I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 31% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 31% ± 17% |
Insufficient scRNA-seq data for expression of SRF at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 11180.28 | 1445 / 1445 | 100% | 79.23 | 183 / 183 |
| intestine | 100% | 11377.55 | 966 / 966 | 100% | 62.73 | 527 / 527 |
| ovary | 100% | 5481.94 | 180 / 180 | 100% | 61.28 | 430 / 430 |
| uterus | 100% | 12240.81 | 170 / 170 | 100% | 66.57 | 459 / 459 |
| breast | 100% | 5429.13 | 459 / 459 | 100% | 59.42 | 1115 / 1118 |
| prostate | 100% | 8434.87 | 244 / 245 | 100% | 74.17 | 502 / 502 |
| skin | 100% | 4188.73 | 1805 / 1809 | 100% | 65.43 | 471 / 472 |
| bladder | 100% | 11151.86 | 21 / 21 | 99% | 53.34 | 501 / 504 |
| thymus | 100% | 4725.74 | 650 / 653 | 100% | 53.29 | 604 / 605 |
| lung | 100% | 6012.04 | 576 / 578 | 100% | 59.01 | 1150 / 1155 |
| stomach | 98% | 6517.89 | 353 / 359 | 100% | 67.56 | 286 / 286 |
| kidney | 98% | 3155.91 | 87 / 89 | 97% | 41.33 | 878 / 901 |
| adrenal gland | 99% | 3213.74 | 255 / 258 | 95% | 37.14 | 219 / 230 |
| brain | 88% | 2574.07 | 2338 / 2642 | 100% | 41.19 | 703 / 705 |
| pancreas | 74% | 1653.06 | 244 / 328 | 100% | 52.85 | 178 / 178 |
| liver | 77% | 1940.81 | 174 / 226 | 96% | 27.52 | 389 / 406 |
| blood vessel | 100% | 11884.49 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 45.77 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 73.44 | 29 / 29 |
| muscle | 100% | 5722.02 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4546.62 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 59.73 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 39.67 | 1 / 1 |
| adipose | 100% | 5400.44 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 8026.18 | 848 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 82% | 3203.48 | 762 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0046716 | Biological process | muscle cell cellular homeostasis |
| GO_0001947 | Biological process | heart looping |
| GO_0090009 | Biological process | primitive streak formation |
| GO_0060055 | Biological process | angiogenesis involved in wound healing |
| GO_0022028 | Biological process | tangential migration from the subventricular zone to the olfactory bulb |
| GO_0030878 | Biological process | thyroid gland development |
| GO_0001764 | Biological process | neuron migration |
| GO_0060534 | Biological process | trachea cartilage development |
| GO_0060947 | Biological process | cardiac vascular smooth muscle cell differentiation |
| GO_0030168 | Biological process | platelet activation |
| GO_0060218 | Biological process | hematopoietic stem cell differentiation |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0060261 | Biological process | positive regulation of transcription initiation by RNA polymerase II |
| GO_0001707 | Biological process | mesoderm formation |
| GO_0001666 | Biological process | response to hypoxia |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0046847 | Biological process | filopodium assembly |
| GO_0060532 | Biological process | bronchus cartilage development |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0071333 | Biological process | cellular response to glucose stimulus |
| GO_0060347 | Biological process | heart trabecula formation |
| GO_1902894 | Biological process | negative regulation of miRNA transcription |
| GO_0060292 | Biological process | long-term synaptic depression |
| GO_0009725 | Biological process | response to hormone |
| GO_0051491 | Biological process | positive regulation of filopodium assembly |
| GO_0060425 | Biological process | lung morphogenesis |
| GO_0060324 | Biological process | face development |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0045214 | Biological process | sarcomere organization |
| GO_0045059 | Biological process | positive thymic T cell selection |
| GO_0090136 | Biological process | epithelial cell-cell adhesion |
| GO_0061029 | Biological process | eyelid development in camera-type eye |
| GO_0030220 | Biological process | platelet formation |
| GO_1900222 | Biological process | negative regulation of amyloid-beta clearance |
| GO_0048821 | Biological process | erythrocyte development |
| GO_0021766 | Biological process | hippocampus development |
| GO_0010669 | Biological process | epithelial structure maintenance |
| GO_0002011 | Biological process | morphogenesis of an epithelial sheet |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0061436 | Biological process | establishment of skin barrier |
| GO_0055003 | Biological process | cardiac myofibril assembly |
| GO_0061145 | Biological process | lung smooth muscle development |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0045987 | Biological process | positive regulation of smooth muscle contraction |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0035912 | Biological process | dorsal aorta morphogenesis |
| GO_0048666 | Biological process | neuron development |
| GO_0048538 | Biological process | thymus development |
| GO_0070830 | Biological process | bicellular tight junction assembly |
| GO_0060379 | Biological process | cardiac muscle cell myoblast differentiation |
| GO_0048675 | Biological process | axon extension |
| GO_0043589 | Biological process | skin morphogenesis |
| GO_0009636 | Biological process | response to toxic substance |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0046016 | Biological process | positive regulation of transcription by glucose |
| GO_0045773 | Biological process | positive regulation of axon extension |
| GO_0007507 | Biological process | heart development |
| GO_0034097 | Biological process | response to cytokine |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0007616 | Biological process | long-term memory |
| GO_0001829 | Biological process | trophectodermal cell differentiation |
| GO_0002042 | Biological process | cell migration involved in sprouting angiogenesis |
| GO_0008306 | Biological process | associative learning |
| GO_0035855 | Biological process | megakaryocyte development |
| GO_0043149 | Biological process | stress fiber assembly |
| GO_0090398 | Biological process | cellular senescence |
| GO_0030155 | Biological process | regulation of cell adhesion |
| GO_0051150 | Biological process | regulation of smooth muscle cell differentiation |
| GO_0005634 | Cellular component | nucleus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0031490 | Molecular function | chromatin DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0042826 | Molecular function | histone deacetylase binding |
| GO_0010736 | Molecular function | serum response element binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0070878 | Molecular function | primary miRNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| Gene name | SRF |
| Protein name | Serum response factor (SRF) |
| Synonyms | |
| Description | FUNCTION: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. . |
| Accessions | ENST00000265354.6 P11831 |
