CLDN3 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	18 studies	54% ± 23%	Explore
ciliated cell	17 studies	61% ± 23%	Explore
goblet cell	9 studies	67% ± 22%	Explore
secretory cell	8 studies	48% ± 18%	Explore
enterocyte	7 studies	74% ± 24%	Explore
progenitor cell	6 studies	81% ± 13%	Explore
type I pneumocyte	5 studies	38% ± 18%	Explore
club cell	5 studies	39% ± 23%	Explore
abnormal cell	5 studies	32% ± 17%	Explore
enteroendocrine cell	5 studies	53% ± 25%	Explore
duct epithelial cell	4 studies	35% ± 19%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	49% ± 17%	Explore
intestinal crypt stem cell	4 studies	81% ± 12%	Explore
transit amplifying cell	4 studies	75% ± 15%	Explore
kidney loop of Henle epithelial cell	4 studies	35% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	40% ± 14%	Explore
deuterosomal cell	3 studies	24% ± 4%	Explore
ionocyte	3 studies	23% ± 3%	Explore
epithelial cell of proximal tubule	3 studies	38% ± 19%	Explore
type II pneumocyte	3 studies	36% ± 12%	Explore
luminal cell of prostate epithelium	3 studies	47% ± 12%	Explore
basal cell	3 studies	40% ± 21%	Explore
progenitor cell of mammary luminal epithelium	3 studies	49% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	8 studies	37% ± 27%	Explore
lung	5 studies	24% ± 6%	Explore
breast	3 studies	21% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	88%	3246.63	216 / 245	98%	763.29	493 / 502
thymus	100%	6794.62	652 / 653	83%	482.64	504 / 605
intestine	54%	8032.72	526 / 966	90%	937.55	472 / 527
kidney	100%	2400.69	89 / 89	33%	193.19	299 / 901
liver	99%	1141.71	224 / 226	26%	63.93	107 / 406
pancreas	100%	2893.08	328 / 328	25%	73.18	45 / 178
breast	59%	1624.27	271 / 459	63%	205.24	703 / 1118
lung	61%	585.90	353 / 578	44%	160.77	508 / 1155
ovary	2%	9.58	4 / 180	99%	1543.52	426 / 430
ureter	0%	0	0 / 0	100%	124.70	1 / 1
stomach	0%	0.94	1 / 359	76%	712.70	216 / 286
bladder	10%	28.52	2 / 21	36%	337.21	179 / 504
skin	44%	289.64	801 / 1809	0%	0	0 / 472
esophagus	3%	16.50	39 / 1445	41%	223.05	75 / 183
uterus	15%	197.94	25 / 170	28%	177.07	127 / 459
brain	13%	54.83	331 / 2642	0%	0	0 / 705
tonsil	0%	0	0 / 0	11%	28.54	5 / 45
adipose	1%	6.08	14 / 1204	0%	0	0 / 0
blood vessel	0%	1.12	3 / 1335	0%	0	0 / 0
peripheral blood	0%	3.08	2 / 929	0%	0	0 / 0
muscle	0%	0.49	1 / 803	0%	0	0 / 0
heart	0%	1.35	1 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	0%	0	0 / 230
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

III. Associated gene sets

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0140459	Biological process	response to Gram-positive bacterium
GO_0010629	Biological process	negative regulation of gene expression
GO_0014045	Biological process	establishment of endothelial blood-brain barrier
GO_0061045	Biological process	negative regulation of wound healing
GO_0022604	Biological process	regulation of cell morphogenesis
GO_1901890	Biological process	positive regulation of cell junction assembly
GO_0010628	Biological process	positive regulation of gene expression
GO_0003382	Biological process	epithelial cell morphogenesis
GO_0007155	Biological process	cell adhesion
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_1903348	Biological process	positive regulation of bicellular tight junction assembly
GO_0045471	Biological process	response to ethanol
GO_0034331	Biological process	cell junction maintenance
GO_0090559	Biological process	regulation of membrane permeability
GO_1905050	Biological process	positive regulation of metallopeptidase activity
GO_0016338	Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO_0030036	Biological process	actin cytoskeleton organization
GO_0030335	Biological process	positive regulation of cell migration
GO_0001666	Biological process	response to hypoxia
GO_0070830	Biological process	bicellular tight junction assembly
GO_0035633	Biological process	maintenance of blood-brain barrier
GO_0030336	Biological process	negative regulation of cell migration
GO_0150111	Biological process	regulation of transepithelial transport
GO_0090303	Biological process	positive regulation of wound healing
GO_0070160	Cellular component	tight junction
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005911	Cellular component	cell-cell junction
GO_0043296	Cellular component	apical junction complex
GO_0016328	Cellular component	lateral plasma membrane
GO_0005923	Cellular component	bicellular tight junction
GO_0016327	Cellular component	apicolateral plasma membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0042802	Molecular function	identical protein binding
GO_0005198	Molecular function	structural molecule activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CLDN3
Protein name	Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1) Claudin
Synonyms	CPETR2 C7orf1 hCG_1737329
Description	FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. . FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .
Accessions	O15551 ENST00000395145.3 Q75L79

CLDN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review