HIF3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0006366Biological processtranscription by RNA polymerase II
GO_0001525Biological processangiogenesis
GO_0001666Biological processresponse to hypoxia
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005886Cellular componentplasma membrane
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0046983Molecular functionprotein dimerization activity
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameHIF3A
Protein nameHypoxia inducible factor 3 subunit alpha
Hypoxia-inducible factor 3 alpha subunit
Hypoxia inducible factor 3 subunit alpha (Hypoxia inducible factor 3, alpha subunit, isoform CRA_a)
Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7)
SynonymshCG_21095
PASD7
MOP7
BHLHE17
DescriptionFUNCTION: Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression . Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). .; FUNCTION: [Isoform 2]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression. .; FUNCTION: [Isoform 3]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. .; FUNCTION: [Isoform 4]: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation . May act as a tumor suppressor and inhibits malignant cell transformation . .; FUNCTION: [Isoform 5]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. .

AccessionsO95262
ENST00000300862.7 [Q9Y2N7-2]
H0YE02
Q9Y2N7
H0YDZ5
ENST00000531043.1
ENST00000533789.5
ENST00000600879.5
ENST00000528563.5
E9PJR0
E9PNQ7
ENST00000526506.5
ENST00000600383.1
ENST00000244303.10 [Q9Y2N7-7]
E9PLC8
ENST00000472815.5
ENST00000533145.5
M0R104
ENST00000377670.9 [Q9Y2N7-1]