ANGPTL4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ANGPTL4 at tissue level.

III. Associated gene sets

GO_0072577Biological processendothelial cell apoptotic process
GO_0070328Biological processtriglyceride homeostasis
GO_0001525Biological processangiogenesis
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0051005Biological processnegative regulation of lipoprotein lipase activity
GO_0043066Biological processnegative regulation of apoptotic process
GO_0006629Biological processlipid metabolic process
GO_0043335Biological processprotein unfolding
GO_0001666Biological processresponse to hypoxia
GO_0045766Biological processpositive regulation of angiogenesis
GO_0005615Cellular componentextracellular space
GO_0072562Cellular componentblood microparticle
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0004857Molecular functionenzyme inhibitor activity
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameANGPTL4
Protein nameAngiopoietin like 4
Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) [Cleaved into: ANGPTL4 N-terminal chain; ANGPTL4 C-terminal chain]
SynonymsPGAR
UNQ171/PRO197
PSEC0166
PP1158
HFARP
ARP4
DescriptionFUNCTION: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism . May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage . Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) . Depending on context, may modulate tumor-related angiogenesis (By similarity). .; FUNCTION: [ANGPTL4 N-terminal chain]: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism . Has higher activity in LPL inactivation than the uncleaved protein . .

AccessionsM0R3A2
ENST00000601886.1
ENST00000601770.1
M0QZ51
ENST00000593998.5 [Q9BY76-1]
M0R369
M0R0N8
Q9BY76
ENST00000595079.5
M0R2X8
ENST00000599192.5
ENST00000301455.7 [Q9BY76-1]
ENST00000594875.1
ENST00000393962.6 [Q9BY76-2]