ERCC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0000717Biological processnucleotide-excision repair, DNA duplex unwinding
GO_0006281Biological processDNA repair
GO_0048568Biological processembryonic organ development
GO_0009650Biological processUV protection
GO_0006289Biological processnucleotide-excision repair
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0035315Biological processhair cell differentiation
GO_0009411Biological processresponse to UV
GO_0001666Biological processresponse to hypoxia
GO_0006265Biological processDNA topological change
GO_0006915Biological processapoptotic process
GO_0008104Biological processprotein localization
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_1901990Biological processregulation of mitotic cell cycle phase transition
GO_0006979Biological processresponse to oxidative stress
GO_0043065Biological processpositive regulation of apoptotic process
GO_0006283Biological processtranscription-coupled nucleotide-excision repair
GO_0000112Cellular componentnucleotide-excision repair factor 3 complex
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0000439Cellular componenttranscription factor TFIIH core complex
GO_0097550Cellular componenttranscription preinitiation complex
GO_0005675Cellular componenttranscription factor TFIIH holo complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0005524Molecular functionATP binding
GO_0016853Molecular functionisomerase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003684Molecular functiondamaged DNA binding
GO_0043138Molecular function3'-5' DNA helicase activity

IV. Literature review

[source]
Gene nameERCC3
Protein nameGeneral transcription and DNA repair factor IIH helicase subunit XPB (EC 3.6.4.12) (DNA excision repair protein ERCC-3)
ERCC excision repair 3, TFIIH core complex helicase subunit
General transcription and DNA repair factor IIH helicase subunit XPB (TFIIH subunit XPB) (EC 3.6.4.12) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)
DNA helicase (EC 3.6.4.12)
SynonymsXPB
XPBC
DescriptionFUNCTION: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation . When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape . The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. .

AccessionsA0A2R8YFS3
F2Z2V4
ENST00000426778.5
A0A2R8Y4R8
ENST00000456257.1
P19447
ENST00000646654.1
A0A2R8Y6W8
A0A2R8YES7
A0A2R8Y762
ENST00000445889.5
A0A2R8Y681
ENST00000645504.1
H7C309
ENST00000645233.1
A0A2R8Y5L2
ENST00000645736.1
ENST00000644317.1
ENST00000642308.1
ENST00000647169.1
ENST00000285398.7
A0A2R8Y5H0
ENST00000645467.1
ENST00000647496.1