THBS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	35 studies	34% ± 14%	Explore
macrophage	24 studies	27% ± 13%	Explore
classical monocyte	23 studies	47% ± 19%	Explore
pericyte	22 studies	37% ± 15%	Explore
smooth muscle cell	20 studies	39% ± 13%	Explore
monocyte	18 studies	31% ± 15%	Explore
connective tissue cell	12 studies	26% ± 13%	Explore
endothelial cell	11 studies	22% ± 5%	Explore
myofibroblast cell	11 studies	31% ± 8%	Explore
platelet	10 studies	33% ± 14%	Explore
conventional dendritic cell	8 studies	20% ± 6%	Explore
non-classical monocyte	8 studies	36% ± 13%	Explore
alveolar macrophage	7 studies	34% ± 8%	Explore
myeloid cell	7 studies	28% ± 8%	Explore
megakaryocyte	6 studies	62% ± 22%	Explore
intermediate monocyte	6 studies	41% ± 19%	Explore
endothelial cell of vascular tree	6 studies	27% ± 16%	Explore
dendritic cell	5 studies	30% ± 5%	Explore
ionocyte	5 studies	48% ± 11%	Explore
neutrophil	5 studies	37% ± 20%	Explore
epithelial cell	5 studies	24% ± 6%	Explore
adventitial cell	5 studies	36% ± 14%	Explore
basal cell	5 studies	28% ± 15%	Explore
luminal cell of prostate epithelium	4 studies	19% ± 3%	Explore
adipocyte	4 studies	33% ± 24%	Explore
mononuclear phagocyte	3 studies	39% ± 4%	Explore
chondrocyte	3 studies	33% ± 2%	Explore
endothelial cell of artery	3 studies	24% ± 1%	Explore
inflammatory macrophage	3 studies	27% ± 12%	Explore
vein endothelial cell	3 studies	17% ± 0%	Explore
mast cell	3 studies	21% ± 2%	Explore
myoepithelial cell	3 studies	34% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	21% ± 7%	Explore
peripheral blood	3 studies	20% ± 3%	Explore
intestine	3 studies	24% ± 4%	Explore
uterus	3 studies	29% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	95%	35810.34	436 / 459	97%	241.33	1088 / 1118
lung	99%	105023.64	570 / 578	89%	116.59	1030 / 1155
intestine	81%	44366.82	783 / 966	85%	104.88	449 / 527
bladder	76%	32427.95	16 / 21	78%	99.92	394 / 504
esophagus	62%	24152.74	893 / 1445	90%	140.42	165 / 183
stomach	58%	45200.64	210 / 359	92%	127.48	263 / 286
ovary	80%	25889.38	144 / 180	65%	57.58	278 / 430
uterus	86%	41110.06	147 / 170	55%	63.08	251 / 459
prostate	70%	21865.99	172 / 245	70%	66.83	350 / 502
kidney	55%	15084.69	49 / 89	78%	128.10	707 / 901
pancreas	22%	3372.37	71 / 328	92%	210.28	164 / 178
skin	63%	94255.83	1140 / 1809	49%	44.91	231 / 472
adipose	89%	65945.76	1076 / 1204	0%	0	0 / 0
adrenal gland	64%	14485.72	164 / 258	25%	26.84	57 / 230
blood vessel	84%	30598.92	1120 / 1335	0%	0	0 / 0
thymus	49%	10847.13	318 / 653	35%	23.87	209 / 605
spleen	72%	16711.80	173 / 241	0%	0	0 / 0
liver	28%	6493.19	64 / 226	37%	32.21	150 / 406
tonsil	0%	0	0 / 0	60%	37.70	27 / 45
heart	54%	18100.19	463 / 861	0%	0	0 / 0
peripheral blood	28%	8211.34	259 / 929	0%	0	0 / 0
brain	0%	27.03	5 / 2642	11%	10.79	77 / 705
muscle	8%	1246.07	62 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	3.85	2 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0033574	Biological process	response to testosterone
GO_0006986	Biological process	response to unfolded protein
GO_2001027	Biological process	negative regulation of endothelial cell chemotaxis
GO_0006954	Biological process	inflammatory response
GO_0051895	Biological process	negative regulation of focal adhesion assembly
GO_1902043	Biological process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0043537	Biological process	negative regulation of blood vessel endothelial cell migration
GO_0006955	Biological process	immune response
GO_0043066	Biological process	negative regulation of apoptotic process
GO_2000379	Biological process	positive regulation of reactive oxygen species metabolic process
GO_0001666	Biological process	response to hypoxia
GO_0010751	Biological process	negative regulation of nitric oxide mediated signal transduction
GO_0002605	Biological process	negative regulation of dendritic cell antigen processing and presentation
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0009612	Biological process	response to mechanical stimulus
GO_0009410	Biological process	response to xenobiotic stimulus
GO_2000353	Biological process	positive regulation of endothelial cell apoptotic process
GO_0043652	Biological process	engulfment of apoptotic cell
GO_0051592	Biological process	response to calcium ion
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0032914	Biological process	positive regulation of transforming growth factor beta1 production
GO_0018149	Biological process	peptide cross-linking
GO_0010748	Biological process	negative regulation of long-chain fatty acid import across plasma membrane
GO_0032026	Biological process	response to magnesium ion
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0038060	Biological process	nitric oxide-cGMP-mediated signaling
GO_0051918	Biological process	negative regulation of fibrinolysis
GO_0010757	Biological process	negative regulation of plasminogen activation
