CAPN2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	29% ± 9%	Explore
fibroblast	28 studies	26% ± 10%	Explore
natural killer cell	23 studies	28% ± 11%	Explore
smooth muscle cell	23 studies	20% ± 5%	Explore
CD8-positive, alpha-beta T cell	23 studies	25% ± 9%	Explore
pericyte	23 studies	25% ± 8%	Explore
classical monocyte	22 studies	32% ± 13%	Explore
basal cell	20 studies	38% ± 18%	Explore
ciliated cell	19 studies	53% ± 16%	Explore
epithelial cell	19 studies	36% ± 12%	Explore
endothelial cell of lymphatic vessel	18 studies	34% ± 10%	Explore
T cell	17 studies	27% ± 10%	Explore
CD4-positive, alpha-beta T cell	17 studies	24% ± 7%	Explore
conventional dendritic cell	14 studies	35% ± 18%	Explore
non-classical monocyte	14 studies	28% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	32% ± 8%	Explore
capillary endothelial cell	13 studies	30% ± 6%	Explore
regulatory T cell	13 studies	26% ± 8%	Explore
mature NK T cell	12 studies	29% ± 8%	Explore
connective tissue cell	12 studies	21% ± 6%	Explore
astrocyte	12 studies	38% ± 18%	Explore
monocyte	11 studies	23% ± 6%	Explore
type I pneumocyte	11 studies	59% ± 15%	Explore
type II pneumocyte	11 studies	30% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	29% ± 12%	Explore
secretory cell	11 studies	42% ± 10%	Explore
myofibroblast cell	11 studies	23% ± 5%	Explore
endothelial cell of vascular tree	11 studies	23% ± 5%	Explore
dendritic cell	10 studies	35% ± 20%	Explore
club cell	10 studies	43% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	26% ± 9%	Explore
mesothelial cell	9 studies	36% ± 14%	Explore
gamma-delta T cell	9 studies	32% ± 10%	Explore
platelet	8 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	24% ± 9%	Explore
vein endothelial cell	8 studies	23% ± 4%	Explore
mucosal invariant T cell	8 studies	34% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	28% ± 6%	Explore
plasma cell	7 studies	26% ± 13%	Explore
respiratory goblet cell	7 studies	54% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	26% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	24% ± 5%	Explore
kidney loop of Henle epithelial cell	7 studies	32% ± 10%	Explore
mucus secreting cell	7 studies	26% ± 4%	Explore
goblet cell	7 studies	33% ± 22%	Explore
B cell	6 studies	18% ± 2%	Explore
ionocyte	6 studies	57% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	20% ± 3%	Explore
renal alpha-intercalated cell	6 studies	44% ± 13%	Explore
endothelial cell of artery	6 studies	22% ± 4%	Explore
oligodendrocyte precursor cell	6 studies	33% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	29% ± 8%	Explore
plasmablast	5 studies	39% ± 22%	Explore
lymphocyte	5 studies	27% ± 4%	Explore
memory B cell	5 studies	23% ± 5%	Explore
macrophage	5 studies	24% ± 9%	Explore
abnormal cell	5 studies	33% ± 16%	Explore
duct epithelial cell	4 studies	40% ± 6%	Explore
squamous epithelial cell	4 studies	57% ± 15%	Explore
GABAergic neuron	4 studies	34% ± 12%	Explore
exhausted T cell	4 studies	29% ± 11%	Explore
podocyte	4 studies	43% ± 13%	Explore
adventitial cell	4 studies	23% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	28% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	39% ± 6%	Explore
oligodendrocyte	4 studies	22% ± 3%	Explore
glomerular endothelial cell	3 studies	28% ± 4%	Explore
serous secreting cell	3 studies	30% ± 16%	Explore
mononuclear phagocyte	3 studies	23% ± 5%	Explore
luminal cell of prostate epithelium	3 studies	23% ± 7%	Explore
muscle cell	3 studies	36% ± 14%	Explore
glutamatergic neuron	3 studies	36% ± 12%	Explore
pancreatic ductal cell	3 studies	65% ± 22%	Explore
T-helper 1 cell	3 studies	27% ± 10%	Explore
myoepithelial cell	3 studies	22% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	32% ± 16%	Explore
peripheral blood	16 studies	27% ± 9%	Explore
brain	6 studies	28% ± 6%	Explore
uterus	4 studies	23% ± 8%	Explore
kidney	4 studies	23% ± 1%	Explore
