566-2] ENST00000679609.1 ENST00000480775.3 ENST00000637669.1 A0A096LP72 V9GY96 A0A096LNY4 A0A7P0Z472 ENST00000624503.1 P30566 A0A096LP92 A0A096LP76 A0A096LNY5 ENST00000623632.4 A0A096LNY6 ENST00000624027.1 A0A384E0N4 ENST00000680978.1 ENST00000623978.3 X5D7V4 ENST00000624474.1 A0A1B0GWF8 ENST00000625194.4 ENST00000216194.11 A0A7P0T8E4 ENST00000636714.1 A0A7P0T9A7 A0A1B0GWJ0 ENST00000637666.2 A0A1B0GTG9 ENST00000679723.1 A0A096LPA2 ENST00000680378.1 B4DEP1 ENST00000423176.6 X5D2Z4 A0A0A6YY92 ENST00000623287.4 ENST00000498234.2 A0A096LNT0 |