PRKAA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_1904428Biological processnegative regulation of tubulin deacetylation
GO_1905691Biological processlipid droplet disassembly
GO_0061762Biological processCAMKK-AMPK signaling cascade
GO_0010332Biological processresponse to gamma radiation
GO_0060627Biological processregulation of vesicle-mediated transport
GO_0009411Biological processresponse to UV
GO_0014823Biological processresponse to activity
GO_2000758Biological processpositive regulation of peptidyl-lysine acetylation
GO_0031669Biological processcellular response to nutrient levels
GO_0006633Biological processfatty acid biosynthetic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0001666Biological processresponse to hypoxia
GO_0006914Biological processautophagy
GO_0006468Biological processprotein phosphorylation
GO_0031000Biological processresponse to caffeine
GO_0048511Biological processrhythmic process
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0006006Biological processglucose metabolic process
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0071417Biological processcellular response to organonitrogen compound
GO_0071333Biological processcellular response to glucose stimulus
GO_0009631Biological processcold acclimation
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0033135Biological processregulation of peptidyl-serine phosphorylation
GO_0010629Biological processnegative regulation of gene expression
GO_0071361Biological processcellular response to ethanol
GO_0061744Biological processmotor behavior
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0032007Biological processnegative regulation of TOR signaling
GO_0042752Biological processregulation of circadian rhythm
GO_0046318Biological processnegative regulation of glucosylceramide biosynthetic process
GO_0071277Biological processcellular response to calcium ion
GO_0038183Biological processbile acid signaling pathway
GO_0010508Biological processpositive regulation of autophagy
GO_1990044Biological processprotein localization to lipid droplet
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_1903829Biological processpositive regulation of protein localization
GO_0006695Biological processcholesterol biosynthetic process
GO_0045821Biological processpositive regulation of glycolytic process
GO_0045542Biological processpositive regulation of cholesterol biosynthetic process
GO_1903109Biological processpositive regulation of mitochondrial transcription
GO_0071380Biological processcellular response to prostaglandin E stimulus
GO_1904179Biological processpositive regulation of adipose tissue development
GO_0042149Biological processcellular response to glucose starvation
GO_0055089Biological processfatty acid homeostasis
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0008610Biological processlipid biosynthetic process
GO_0048643Biological processpositive regulation of skeletal muscle tissue development
GO_1903944Biological processnegative regulation of hepatocyte apoptotic process
GO_0062028Biological processregulation of stress granule assembly
GO_0015721Biological processbile acid and bile salt transport
GO_0120188Biological processregulation of bile acid secretion
GO_0034599Biological processcellular response to oxidative stress
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0008284Biological processpositive regulation of cell population proliferation
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0016055Biological processWnt signaling pathway
GO_0043627Biological processresponse to estrogen
GO_0019395Biological processfatty acid oxidation
GO_0006338Biological processchromatin remodeling
GO_0070050Biological processneuron cellular homeostasis
GO_0050995Biological processnegative regulation of lipid catabolic process
GO_0042593Biological processglucose homeostasis
GO_0071456Biological processcellular response to hypoxia
GO_0043025Cellular componentneuronal cell body
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0031588Cellular componentnucleotide-activated protein kinase complex
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0000785Cellular componentchromatin
GO_0016324Cellular componentapical plasma membrane
GO_0016607Cellular componentnuclear speck
GO_0005829Cellular componentcytosol
GO_0004672Molecular functionprotein kinase activity
GO_0004691Molecular functioncAMP-dependent protein kinase activity
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0003682Molecular functionchromatin binding
GO_0047322Molecular function[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO_0140823Molecular functionhistone H2BS36 kinase activity
GO_0004679Molecular functionAMP-activated protein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKAA1
Protein name[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase (EC 2.7.11.31) (Acetyl-CoA carboxylase kinase) (Hydroxymethylglutaryl-CoA reductase kinase)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
SynonymshCG_37338
AMPK1
DescriptionFUNCTION: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism . In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation . AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators . Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) . Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A . Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 . Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation . In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes . In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 . In that process also activates WDR45/WIPI4 . Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation . In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin . AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 . Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. .

AccessionsQ13131
Q96E92
ENST00000397128.7 [Q13131-1]
ENST00000296800.4
ENST00000354209.7 [Q13131-2]