CXCR4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	48 studies	68% ± 20%	Explore
natural killer cell	44 studies	56% ± 20%	Explore
T cell	39 studies	57% ± 23%	Explore
CD8-positive, alpha-beta T cell	36 studies	66% ± 18%	Explore
CD4-positive, alpha-beta T cell	34 studies	61% ± 21%	Explore
macrophage	32 studies	39% ± 16%	Explore
conventional dendritic cell	29 studies	59% ± 19%	Explore
dendritic cell	26 studies	51% ± 20%	Explore
regulatory T cell	25 studies	61% ± 17%	Explore
plasmacytoid dendritic cell	24 studies	70% ± 18%	Explore
classical monocyte	23 studies	35% ± 15%	Explore
mature NK T cell	22 studies	67% ± 21%	Explore
gamma-delta T cell	21 studies	64% ± 17%	Explore
memory B cell	21 studies	72% ± 20%	Explore
naive B cell	20 studies	79% ± 17%	Explore
non-classical monocyte	20 studies	41% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	54% ± 23%	Explore
monocyte	18 studies	42% ± 14%	Explore
mucosal invariant T cell	17 studies	71% ± 20%	Explore
plasma cell	16 studies	43% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	54% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	60% ± 22%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	54% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	64% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	59% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	70% ± 27%	Explore
innate lymphoid cell	10 studies	62% ± 19%	Explore
neutrophil	10 studies	40% ± 16%	Explore
leukocyte	10 studies	53% ± 18%	Explore
myeloid cell	10 studies	45% ± 18%	Explore
plasmablast	9 studies	38% ± 16%	Explore
T follicular helper cell	9 studies	68% ± 18%	Explore
endothelial cell	8 studies	29% ± 15%	Explore
IgG plasma cell	7 studies	29% ± 13%	Explore
precursor B cell	7 studies	74% ± 17%	Explore
immature B cell	7 studies	76% ± 17%	Explore
CD4-positive helper T cell	6 studies	70% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	46% ± 19%	Explore
platelet	6 studies	28% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	56% ± 25%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	55% ± 26%	Explore
mononuclear phagocyte	6 studies	47% ± 28%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	65% ± 26%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	47% ± 26%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	66% ± 20%	Explore
monocyte-derived dendritic cell	5 studies	75% ± 12%	Explore
pro-B cell	5 studies	64% ± 20%	Explore
group 3 innate lymphoid cell	5 studies	81% ± 5%	Explore
double negative thymocyte	5 studies	67% ± 13%	Explore
exhausted T cell	4 studies	55% ± 14%	Explore
hematopoietic precursor cell	4 studies	45% ± 21%	Explore
microglial cell	4 studies	27% ± 7%	Explore
T-helper 17 cell	4 studies	72% ± 16%	Explore
alveolar macrophage	4 studies	33% ± 15%	Explore
germinal center B cell	4 studies	48% ± 14%	Explore
intermediate monocyte	4 studies	51% ± 23%	Explore
erythrocyte	3 studies	51% ± 6%	Explore
abnormal cell	3 studies	52% ± 29%	Explore
thymocyte	3 studies	57% ± 23%	Explore
hematopoietic stem cell	3 studies	48% ± 14%	Explore
lymphocyte	3 studies	43% ± 14%	Explore
epithelial cell	3 studies	30% ± 8%	Explore
follicular B cell	3 studies	80% ± 15%	Explore
mast cell	3 studies	18% ± 1%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	68% ± 5%	Explore
double-positive, alpha-beta thymocyte	3 studies	77% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	50% ± 17%	Explore
lung	10 studies	33% ± 13%	Explore
intestine	6 studies	38% ± 18%	Explore
kidney	6 studies	35% ± 20%	Explore
bone marrow	6 studies	32% ± 24%	Explore
lymph node	6 studies	49% ± 23%	Explore
liver	4 studies	55% ± 23%	Explore
thymus	3 studies	45% ± 19%	Explore
uterus	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	7591.46	577 / 578	94%	127.23	1086 / 1155
breast	81%	2184.96	370 / 459	97%	152.43	1086 / 1118
adrenal gland	99%	7191.68	256 / 258	74%	146.53	170 / 230
thymus	86%	3027.67	563 / 653	78%	143.02	474 / 605
prostate	87%	2272.90	212 / 245	75%	58.50	378 / 502
kidney	67%	2094.15	60 / 89	89%	215.91	802 / 901
stomach	75%	1445.06	269 / 359	72%	75.41	206 / 286
bladder	71%	3160.19	15 / 21	68%	60.91	341 / 504
intestine	66%	5304.92	636 / 966	71%	74.53	376 / 527
uterus	62%	997.45	106 / 170	73%	76.77	335 / 459
ovary	28%	446.64	51 / 180	97%	167.58	416 / 430
pancreas	12%	172.38	40 / 328	94%	168.45	168 / 178
lymph node	0%	0	0 / 0	100%	339.42	29 / 29
spleen	100%	27083.39	241 / 241	0%	0	0 / 0
peripheral blood	98%	37247.85	914 / 929	0%	0	0 / 0
esophagus	35%	537.73	503 / 1445	61%	54.61	112 / 183
liver	46%	705.26	104 / 226	50%	40.50	202 / 406
brain	25%	629.62	663 / 2642	69%	62.00	486 / 705
skin	22%	270.02	390 / 1809	71%	81.48	335 / 472
adipose	90%	2956.66	1080 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	78%	139.66	35 / 45
blood vessel	71%	2131.26	952 / 1335	0%	0	0 / 0