breast	4 studies	21% ± 1%	Explore
intestine	4 studies	21% ± 7%	Explore
adipose	3 studies	24% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	22148.95	1445 / 1445	100%	122.29	183 / 183
lung	100%	30202.75	578 / 578	99%	150.15	1149 / 1155
kidney	100%	20459.72	89 / 89	99%	94.77	895 / 901
thymus	100%	17667.04	653 / 653	99%	112.11	598 / 605
intestine	100%	17035.29	966 / 966	98%	94.17	519 / 527
breast	100%	24757.34	459 / 459	98%	121.43	1097 / 1118
uterus	100%	18467.99	170 / 170	98%	126.69	450 / 459
stomach	100%	23814.67	359 / 359	98%	90.61	280 / 286
prostate	100%	14410.87	245 / 245	97%	61.62	488 / 502
ovary	100%	20034.88	180 / 180	97%	74.45	417 / 430
skin	98%	17356.65	1769 / 1809	99%	105.99	466 / 472
brain	96%	7684.84	2545 / 2642	100%	88.00	703 / 705
pancreas	96%	6711.77	315 / 328	99%	160.44	176 / 178
bladder	100%	17946.00	21 / 21	92%	85.52	464 / 504
adrenal gland	100%	23554.05	258 / 258	91%	51.66	210 / 230
liver	30%	1463.86	67 / 226	74%	40.89	301 / 406
adipose	100%	27854.07	1204 / 1204	0%	0	0 / 0
blood vessel	100%	23440.38	1335 / 1335	0%	0	0 / 0
spleen	100%	9780.04	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	25.94	1 / 1
muscle	99%	10172.30	794 / 803	0%	0	0 / 0
heart	99%	8787.40	849 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	123.71	44 / 45
eye	0%	0	0 / 0	90%	48.18	72 / 80
peripheral blood	70%	4670.14	649 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	45%	18.50	13 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042542	Biological process	response to hydrogen peroxide
GO_0051493	Biological process	regulation of cytoskeleton organization
GO_2001247	Biological process	positive regulation of phosphatidylcholine biosynthetic process
GO_0016540	Biological process	protein autoprocessing
GO_0010666	Biological process	positive regulation of cardiac muscle cell apoptotic process
GO_0007565	Biological process	female pregnancy
GO_0035458	Biological process	cellular response to interferon-beta
GO_1901741	Biological process	positive regulation of myoblast fusion
GO_0001666	Biological process	response to hypoxia
GO_0006508	Biological process	proteolysis
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0009612	Biological process	response to mechanical stimulus
GO_0001824	Biological process	blastocyst development
GO_0051603	Biological process	proteolysis involved in protein catabolic process
GO_0007520	Biological process	myoblast fusion
GO_0032675	Biological process	regulation of interleukin-6 production
GO_0048266	Biological process	behavioral response to pain
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0005764	Cellular component	lysosome
GO_0070062	Cellular component	extracellular exosome
GO_0097038	Cellular component	perinuclear endoplasmic reticulum
GO_0005794	Cellular component	Golgi apparatus
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0043025	Cellular component	neuronal cell body
GO_0005925	Cellular component	focal adhesion
GO_0030425	Cellular component	dendrite
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0110158	Cellular component	calpain complex
GO_0005737	Cellular component	cytoplasm
GO_0031143	Cellular component	pseudopodium
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0004198	Molecular function	calcium-dependent cysteine-type endopeptidase activity
GO_0005509	Molecular function	calcium ion binding
GO_0008234	Molecular function	cysteine-type peptidase activity
GO_0008092	Molecular function	cytoskeletal protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CAPN2
Protein name	Calpain 2 Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)
Synonyms	CANPL2
Description	FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' . Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). .
Accessions	C9JWY7 ENST00000434648.5 ENST00000295006.6 [P17655-1] P17655 ENST00000433674.6 [P17655-2]

CAPN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review