GO_0010763	Biological process	positive regulation of fibroblast migration
GO_0001953	Biological process	negative regulation of cell-matrix adhesion
GO_0032695	Biological process	negative regulation of interleukin-12 production
GO_0007155	Biological process	cell adhesion
GO_0043032	Biological process	positive regulation of macrophage activation
GO_0001937	Biological process	negative regulation of endothelial cell proliferation
GO_0030194	Biological process	positive regulation of blood coagulation
GO_0045727	Biological process	positive regulation of translation
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0040037	Biological process	negative regulation of fibroblast growth factor receptor signaling pathway
GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0042327	Biological process	positive regulation of phosphorylation
GO_0090051	Biological process	negative regulation of cell migration involved in sprouting angiogenesis
GO_1903588	Biological process	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0043536	Biological process	positive regulation of blood vessel endothelial cell migration
GO_0050921	Biological process	positive regulation of chemotaxis
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0010754	Biological process	negative regulation of cGMP-mediated signaling
GO_0071363	Biological process	cellular response to growth factor stimulus
GO_0002040	Biological process	sprouting angiogenesis
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0048266	Biological process	behavioral response to pain
GO_0016477	Biological process	cell migration
GO_0032570	Biological process	response to progesterone
GO_0030511	Biological process	positive regulation of transforming growth factor beta receptor signaling pathway
GO_0002544	Biological process	chronic inflammatory response
GO_0034605	Biological process	cellular response to heat
GO_0009749	Biological process	response to glucose
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_1903671	Biological process	negative regulation of sprouting angiogenesis
GO_0010759	Biological process	positive regulation of macrophage chemotaxis
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0002581	Biological process	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO_0030335	Biological process	positive regulation of cell migration
GO_2001237	Biological process	negative regulation of extrinsic apoptotic signaling pathway
GO_0006915	Biological process	apoptotic process
GO_0010596	Biological process	negative regulation of endothelial cell migration
GO_0009986	Cellular component	cell surface
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005577	Cellular component	fibrinogen complex
GO_0031091	Cellular component	platelet alpha granule
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0031012	Cellular component	extracellular matrix
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016529	Cellular component	sarcoplasmic reticulum
GO_0030141	Cellular component	secretory granule
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005201	Molecular function	extracellular matrix structural constituent
GO_0005509	Molecular function	calcium ion binding
GO_0070051	Molecular function	fibrinogen binding
GO_0004866	Molecular function	endopeptidase inhibitor activity
GO_0050431	Molecular function	transforming growth factor beta binding
GO_0043236	Molecular function	laminin binding
GO_0043394	Molecular function	proteoglycan binding
GO_0008201	Molecular function	heparin binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0001968	Molecular function	fibronectin binding
GO_0002020	Molecular function	protease binding
GO_0030169	Molecular function	low-density lipoprotein particle binding
GO_0005515	Molecular function	protein binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0005178	Molecular function	integrin binding
GO_0070052	Molecular function	collagen V binding
GO_0017134	Molecular function	fibroblast growth factor binding

IV. Literature review

[source]

Gene name	THBS1
Protein name	Thrombospondin-1 (Glycoprotein G) Thrombospondin 1 THBS1 protein
Synonyms	TSP1 TSP
Description	FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions . Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis . Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis . Ligand for receptor CD47 . Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS . Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36 . Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47 . Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner . Ligand for immunoglobulin-like cell surface receptor SIRPA . Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA . Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging . .
Accessions	P07996 ENST00000260356.6 [P07996-1] ENST00000397591.2 A8MZG1 A0A0B6XK25 A0PJG0

THBS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review