heart	35%	623.49	302 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	23%	11.00	18 / 80
muscle	3%	40.20	27 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002407	Biological process	dendritic cell chemotaxis
GO_0071417	Biological process	cellular response to organonitrogen compound
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0006954	Biological process	inflammatory response
GO_0019722	Biological process	calcium-mediated signaling
GO_0045446	Biological process	endothelial cell differentiation
GO_1905322	Biological process	positive regulation of mesenchymal stem cell migration
GO_0050792	Biological process	regulation of viral process
GO_0051924	Biological process	regulation of calcium ion transport
GO_0050921	Biological process	positive regulation of chemotaxis
GO_0009615	Biological process	response to virus
GO_1990478	Biological process	response to ultrasound
GO_0008038	Biological process	neuron recognition
GO_0043067	Biological process	regulation of programmed cell death
GO_0050966	Biological process	detection of mechanical stimulus involved in sensory perception of pain
GO_1903861	Biological process	positive regulation of dendrite extension
GO_0001764	Biological process	neuron migration
GO_0014823	Biological process	response to activity
GO_0060048	Biological process	cardiac muscle contraction
GO_1904018	Biological process	positive regulation of vasculature development
GO_0043217	Biological process	myelin maintenance
GO_0035470	Biological process	positive regulation of vascular wound healing
GO_0038160	Biological process	CXCL12-activated CXCR4 signaling pathway
GO_0006955	Biological process	immune response
GO_0046718	Biological process	symbiont entry into host cell
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0071345	Biological process	cellular response to cytokine stimulus
GO_0022008	Biological process	neurogenesis
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0030335	Biological process	positive regulation of cell migration
GO_0061154	Biological process	endothelial tube morphogenesis
GO_0050965	Biological process	detection of temperature stimulus involved in sensory perception of pain
GO_0050920	Biological process	regulation of chemotaxis
GO_0001666	Biological process	response to hypoxia
GO_0048714	Biological process	positive regulation of oligodendrocyte differentiation
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0007420	Biological process	brain development
GO_0006915	Biological process	apoptotic process
GO_0030155	Biological process	regulation of cell adhesion
GO_0022029	Biological process	telencephalon cell migration
GO_0060326	Biological process	cell chemotaxis
GO_1901327	Biological process	response to tacrolimus
GO_0002064	Biological process	epithelial cell development
GO_2000448	Biological process	positive regulation of macrophage migration inhibitory factor signaling pathway
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005769	Cellular component	early endosome
GO_0005764	Cellular component	lysosome
GO_0032991	Cellular component	protein-containing complex
GO_0070062	Cellular component	extracellular exosome
GO_0031252	Cellular component	cell leading edge
GO_0009986	Cellular component	cell surface
GO_0070161	Cellular component	anchoring junction
GO_0005770	Cellular component	late endosome
GO_0005737	Cellular component	cytoplasm
GO_0015026	Molecular function	coreceptor activity
GO_0043130	Molecular function	ubiquitin binding
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0016494	Molecular function	C-X-C chemokine receptor activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0001618	Molecular function	virus receptor activity
GO_0036094	Molecular function	small molecule binding
GO_0016493	Molecular function	C-C chemokine receptor activity
GO_0038147	Molecular function	C-X-C motif chemokine 12 receptor activity
GO_0019957	Molecular function	C-C chemokine binding
GO_0032027	Molecular function	myosin light chain binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	CXCR4
Protein name	C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) C-X-C chemokine receptor type 4 Chemokine receptor 4
Synonyms
Description	FUNCTION: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation . Involved in the AKT signaling cascade . Plays a role in regulation of cell migration, e.g. during wound healing . Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels . Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes . Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). .; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus . .
Accessions	ENST00000696152.1 ENST00000696136.1 Q5MIL4 A0A0U3GXA9 A0A0U3FJG0 ENST00000409817.1 [P61073-2] A0A8Q3WLL1 ENST00000696137.1 ENST00000241393.4 [P61073-1] P61073 ENST00000466288.1 A0A8Q3WL10 ENST00000696228.1

CXCR4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review