NOL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0062099Biological processnegative regulation of programmed necrotic cell death
GO_0014876Biological processresponse to injury involved in regulation of muscle adaptation
GO_1901222Biological processregulation of non-canonical NF-kappaB signal transduction
GO_0006376Biological processmRNA splice site recognition
GO_0001974Biological processblood vessel remodeling
GO_0002931Biological processresponse to ischemia
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0014736Biological processnegative regulation of muscle atrophy
GO_0051259Biological processprotein complex oligomerization
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0008380Biological processRNA splicing
GO_0043066Biological processnegative regulation of apoptotic process
GO_0001666Biological processresponse to hypoxia
GO_0010659Biological processcardiac muscle cell apoptotic process
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_1902109Biological processnegative regulation of mitochondrial membrane permeability involved in apoptotic process
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0014808Biological processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_1990001Biological processinhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_1903298Biological processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0043027Molecular functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0042802Molecular functionidentical protein binding
GO_0003723Molecular functionRNA binding
GO_0005123Molecular functiondeath receptor binding
GO_0089720Molecular functioncaspase binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0035877Molecular functiondeath effector domain binding

IV. Literature review

[source]
Gene nameNOL3
Protein nameNucleolar protein 3 (Apoptosis repressor with CARD domain) (cDNA, FLJ95803, Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), mRNA)
Nucleolar protein 3
Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30)
SynonymsARC
NOP
hCG_28817
DescriptionFUNCTION: [Isoform 1]: May be involved in RNA splicing. .; FUNCTION: [Isoform 2]: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors . Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis . Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity). .

AccessionsENST00000564992.2 [O60936-2]
O60936
ENST00000568146.1 [O60936-1]
H3BM67
ENST00000564860.1
ENST00000564053.5 [O60936-2]
H3BUN4
ENST00000564992.2
J3QLT7
H3BQJ5
ENST00000563258.1
H3BUP2
ENST00000563439.5
ENST00000565560.5
Q5TZN6
ENST00000566871.5
J3QLS5